教員紹介

中島 敏治
Nakajima Toshiharu

所属・肩書

健康薬学科/生体防御学研究室(教授)

最終学歴

北里大学大学院 衛生学研究科修士課程

取得学位

薬学博士(城西大学)

所属学会

日本免疫学会、日本アレルギー学会、日本薬学会

現在の専門分野

免疫学、アレルギー学

現在の研究課題

アレルギー性炎症調節機構に関する研究

主要研究業績

●低親和性IgEレセプター(CD23)分子に関する研究
●エオタキシン産生調節およびアレルギー性疾患における関与の検討
●マイクロアレーを用いたマスト細胞の網羅的遺伝子発現解析
●マイクロアレーによるヒト白血球の網羅的遺伝子発現解析
●ケモカインCCL20産生T細胞に関する研究

最近の研究業績

1.Semimature stage: a checkpoint in a dendritic cell maturation program that allows for functional reversion after signal-regulatory protein-alpha ligation and maturation signals. D. Braun, L. Galibert, T. Nakajima, H. Saito, VV. Quang, M. Rubio, M. Sarfati. J. Immunol. 177(12), 8550-8559. (2006)

2.A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression. A. Kotani, IM. Okazaki, M. Muramatsu, K. Kinoshita, NA. Beum, T. Nakajima, H. Saito, T. Honjo, Proc. Natl. Acad. Sci. U. S. A. 102(12), 4506-4511 (2005)

3.Gene expression profiling of the effect of high-dose intravenous Ig in patients with kawasaki disease. J. Abe, T. Jibiki, S. Noma, T. Nakajima, H. Saito, M. Terai, J. Immunol. 174(9), 5837-5845 (2005)

4.Identification of granulocyte subtype-selective receptors and ion channels by using a high-density oligonucleotide probe array. T. Nakajima, M. Iikura, Y. Okayama, K. Matsumoto, C. Uchiyama, T. Shirakawa, X. Yang, CN. Adra, K. Hirai, H. Saito, J. Allergy Clin. Immunol. 133(3), 528-535 (2004)

5.TNF-α and IL-4 regulate expression of fractalkine (CX3CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts. M. Yoshikawa, T. Nakajima, K. Matsumoto, N. Okada, M. Iida, N. Otori, S. Haruna, H. Moriyama, T. Imai, H. Saito, FEBS Lett. 561, 105-110 (2004)

6.Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro. K. Matsumoto, M. Terakawa, K. Miura, S. Fukuda, T. Nakajima, H. Saito, J. Immunol. 172(4), 2186-2193 (2004)

7.TNF-α and IL-4 regulate expression of IL-13 receptor α2 on human fibroblast. M. Yoshikawa, T. Nakajima, K. Matsumoto, M. Iida, N. Otori, S. Haruna, H. Moriyama, H. Saito, Biochem. Biophys. Res. Com. 312(4), 1248-1255 (2003)

8.Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation. V. Doyen, M. Rubio, D. Braun, T. Nakajima, J. Abe, H. Saito, G. Delespesse, M. Sarfati, J. Exp. Med. 198(8), 1277-1283 (2003)

9.Identification of specific gene expression profile in human mast cells via Toll-like receptor 4 and FcεRI. S. Okumura, J. Kashiwakura, H. Tomita, K. Matsumoto, T. Nakajima, H. Saito and Y. Okayama, Blood 102, 2547-2554 (2003)

10.Pepsin-resistant 16-kD buckwheat protein is associated with immediate hypersensitivity reaction in patients with buckwheat allergy. K. Tanaka, K. Matsumoto, A. Akazawa, T. Nakajima, T. Nagasu, Y. Iikura, H. Saito, Int. Arch. Allergy Immunol. 129(1), 49-56 (2002)

11.Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcε receptor I cross-linking. T. Nakajima, N. Inagaki, A. Tanaka, H. Tanaka, M. Yoshikawa, M. Tamari, K. Hasegawa, K. Matsumoto, H. Tachimoto, M. Ebisawa, G. Tsujimoto, H. Matsuda, H. Nagai, H. Saito, Blood. 100(12), 3861-3868 (2002)

12.Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: abundant expression of major basic protein in mast cells. T. Nakajima, K. Matsumoto, H. Suto, K. Tanaka, M. Ebisawa, H. Tomita, K. Yuki, T. Katsunuma, A. Akasawa, R. Hashida, Y Sugita, H. Ogawa, C. Ra, H. Saito, Blood. 98(4), 1127-1134 (2001)

13.Selective down-regulation of high-affinity IgE receptor (FcεRI) 亜α-chain messenger RNA among transcriptome in cord blood-derived versus adult peripheral blood-derived cultured human mast cells. M. Iida, K. Matsumoto, H. Tomita, T. Nakajima, A. Akasawa, NY. Ohtani, NL. Yoshida, K. Matsui, A. Nakada, Y. Sugita, Y. Shimizu, S. Wakahara, T. Nakao, Y. Fujii, C. Ra, H. Saito, Blood. 97(4), 1016-1022 (2001)

14.IL-4 induces eotaxin production in corneal keratocytes but not in epithelial cells. K. Fukagawa, T. Nakajima, H. Saito, K. Tsubota, S. Shimmura, M. Natori, K. Hirai, Int. Arch. Allergy Immunol. 121(2), 144-150 (2000)

15.Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells. T. Sekiya, M. Miyamasu, M. Imanishi, H. Yamada, T. Nakajima, M. Yamaguchi, T. Fujisawa, R. Pawankar, Y. Sano, K. Ohta, A. Ishii, Y. Morita, K. Yamamoto, K. Matsushima, O. Yoshie, K. Hirai, J. Immunol. 165(4), 2205-2213 (2000)

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