教員紹介

黒岩 美枝
Kuroiwa Mie

所属・肩書

臨床薬学科/機能形態学研究室(教授)

最終学歴

昭和大学薬学部生物薬学科

取得学位

博士(歯学)

所属学会

日本解剖学会、日本医療薬学会、神奈川県薬剤師会、藤沢市薬剤師会

現在の専門分野

機能形態学、臨床薬学、免疫組織学

現在の研究課題

●薬剤師のための学術スキルアップ
●アミロイドーシス形成の解明

主要研究業績

Immunohistological study of experimental mourn AA amyloidosis. Kuroiwa M, Aoki K., Izumiyama N. : In Protein Reviews vol. 4. Protein Misfolding, Aggregation, and Conformation Diseases. Part A: Protein aggregation and conformational diseases. Visualization of protein deposits in vivo. : Ed: Uversky V.N. and Fink A. L.:New York, Springer. (2006) 4: 277-283.

最近の研究業績

1.Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis. Ikeda H, Aida J, Hatamochi A, Hamasaki Y, Izumiyama NS, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Tomita K, Hiraishi N, Kuroiwa M, Matsuura M, Sanada Y, Kawano Y, Arai T, Takubo K. Hum Pathol. (2014) 45: 473-480.

2.hort telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms. Izumiyama-Shimomura N., Nakamura K., Aida J, Ishikawa N., Kuroiwa M., Hiraishi N., Fujiwara M., Ishikawa Y., Inoshita N., Yonese J., Masaaki Matsuura M., , Poon S. P., Arai T, Takubo K. : Urologic Oncology: Seminars and Original Investigations. Urol Oncol. (2014) 32: 135-145.

3.Telomere Lengths at Birth in Trisomy 18 and 21 Measured by Q-FISH. Nakamura K, Ishikawa N, Izumiyama N, Aida J, Kuroiwa M, Hiraishi N, Fujiwara M, Nakao A, Kawakami T, Poon SSS, Matsuura M, Sawabe M, Arai T, Takubo K. Gene. (2014)533: 199-207.

4.Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization. Terai M, Izumiyama-Shimomura N, Aida J, Ishikawa N, Kuroiwa M, Poon SS, Arai T, Toyoda M, Akutsu H, Umezawa A, Takubo K. Tissue & Cell (2013) 45: 407-413.

5.Age-related changes of Nrf2 and phosphorylated GSK-3b in a mouse model of accelerated aging (SAMP8). Tomobe K., Shinozuka T., Kuroiwa M., Nomura Y.: Archives of Gerontology and Geriatrics. (2012) 54: e1-e7.

6.Accelerated in vivo epidermal telomere loss in Werner syndrome. Ishikawa N., Nakamura K., Izumiyama-Shimomura N., Aida J., Ishii A., Goto M., Ishikawa Y., Asaka R., Matsuura M., Hatamochi A., Kuroiwa M. and Takubo K. : Aging. (2011) 3 (4): 417-429.

7.Immunohistochemical detection of haem oxygenase in AA amyloidosis. Kuroiwa M., K. Aoki, N. Izumiyama.: J. Elect. Microsc. (2004) 53 (4) : 417-422.

8.Histological study of experimental murine AA Amyloidosis. Kuroiwa M., K. Aoki, N. Izumiyama. : J. Elect. Microsc. (2003) 52 (4) : 407-413.

9.Role of CXC chemokines in the enhancement of LPS-induced neutrophil accumulation in the lung of mice by dexamethasone. Aoki K., Ishida Y., Kikuta N., Kawai H., Kuroiwa M., Sato M. : Biochem. Biophy. Res. Comm. (2002) 294 (5) : 1101-1108.

10.AA protein in experimental murine AA amyloid fibrils: a high resolution ultrastructural and immunohistochemical study comparing aldehyde-fixed and cryofixed tissues. Inoue S., Kuroiwa M., Kisilevsky R.: Amyloid : Int. J. Exp. Clin. Invest. (2002) 9 (2):115-125.

11.Basement membranes, microfibrils and amyloid fibrillogenesis in Alzheimer's disease: high resolution ultrastructral findings. Inoue S., Kuroiwa M., Kisilevsky R. : Brain Research Reviews (1999) 29(2): 218-231.

12.Ultrastructure of familial amyloid polyneuropathy amyloid fibrils : examination with high-resolution electron microscopy. Inoue S., Kuroiwa M., Saraiva M. J., A. Guimaraes A., Kisilevsky R.: J. Struct. Biol. (1998), 124 (1) : 1-12.

13.A high resolution ultrastructral comparison of isolated and in situ murine AA amyloid fibrils. Inoue S., Kuroiwa M., Tan R., Kisilevsky R.: Amyloid: Int. J. Exp. Clin. Invest. (1998) 5 (2): 99-110.

14.Ultrastructural organization of hemodialysis-associated 2-microglobulin amyloid fibrils. Inoue S., Kuroiwa M., Ohashi K., Hara M., Kisilevsky R.: Kidney Inter. (1997) 52 (6): 1543-1549.

15.Ultrastructure of the rat periodontal ligament as observed with quick-freeze, deep-etch and replica methods: arrangement of collagen and related structures. Kuroiwa M., Tachikawa T., Izumiyama N., Takubo K., Yoshiki S., Higashi S. : Acta. Anat. (1996) 157 (4): 291-302.

16.Electron microscopic studies on Sharpey's fibers in the alveolar bone of rat molars. Kuroiwa M., Chihara K., Higashi S.: Acta Anat Nippon. (1994) 69 (6) : 776-782.

入試情報 ADMISSION