教員紹介

篠塚 達雄
Shinozuka Tatsuo

所属・肩書

臨床薬学科/病態生理学研究室(特任教授)

最終学歴

北里大学大学院 薬学研究科 修士課程修了 (衛生化学専攻)

取得学位

薬学博士 (東京薬科大学)

所属学会

日本薬学会(代議員)、日本法医学会(評議員)、日本法中毒学会(評議員)、日本法科学技術学会(理事)

現在の専門分野

中毒学、分析化学、血液生理学、薬物動態学

現在の研究課題

●向精神薬の微量分析法開発と病態生理解析への応用
●生体試料中の生理機能関与因子の分析法開発と病態診断への応用

主要研究業績

●向精神薬の微量機器分析法
●中毒死亡例における薬毒物の検出とその意義に関する研究
●赤血球の生体内寿命に関する研究
●遺伝形質(血液型、DNA型、他)の解析と実務資料(親子鑑定・司法鑑定)への応用

最近の研究業績

1.A case of death caused by abuse of a synthetic cannabinoid N-1-naphthalenyl-1-pentyl-1H- indole-3-carboxamide. C.Sasaki, T.Saito, T.Shinozuka, W.Irie, C.Murakami, K.Maeada, N.Nakamura, M.Oishi, S.Nakamura and K.Kurihara. Forensic Toxicol. (2014 online)

2.Separation of sperm from mixed samples using ultra-high-speed cell sorter followed by DNA typing. A.Nakamura, T. Shinozuka, A. Sonoda, K. Kurosaki, K. Saito and A. Takada, Jpn.J.Forens.Scie. and Technol., 19, 45-55 (2014)

3.Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8. K.Tomobe, T. Shinozuka, T. Kawashima, Y. Kawashima-Ohya and Y. Nomura, Archi. Gerontol. Geriatrics, 57, 417–422 (2013)

4.Simultaneous determination of 5 psychotoropic drugs of various types in an autopsy case of acute multiple drug poisoning, C.Sasaki, T.Shinozuka, C.Murakami, W.Irie, K.Maeda, T.Watanabe, N.Nakamur, M.Furukawa, S.Nakamura, K.Kurihara, Forens. Sci. Int., 227, 90-94 (2013)

5.Analaysis of quazepam and its metabolites in human urine by gas chromatography/mass spectrometry:application to gorensic case, . M.Terada, T.Shinozuka, C.Hasegawa, E.Tanaka, M.Hayashida, Y.Ohno, K.Kurisaki, Forens. Sci. Int., 227, 95-99 (2013)

6.Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid-chromatography-tandem mass spectrometry, J.Shirako, M.Kawasaki, K.Komine, Y.Kunisue, M.Terada, C.Sasaki, W.Irie, C.Murakami, K.Tonooka, K.Tomobe and T.Shinozuka, Forens. Sci. Int., 227, 100-102 (2013)

7.Age-related changes of Nrf2 and phosphorylated GSK-3β in a mouse model of accerated aging (SAMP8), K.omobe, T.Shinozuka, M.Kuroiwa, Y.Nomura, Archives of Gerontology and Geriatrics. 54, e1-e7 (2012)

8.A case death due to inhalation of HFC-152a(1,1-Difluoroethane) with a peculiar derive, C. Sasaki, T. Shinozuka, W. Irie, T. Nakamae, C. Murakami, N. Nakamaru, M. Furukawa, S. Nakamura and K. Kurihara, Forensic Toxicol., 27, 45-48 (2009)

9.Etizolam and its major metabolites : Case Report, T. Nakamae, T. Shinozuka, C. Sasaki, A. Ogamo, C. Murakami-Hashimoto, W. Irie, M. Terada, S. Nakamura, M. Furukawa and K. Kurihara, Forensic Sci.Int. 182, e1-e6 (2008)

10.Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro, E. Tanaka, T. Nakamura, M. Terada, T. Shinozuka, K. Honda, J Clin Forensic Med, in press (2007)

11.Simple and simultaneous determination for 12 phenotiazines in human serum by reversed-phase high-performance liquid chromatography, E. Tanaka, T. Nakamura, M. Terada, T. Shinozuka, C. Hashimoto, K. Kurihara, K. Honda, J.Chromatogr. B , 854, 116-120 (2007)

12.Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method, T. Shinozuka, M. Terada, E. Tanaka :, Forensic Sci Int, 162, 108-112 (2006)

13.Rapid and simple analysis of oxazolobenzodiazepine drugs in sera by wide-bore capillary gas chromatography with nitrogen-phosphorus detection using on-column methylation, M. Terada, T. Shinozuka, E. Tanaka, K. Honda, K. Kurosaki, Forensic Toxicol, 24, 58-64 (2006)

14.A study of the in vitro interaction between ethanol, and triazolam and its two metabolites using human liver microsomes, E. Tanaka, T. Nakamura, M. Terada, T. Shinozuka, K. Honda, J Clin Forensic Med, 12, 245-248 (2005)

15.Preliminary study of the in vitro interaction between alchol, high-dose flunitrazepam and its three metabolites using human liver microsomes, E. Tanaka, T. Nakamura, M. Terada, T. Shinozuka, K. Honda, Basic & Clinical Pharmacology & Toxicology, 96, 88-90 (2005)

16.Reactivity of various recombinant human cytochrome P450 isomers for hydroxylation of triazolam in vitro, T. Shinozuka, K. Kurihara, K. Yamamoto, E. Tanaka, M.Terada, Jpn J Forensic Toxicl, 23, 205-208 (2005)

17.Simultaneous determination of flunitrazepam and 7-aminoflunitrazepam in human serum by ion trap gas chromatography-tandem mass spectrometry, M. Terada, S. Masui, T. Hayashi, R. Watanabe, H. Inoue, M. Iino, M. Nakatome, R. Matoba, T. Shinozuka, T. Murai, E. Tanaka, K. Honda, Legal Medicine, 5, S96-S100 (2003)

18.Colchicine posioning resulting from accidental ingetion meadow saffron (Colchicum Autumnale), S. Sannohe, Y. Makino, N. Kita, N. Kuroda, T. Shinozuka, J Forensic Sci., 47(6):1391-1396 (2002)

19.Expression of paraoxonase isoform did not confer protection from acute sarin poisoning in the Tokyo subway terrorist attack, Y. Yamada, T. Takatori, M. Nagao, H. Iwase, N. Kuroda, J. Yanagida, T. Shinozuka, Int J Legal Med, 115, 82-84 (2001)

著書及び総説

1.市川勤、岡野善郎、小野信文、小野寺憲治、神田循吉、重山昌人、篠塚達雄、島添隆雄、清水俊一、谷口良彦、土肥弘久、徳山雄一、原昭義、平野俊彦、松田佳和、松村峰博、若林広行:イラストで見る・疾病の成り立ちと薬物療法、医学評論社(2013)

2.薬毒物分析学辞典 分担(編集:高取健彦、黒岩幸雄、Anthony T.Tu、山本郁男) 廣川書店(2009)

3.薬毒物試験法と注解 2006  -分析・毒性・対処法― 分担:日本薬学会編 東京化学同人(2006)

4.Drugs and Poisons in Humans -Handbook of Practical Analysis- Propionic acid derivative analgesic-antipyretics (Eds : O.Suzuki, K.Watanabe) Springer (2006)

5.環境・健康科学辞典 分担:日本薬学会編 丸善 (2005)

入試情報 ADMISSION