教員紹介

伊藤 芳久
Ito Yoshihisa

所属・肩書

薬学教育センター長(特任教授)

最終学歴

大阪大学大学院薬学研究科博士前期課程修了

取得学位

医学博士(京都府立医科大学)

所属学会

日本薬理学会、日本神経化学会、日本神経精神薬理学会、日本薬学会、北米神経科学会

現在の専門分野

中枢薬理学、神経薬理学・神経化学・薬学教育、スポーツ医薬

現在の研究課題

●神経変性疾患(認知症、筋萎縮性側索硬化症)のメカニズム解明と新規治療薬候補物質の探索
●高等教育におけるアクティブ・ラーニング手法の活用
●アンチドーピングと薬剤師の職能

主要研究業績

●γ-アミノ酪酸(GABA)受容体の神経化学的・薬理学的研究
●神経変性疾患における小胞体ストレス機構の役割と新規治療薬候補物質の探索
●筋萎縮性側索硬化症における 脊髄Prostaglandin E2の役割の解明と新規治療薬候補物質の探索
●Team-based learning(TBL)による学修効果の検証

最近の研究業績

1.Relevance of endoplasmic reticulum stress response in the hippocampus of chronic kidney disease model mice. Kosuge Y, Osada N, Shimomura A, Miyagishi H, Wada T, Ishige K, Shimba S, Ito Y. Neurosci Lett. 677: 26-31(2018)

2.Pathophysiological role of prostaglandin E2-induced up-regulation of the EP2 receptor in motor neuron-like NSC-34 cells and lumbar motor neurons in ALS model mice. Kosuge Y, Miyagishi H, Yoneoka Y, Yoneda K, Nango H, Ishige K, Ito Y., Neurochem Int. 119: 132-139(2018)

3.Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells. Kosuge Y, Saito H, Haraguchi T, Ichimaru Y, Ohashi S, Miyagishi H, Kobayashi S, Ishige K, Miyairi S, Ito Y., Bioorg Med Chem Lett. 27: 5122-5125(2017)

4.Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34. Nango H, Kosuge Y, Miyagishi H, Sugawa K, Ito Y, Ishige K., J Pharmacol Sci. 135(2): 64-71(2017)

5.Jang S, Yayeh T, Leem YH, Park EM, Ito Y, Oh S., Concanavalin A Induces Cortical Neuron Apoptosis by Causing ROS Accumulation and Tyrosine Kinase Activation., Neurochem Res. 42: 3504-3514(2017)

6.Miyagishi H, Kosuge Y, Takano A, Endo M, Nango H, Yamagata-Murayama S, Hirose D, Kano R, Tanaka Y, Ishige K, Ito Y., Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis. Cell Mol Neurobiol., 37:445-452 (2017)

7.小野真一, 伊藤芳久,石毛久美子,井口法男,小菅康弘 .浅見 覚,泉澤 恵,小林弘子,林 宏行, 鈴木 孝, 岸川幸生,畑 春実,小瀬英司,田畑恵市. Team-based learning(TBL)による学修効果の検証. 薬学雑誌, 131: 1419-142(2017)

8.Kiguchi Y, Aono Y, Watanabe Y, Yamamoto-Nemoto S, Shimizu K, Shimizu T, Kosuge Y, Waddington JL, Ishige K, Ito Y, Saigusa T., In vivo neurochemical evidence that delta1-, delta2- and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats., Eur J Pharmacol., 789: 402-410(2016)

9.Imai T, Kosuge Y, Saito H, Uchiyama T, Wada T, Shimba S, Ishige K, Miyairi S, Makishima M, Ito Y., Neuroprotective effect of S-allyl-L-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition., J Pharmacol Sci., 130:185-188(2016)

10.Kosuge Y, Miyagishi H, Shinomiya T, Nishiyama K, Suzuki S, Osada N, Ishige K, Okubo M, Kawaguchi M, Ito Y., Characterization of Motor Neuron Prostaglandin E2 EP3 Receptor Isoform in a Mouse Model of Amyotrophic Lateral Sclerosis. Biol Pharm Bull., 38; 1964-1968(2015)

11.Ishiuchi K, Kosuge Y, Hamagami H, Ozaki M, Ishige K, Ito Y, Kitanaka S., Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells. J Nat Med., 69:421-426(2015)

12.Imai T, Kosuge Y, Endo-Umeda K, Miyagishi H, Ishige K, Makishima M, Ito Y. Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain. Amino Acids., 46:385-393(2014)

13.Kusama-Eguchi K, Miyano T, Yamamoto M, Suda A, Ito Y, Ishige K, Ishii M, Ogawa Y, Watanabe K, Ikegami F, Kusama T., New insights into the mechanism of neurolathyrism: L-β-ODAP triggers [Ca2+]i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors. Food Chem Toxicol., 67;113-122(2014)

14.Miyagishi H, Kosuge Y, Yoneoka Y, Ozone M, Endo M, Osada N, Ishige K, Kusama-Eguchi K, Ito Y., Prostaglandin E2-Induced Cell Death is Mediated by Activation of EP2 Receptors in Motor Neuron-like NSC-34 Cells. J Pharmacol Sci., 121:347-50(2013)

15.Miyagishi H, Kosuge Y, Ishige K, Ito Y., Expression of microsomal prostaglandin E synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis. J Pharmacol Sci., 118:225-36(2012)

16.Osada, N., Kosuge, Y., Oguchi, S., Miyagishi, H., Ishige, K., Ito, Y. Protective action of mithramycin against neurodegeneration and impairment of synaptic plasticity in the hippocampal CA1 area after transient global ischemia., Neurochem Int., 60: 47-54(2012)

17.Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, Y., Kobayashi, M., Tezuka, M., Kosuge, Y., Ishige, K., Ito, Y., Komiyama, K., Okamatsu-Ogura, Y., Kimura, K., Saito, M. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induce dyslipidemia and ectopic fat formation. PLoS One, 6: e25231(2011)

18.Kasai, A., Kinjo, T., Ishihara, R., Sakai, I., Ishimaru, Y., Yoshioka, Y., Yamamuro, A., Ishige, K., Ito, Y., Maeda, S. Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis. PLoS One, 6: e23968(2011)

19.Kosuge, Y., Taniguchi., Y, Imai, T., Ishige, K., Ito, Y. Neuroprotective effect of mithramycin against endoplasmic reticulum stress-induced neurotoxicity in organotypic hippocampal slice cultures. Neuropharmacology, 61:252-261(2011)

20.Shimada, S., Hirabayashi, M., Ishige, K., Kosuge, Y., Kihara, T., Ito, Y. Activation of dopamine D4 receptors is protective against hypoxia/reoxygenation-induced cell death in HT22 cells. J. Pharmacol. Sci., 114:217-224(2010)

21.Osada, N., Kosuge, Y., Ishige, K., Ito, Y. Characterization of neuronal and astroglial responses to ER stress in the hippocampal CA1 are a in mice following transient forebrain ischemia. Neurochem. Int., 57:1-7(2010)

22.Ibi, D., Nitta, A., Ishige, K., Cen, X., Ohtakara, T., Nabeshima, T., Ito, Y. Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. Neurochem. Int., 56:77-83(2010)

23.Osada, N., Kosuge, Y., Kihara, T., Ishige, K., Ito Y. Apolipoprotein E-deficient mice are more vulnerable to ER stress after transient forebrain ischemia. Neurochem. Int., 54:403-409(2009)

24.Kosuge, Y., Sekikawa-Nishida, K., Negi, H., Ishige, K., Ito, Y. Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice. Neurosci. Lett., 454:165-169(2009)

25.Tokuda, E., Ono, S., Ishige, K., Watanabe, S., Okawa, E., Ito, Y., Suzuki, T. Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis. Exp. Neurol., 213:122-128(2008)

26.Kosuge, Y., Imai, T., Kawaguchi, M., Kihara, T., Ishige, K., Ito, Y. Subregion-specific vulnerability to endoplasmic reticulum stress-induced neurotoxicity in rat hippocampal neurons. Neurochem. Int., 52:1204-121(2008)

27.Cen, X., Nitta, A., Ibi, D., Zhao, Y., Niwa ,M., Taguchi, K., Hamada, M., Ito, Y., Ito, Y., Wang, L., Nabeshima, T. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Mol. Psychiatry., 13: 349; 451-463(2008)

28.Ishimura, A., Ishige, K., Taira, T., Shimba, S., Ono, S., Ariga, H., Tezuka, M., Ito, Y. Comparative study of hydrogen peroxide- and 4-hydroxy-2-nonenal-induced cell death in HT22 cells. Neurochem. Int., 2008; 52:776-85(2008)

29.Oda, T., Kosuge, Y., Arakawa, M., Ishige, K., Ito, Y. Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells. Neurosci. Res., 60:29-39(2008)

30.Nishimura, R., Tabata, K., Arakawa, M., Ito, Y., Kimura, Y., Akihisa, T., Nagai, H., Sakuma, A., Kohno, H., Suzuki, T. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol. Pharm.Bull., 30:1878-1883(2007)

31.Aono, Y., Saigusa, T., Watanabe, S., Iwakami, T., Mizoguchi, N., Ikeda, H., Ishige, K., Tomiyama, K., Oi, Y., Ueda, K., Rausch, WD., Waddington, JL., Ito, Y., Koshikawa, N., Cools, AR. Role of alpha adrenoceptors in the nucleus accumbens in the control of accumbal noradrenaline efflux: a microdialysis study with freely moving rats. J. Neural. Transm., 114:1135-1142(2007)

32.Imai, T., Kosuge, Y., Ishige, K., Ito, Y. Amyloid beta-protein potentiates tunicamycin-induced neuronal death in organotypic hippocampal slice cultures. Neuroscience, 13; 147:639-651(2007)

33.Tokuda, E., Ono, S., Ishige, K., Watanabe, S., Okawa, E., Ito, Y., Suzuki, T. Dysequilibrium between caspases and their inhibitors in a mouse model for amyotrophic lateral sclerosis. Brain Res., 1148:234-242(2007)

34.Ishige, K., Takagi, N., Imai, T., Rausch, WD., Kosuge, Y., Kihara, T., Kusama-Eguchi, K., Ikeda, H., Cools, AR., Waddington, JL., Koshikawa, N., Ito, Y. Role of caspase-12 in amyloid beta-peptide-induced toxicity in organotypic hippocampal slices cultured for long periods. J. Pharmacol. Sci., 104:46-55(2007)

35.Arakawa, M., Ishimura, A., Arai, Y., Kawabe, K., Suzuki, S., Ishige, K., Ito, Y. N-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death. Neurosci. Res., 57:220-229(2007)

36.Tokuda, E., Ono, S., Ishige, K., Naganuma, A., Ito, Y., Suzuki, T. Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis. Toxicology, 229:33-41(2007)

受賞

●第8回日本薬理学会学術奨励賞
●日本大学学部長表彰賞
●文部科学大臣表彰(平成25年度)
●第18回 Journal of Pharmacological Sciences優秀論文賞

著書及び総説

【総説】
1.Osada N, Kosuge Y, Ishige K, Ito Y. Mithramycin, an agent for developing new therapeutic drugs for neurodegenerative diseases. J Pharmacol Sci., 122:251-256(2013)

2.石毛 久美子, 長田 暢弘, 小菅 康弘, 伊藤 芳久, 小胞体ストレスは脳梗塞の治療標的になるか~脳虚血再灌流障害における小胞体ストレスの関与, 日本薬理学雑誌2013:142 9-12(2013)

3.Arakawa, M., Ito, Y. N-acetylcysteine and neurodegenerative diseases: Basic and clinical pharmacology. Cerebellum, 2007; 19:1-7(2007)

4.石毛 久美子,伊藤芳久,片頭痛の治療薬・予防薬の作用メカニズム, 予防的治療薬, 薬局, 58: 27-30(2007)

【著書】
1.伊藤芳久、石毛久美子,わかりやすい薬理学-薬の効くプロセス-(第1版~第12版)創風社(第13版 (2019)を発刊中)

2.伊藤芳久 第2章 精神疾患 薬の解説、第9章 アレルギー疾患 薬の解説、わかりやすい疾患と処方薬の解説 病態・薬物治療編 アークメディア (2018)

3.伊藤芳久他,わかりやすい疾患と処方薬の解説 ケーススタディ編 アークメディア, 編者)(2018)

4.伊藤芳久,第9章 体制神経系に作用する薬・筋の疾患に対する薬,病態,治療,スタンダード薬学シリーズⅡ 6医療薬学 東京化学同人(2015)

5.伊藤芳久, 第2章タンパク質・アミノ酸代謝異常, 第5章 代謝性骨疾患とCa代謝,第8章下垂体後葉,代謝・内分泌疾患と薬物治療への展開,京都廣川書店(2015)

6.伊藤芳久,88章 骨粗鬆症と骨軟化,89章 関節リウマチ,90章 骨関節炎,ファーマコセラピー-病態生理からのアプローチ(百瀬監訳)ブレーン出版(2007)

7.伊藤芳久、石毛久美子,3.中枢神経系に作用する薬物、18.毒性学,薬理学(小池、荻原編),朝倉書店(2007)

8.伊藤芳久他,医学大事典 第19版(共著),南山堂(2006)

9.伊藤芳久,第7章 知覚神経系・運動神経系に作用する薬物,スタンダード薬学シリーズ6 薬と疾病 ⅠA薬の効くプロセス(1),日本薬学会編,東京化学同人(2005)

10.伊藤芳久,第2章 精神疾患,第4章 心臓・血管系疾患,臨床薬物治療学(市田,黒岩監修)アークメディア(2005)

11.伊藤芳久,実践医療薬理学演習(ケース・スタディー編) ,PROUS SCIENCE,(共著)(1999)

12.伊藤芳久,福田英臣,第11章GABA受容体・ベンゾジアセピン受容体,細胞膜の受容体 基礎知識から最新の情報まで(高柳編),南山堂(1998)

13.Ito, Y.; Ishige, K.; Aizawa, M.; Fukuda, H.,Studies on the genesis and regulation of absence seizures in genetic and drug-induced models. In Order & Non-Order(Ito,Y.,
Kawakami, I.,Konnno, K., Matunaga, Y., Shimada, I. and Tsubokawa,T. Eds) pp126-133, World Scientific, England(1998)

14.伊藤芳久,Ⅱ-1精神・神経疾患,病態生理・生化学-医療薬学へのアプローチ-(植木編),廣川書店(1996)

15.Ito, Y., Ishige, K; Fukuda, H. Role of GABAB receptors in thalamic and hippocampal functions In: Brain Process and Memory (Ishikawa, K, McGaugh, J.L. and Sakata H. Eds.)pp117-126, Elsevior, The Netherlands(1996)

16.Ito, Y., Ishige, K., Aizawa, M., Fukuda, H. GABAB antagonists block -butyrolactone-induced absence seizures and coordinated induction of transcription factors in mouse brain. In: GABA: Receptors, Transporters and Metabolism.(C. Tanaka and N.G. Bowery Eds.) pp. 313-320, Birkhauser Verlag, Switzerland(1996)

17.Ito,Y., Ishige, K., Aizawa, M., Fukuda, H. Pharmacological studies on generalized absence seizure regulation in genetic- and drug-induced model. In GABA: Receptors,
Transporters and Metabolism.(C. Tanaka and N.G. Bowery Eds .)pp. 321-324, Birkhauser Verlag, Switzerland(1996)

18.伊藤芳久,第10章GABA-ベンゾジアゼピン受容体,薬物受容体の基礎(高柳編)薬業時報社 (1994)

19.福田英臣,伊藤芳久,第3章神経薬理学における電気生理学的手法,神経伝達物質(瀬川、福田,栗山監訳) 薬物作用と疾患,廣川書店(1991)

20.伊藤芳久,第12章GABA受容体,神経伝達物質 薬物作用と疾患(瀬川、福田,栗山監訳,廣川書店(1991)

21.Ito, Y., Makimura, M., Murakoshi, Y., Kappa-agonist-like properties of 3H-naloxone binding in guinea pig brain. In: New Leads in Opioid Research. (J.M. Ree, A.H. Mulder, V.M.Wiegant and T.B.W. Greidanus Eds.) pp. 204-206, Excerpta Medica, North Holland(1990)

22.Kuriyama, K., Ito, Y., Some characteristics of solubilized and partially purified cerebral GABA and benzodiazepine receptor. In: CNS Receptors from Molecular Biology to Behavior. (P. Mandel and F.V. DeFeudis Eds.) pp. 59-70, Raven Press, New York(1983)

23.Ito,Y., Kuriyama, K., Ueno, E., Nishimura C., Yoneda, Y., Solubilization and partial purification of cerebral GABA receptor,In: Problems in GABA Research. From brain to bacteria. (E. Roberts and Y. Okada Eds.) pp. 316-327, Excerpta Medica, North Holland(1983)

24.益川徹,笠松貞夫,伊藤芳久,井上和美,岡本博,岩田平太郎,赤血球におけるセレンの役割,栄養学と中毒学-その方法論的接点,p171-182(鈴木、井村、鈴木編)篠原出版(1983)

入試情報 ADMISSION