教員紹介

奥平 和穂
Okudaira Kazuho

所属・肩書

薬学教育センター(教授)

最終学歴

東京大学薬学系大学院博士課程

取得学位

博士(薬学)

現在の専門分野

薬学教育、薬物動態学

現在の研究課題

学習の効率化

主要研究業績

●薬物相互作用の定量的予測法の確立
●薬物毒性の速度論的解析法の構築

最近の研究業績

1.Involvement of reactive oxygen species in sonodynamically induced apoptosis using a novel porphyrin derivative.
Yumita N, Iwase Y, Nishi K, Komatsu H, Takeda K, Onodera K, Fukai T, Ikeda T, Umemura S, Okudaira K, Momose Y.
Theranostics. 2012, 2: 880-8.

2.Involvement of reactive oxygen species in sonodynamically induced apoptosis by 4-formyloximeetylidene-3-hydroxy-2-vinyl-deuterio- porphynyl  (IX)-6-7- diaspartic acid (ATX-S10). Yumita N, Iwase Y, Nishi K, Ikeda T, Fukai T, Onodera K, Takeda K, Umemura S, Komatsu H, Nishi H, Okudaira K, Momose Y.
Biochem. Anal. Biochem., 2012, S2, 2-7.

3.Sonodynamically-induced antitumor effect of mono-l-aspartyl chlorin e6 (NPe6). Yumita N, Iwase Y, Nishi K, Ikeda T, Komatsu H, Fukai T, Onodera K, Nishi H, Takeda K, Umemura S, Okudaira K, Momose Y.
Anticancer Res., 2011, 31: 501-506.

4.Sonodynamic antitumor effect of zinc phthalocyanine tetrasulfate on murinne solid tumor colon 26.
Yumita N, Iwase Y, Onodera K, Nishi H,Takeda K, Fukai T, Umemura S, Okudaira K, Momose Y.
Pharmacometrics, 2011; 80: 13-20

5.Species difference of metabolic clearance of bisphenol A using cryopreserved hepatocytes from rats, monkeys and humans.
Kurebayashi H, Okudaira K, Ohno Y.
Toxicol. Lett., 2010, 198: 210-215.

6.Contribution of Rat Pulmonary Metabolism to the Elimination of Lidocaine, Midazolam, and Nifedipine.
Aoki M, Okudaira K, Haga M, Nishigaki R, Hayashi M.
Drug Metab. Dispos., 2010, 38: 1183-1188.

7.Sonodynamically-induced apoptosis and active oxygen generation by gallium-porphyrin complex, ATX-70.
Yumita N, Okudaira K, Momose Y, Umemura
Cancer Chemother Pharmacol., 2010, 66: 1071-1078.

8.Prediction of the metabolic interaction of nateglinide with other drugs based on in vitro studies.
Takanohashi T, Koizumi T, Mihara R, Okudaira K.
Drug Metab. Pharmacokinet., 2007, 22: 409-418.

9.A facile access to spiro furanone skeleton based on Pd (II)-mediated cyclization-carbonylation of propargylic ester
Kato K, Nouchi H, Ishikura s, Takaishi S, Motodate S, Tanaka H, Okudaira K, Mochida T, Nishigaki R, Shigenobu K, Akita H.
Tetrahedron, 2006, 62: 2545-2554

10.Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.
Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y.
Drug Metab. Dispos., 2005, 33: 1477-1481.

11.The effects of emulsifying agents on disposition of lipid-soluble drugs included in fat emulsion.
Suzuki Y, Masumitsu Y, Okudaira K, Hayashi M
Drug Metabol. Pharmacokin., 2004, 19: 62-67

12.ATP-dependent transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) and its xenobiotic taurine conjugate (Z-335-Tau) by rat bile canalicular membrane vesicles.
Kawabata Y, Kamada E, Furuta S, Takei M, Kurimoto T, Okudaira K, Nishigaki R
Pharm. Res., 2004, 21: 467-475

13.Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.
Azuma R, Komuro M, Kawaguchi Y, Okudaira K, Hayashi M, Kiwada H
Drug Metabol. Pharmacokin., 2002,

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