教員紹介

北川 康行
Kitagawa Yasuyuki

所属・肩書

健康薬学科/薬物解析学研究室 (教授)

最終学歴

大阪大学大学院 理学研究科 博士課程修了(高分子学専攻)

取得学位

理学博士(大阪大学)

所属学会

日本薬学会、日本結晶学会、日本生化学会、日本化学会

現在の専門分野

構造生物学

現在の研究課題

●NADの立体配座に着目したNAD依存酵素阻害剤の開発研究
●計算科学的手法を用いた薬物と蛋白質の相互作用解析
●生体関連分子のX線結晶構造解析

主要研究業績

●蛇毒由来のセリンプロテアーゼの構造研究
●Fe-SODの構造解析
●リボ核酸分解酵素の構造解析
●FGFの構造解析
●Cu,Zn-SODの構造解析
●X線を用いた銅と亜鉛の識別
●アクロモバクタープロテアーゼの構造解析

最近の研究業績

1.Efficient synthesis of a water-soluble glucoamide inhibitor against human aldose reductase by click chemistry.
Mikio Fujii, Shinji Sudo, Yasuyuki Kitagawa and Keisuke Kato
(2013) J. Carbohydr. Chem. 32, 424-437

2.Primary structure and characterization of a non hemorrhagic metalloproteinase with fibrinolytic activity, from the snake venom of Protobothrops tokarensis (Tokara-habu)
Etsuko Oyama, Yasuyuki Kitagawa and Hidenobu Takahashi
(2013) Toxicon, 70, 153–161

3.Tuning efficiency of the 4-exo-trig cyclization by the electronic effect : ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside
Hiroki Kumamoto, Sachiko Kawahigashi, Hiromi Wakabayashi, Tomohiko Nakano, Tomoko Miyaike, Yasuyuki Kitagawa, Hiroshi Abe, Mika Ito, Kazuhiro Haraguchi, Jan Balzarini, Masanori Baba and Hiromichi Tanaka
(2012) Chem. Commun., 48, 10993-10995

4.Crystal structure of the inhibitor-free form of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum.
Tomonobu UMEDA, Nobutada TANAKA, Yoshio KUSAKABE, Yuki ODANAKA, Satoko MATSUBAYASHI, Yasuyuki KITAGAWA, and Kazuo T. NAKAMURA
(2011) Photon Factory Activity Report 2010, 28, 250

5.Electrophilic glycosidation employing 3,5-O-(di-tert-butylsilylene)-
erythro-furanoid glycal leads to exclusive formation of the β-anomer: synthesis of 2’-deoxynucleosides and its 1’-branched analogues
Kazuhiro Haraguchi, Kiju Konno, Kaori Yamada, Yasuyuki Kitagawa, Kazuo T. Nakamura, Hiromichi Tanaka
(2010) Tetrahedron, 66, 4587-4600

6.Synthesis of (±)-4’-ethynyl-5’,5’-difluoro-2’,3’-dehydro-3’-
deoxy-carnocyclic thymidine: a difluoromethylidene analogue of promising anti-HIV agent Ed4T
Hiroki Kumamoto, Kazuhiro Haraguchi, Mayumi Ida, Kazuo T. Nakamura, Yasuyuki Kitagawa, Takayuki Hamasaki, Masanori Baba, Satoko Shimbara Matsubayashi, Hiromichi Tanaka
(2009) Tetrahedron, 65, 7630-7636

7.Crystal structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum complexed with a selective inhibitor.
Nobutada TANAKA, Yoshio KUSAKABE, Ken-ichi AOKI, Yasumitsu SAKAMOTO,
Masaru TSUNODA, Yasuyuki KITAGAWA, and Kazuo T. NAKAMURA
(2007) Photon Factory Activity Report 2006, 24, 216

8.Crystal Structure of Iron Superoxide Dismutase from Obligate Anaerobic Bacterium Yasuyuki Kitagawa, Ikuko Sekiya, Masaya Kitamura, Takeshi Nakanishi, Kazuo T. Nakamura
(2005) Acta Crystallogr., A61, c209

9.Crystal structure of 1,10-dibromodecane and its infrared intensity in a urea clathrate and in the crystal
Isao Kanesaka, Sachie Matsuzawa, Tsutomu Ishioka, Yasuyuki Kitagawa, Keiichi Ohno
(2004) Spectrochim. Acta, A60, 2621-2626

10.Crystal structure analysis of the ternary complex of tyrosyl-tRNA synthetase
Nobutada Tanaka, Yoshio Kusakabe, Noriko Naba, Hiroshi Uemura,
Yasumitsu Sakamoto, Masaru Tsunoda, Yasuyuki Kitagawa, and Kazuo T. Nakamura
(2003) SPring-8 User Experiment Report, 2003A0735-RL1-np28

11.Crystal structure of 4-chloro-2-methyl phenol and its infrared study on phase transition
Isao Kanesaka, Yoshio Fujii, Tsutomu Ishioka, and Yasuyuki Kitagawa
(2000) Asian Journal of Spectroscopy 4, 11-19

12.Crystal Structure of N,N'-Distearyl-1,4-diazabicyclo[2.2.2]octane Dibromide
Tsutomu Ishioka, Noriko Matsuda, Yasuyuki Kitagawa, and Kazuo T. Nakamura
(2000) Bull. Chem. Soc. Jpn. , 73, 2725-2726

著書及び総説

1.「構造式手帳Minimum Requirement」(分担共著) 京都廣川書店(2013年1月)
2.「わかりやすい物理化学第2版」(分担著書)北川康行 廣川書店(2010年9月)
3.「わかりやすい物理化学」(分担著書)北川康行 廣川書店(2005年3月)

入試情報 ADMISSION