教員紹介

酒井(牛久保) 裕子
Sakai(Ushikubo) Hiroko

所属・肩書

薬学教育センター(講師)

最終学歴

武蔵野大学大学院

取得学位

博士(薬科学)

所属学会

日本薬理学会、日本薬学会

現在の専門分野

眼薬理学、神経薬理学

現在の研究課題

●抗白内障薬の検索
●水晶体透明性維持機構の解明
●PC12 cell を用いたデキサメタゾンとうつ病の関連性について

主要研究業績

●視神経節細胞脱落ラットを用いた網膜血管の構築過程と機能の解析
●網膜血管伸長報告調節プログラムの解明による新規糖尿病網膜症治療戦略の開拓
●認知症治療に有用な高活性フィセチン誘導体の創製

最近の研究業績

1.Nakano A, Asano D, Kondo R, Mori A, Arima S, Ushikubo H, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T. Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity. Exp Eye Res 168: 115-127 (2018)

2.Sakamoto K, Okuwaki T, Ushikubo H, Mori A, Nakahara T, Ishii K. Activation inhibitors of nuclear factor kappa B protect neurons against the NMDA-induced damage in the rat retina. J Pharmacol Sci. 135 72-80 (2017)

3.Morita A, Ushikubo H, Mori A, Arima S, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T. A delay in vascularization induces abnormal astrocyte proliferation and migration in the mouse retina. Dev Dyn 246: 186-200 (2017)

4.Morita A, Ushikubo H, Mori A, Sakamoto K, Nakahara T. Exposure to high-concentration oxygen in the neonatal period induces abnormal retainal vasculr patterning in mice. Birth Defects Res B Dev Reprod Toxicol 107: 216-224 (2016)

5.Sakamoto K, Murakami Y, Sawada S, Ushikubo H, Mori A, Nakahara T, Ishii K. Apelin-36 is protective against N-methyl-D-aspartic-acid-induced retinal ganglion cell death in the mice. Eur J Pharmacol. 791: 213-220 (2016)

6.Hayashi I, Aoki Y, Ushikubo H, Asano D, Mori A, Sakamoto K, Nakahara T, Ishii K. Protective effects of PF-4708671 against N-methyl-d-aspartic acid-induced retinal damage in rats. Fundam Clin Pharmacol. 30: 529-536 (2016)

7.Hayashi I, Aoki Y, Asano D, Ushikubo H, Mori A, Sakamoto K, Nakahara T, Ishii K.Protective Effects of Everolimus against N-Methyl-D-aspartic Acid-Induced Retinal Damage in Rats. Biol Pharm Bull. 38:1765-1771 (2015)

8.Nakano A, Nakahara T, Mori A, Ushikubo H, Sakamoto K, Ishii K. Short-term treatment with VEGF receptor inhibitors induces retinopathy of prematurity-like abnormal vascular growth in neonatal rats. Exp Eye Res. 143: 120-131 (2016)

9.Iizuka N, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K. Retinal region-dependent susceptibility of capillaries to high-concentration oxygen exposure and vascular endothelial growth factor receptor inhibition in neonatal mice. J Pharmacol Sci. 129: 107-118 (2015)

10.Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos. 43: 1071-1076 (2015)

11.Aoki Y, Nakahara T, Asano D, Ushikubo H, Mori A, Sakamoto K, Ishii K. Preventive effects of rapamycin on inflammation and capillary degeneration in a rat model of NMDA-induced retinal injury. Biol Pharm Bull. 38: 321-324 (2015)

12.Morita A, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K. Treatment of newborn mice with inhibitors of vascular endothelial growth factor receptor tyrosine kinase induces abnormal retinal vascular patterning. Biol Pharm Bull. 37: 1986-1989 (2014)

13.Yagasaki R, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K. Anti-angiogenic effects of mammalian target of rapamycin inhibitors in a mouse model of oxygen-induced retinopathy. Biol Pharm Bull. 37: 1838-1842 (2014)

14.Ushikubo H, Tanimoto Y, Abe K, Asakawa T, Kan T, Akaishi T. 3,3',4',5'-Tetrahydroxyflavone induces formation of large aggregates of amyloid β protein. Biol Pharm Bull. 37: 748-754 (2014)

15.Ushikubo H, Watanabe S, Tanimoto Y, Abe K, Hiza A, Ogawa T, Asakawa T, Kan T, Akaishi T. 3,3',4',5,5'-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation. Neurosci Lett. 513: 51-56 (2012)

入試情報 ADMISSION