教員紹介

出雲 信夫
Izumo Nobuo

所属・肩書

臨床薬学科/薬物治療学研究室、総合健康メディカル研究センター長(教授)

最終学歴

摂南大学薬学部博士後期課程

取得学位

博士(薬学)

所属学会

日本薬理学会(評議員)、日本神経精神薬理学会(評議員)、日本脳サプリメント学会(理事)、パクチーアカデミー協会(理事)、日本薬学会、日本骨代謝学会、日本ラクトフェリン学会、応用薬理研究会、日本脳科学会、神経化学会

現在の専門分野

薬理学

現在の研究課題

うつ病の発症メカニズムの解明と骨粗鬆症治療薬の検討

主要研究業績

●ステロイドホルモンや遺伝子の異常状態における行動の変化と抗うつ薬の効果の研究
Glob Drugs Therap, Volume 2(5): 1-5(2017) . Journal of Brain Science 46 5-19(2016) . Neurochemistry International.69:9-13(2014) . Behavioural Brain Research 227(1)1-6(2012) . Molecular Autism 3(11)1-9(2012)

●骨粗鬆症治療薬や機能性物質の骨代謝への効果の研究
Biol Pharm Bull 40, 1934-1940(2017) . J Pharmacol Sci 135 22-28(2017) . European Journal of Pharmacology 762 150-157(2015) . Lactoferrin 2015 114-119(2015) . International Journal of Sport and Health Science (4) 10-18(2006) . Methods Find Exp Clin Pharmacol 23(7) 389-394(2001) . Biochem Biophys Res Commun 280(1) 348-352(2001) . Jpn J Pharmacol 82(3) 240-246(2000)

●新規ナノステロイド製剤についての研究
Nippon Rinsho. Review. Japanese. 64(2) 329-334. (2006) . J Control Release 20(105)1-2 68-76(2005) . Ann Rheum Dis 64(8) 1132-1136(2005)

最近の研究業績

1. Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats. Izumo N, Yukiko I, Kagaya N, Furukawa M, Iwasaki R, Sumino A, Hayamizu K, Nakano M, Hoshino T, Kurono H, Watanabe Y, Manabe T, Current Molecular Pharmacology 14, 245-252(2021)

2. Therapeutic effects of sertraline on improvement of Ovariectomy-induced decreased spontaneous activity in mice. Furukawa M, Izumo N, Manabe T, Kurono H, Hayamizu K, Nakano M, Watanabe Y, Drug Discov Ther 15 (1), 28-34(2021)

3. Inhibitory Effects of Lotus Embryo Extract on Acetaminophen-induced Hepatic Injury. Izumo N, Furukawa M, Yonezawa M, Watanabe K, Kuroiwa M, Watanabe Y, Journal of Clinical and Medical Research 3 (5), 1-14(2021)

4. Zinc-containing Mohsʼ paste affects blood flow and angiogenesis suppression. Nagashima D, Furukawa M, Yamano Y, Yamauchi T, Okubo S, Toho M, Ito Y, Izumo N, DARU Journal of Pharmaceutical Sciences 1-8( 2021)

5. Estimation of inter-individual variability of protein requirement by indicator amino acid oxidation method, Hayamizu K, Aoki Y, Izumo N, Nakano M, J Clin Biochem Nutr 68 (1), 32-36(2021)

6. 卵巣摘出マウスでのロコモティブシンドローム類似変容に対する“新規女性保健薬”の改善効果. 古川恵, 出雲信夫, 上杉晴香, 植田愛美, 赤木淳二, 渡邉泰雄, 応用薬理 100, 33-39(2021) [特別掲載]

7. 弱酸性次亜塩素酸ナトリウム消毒液の安全性に関する研究(2):マウスを用いた長期吸入試験. 古川恵, 藤村礼,青木亮憲, 今井朝香, 大友彩華, 小澤由美, 渡邉泰雄, 出雲信夫, 応用薬理 100, 71-78(2021) [特別掲載]

8. 女神散は RANKL/OPG 比を抑制することにより卵巣摘出モデルマウスの骨強度低下を改善する. 古川恵, 出雲信夫, 吉澤佳那, 栗原優輝, 進藤広太郎, 平野可純, 東方優大, 日塔武彰, 飯塚徹, 渡邉泰雄, 応用薬理101 31-36(2021) [特別掲載]

9. Effects of Coriandrum sativum Seed Extract on Aging-Induced Memory Impairment in Samp8 Mice. Mima Y, Izumo N, Chen J-R, Yang S-C, Furukawa M, Watanabe Y, Nutrients 12 (2), 455(2020)

10. Continuous and Discontinuous Adherence to the Sticky Japanese Diet on Adiponectin and Leptin Regulation. Hirokawa Y, Izumo N, Tawara S, Aihara S, Obara R, Shimazu T, Tsuzuki K, Watanabe Y, Journal of Nutritional Health & Food Science 8 (1), 1-10(2020)

11. Effects of the combined administration of risedronate and menatetrenone on bone loss induced by tacrolimus in rats. Kanda J, Furukawa M, Izumo N, Shimakura T, Yamamoto N, Takahashi HE, Wakabayashi H, Drug Discoveries & Therapeutics 14 (2), 77-83(2020)

12. Effects of the linagliptin, dipeptidyl peptidase-4 inhibitor, on bone fragility induced by type 2 diabetes mellitus in obese mice. Kanda J, Furukawa M, Izumo N, Shimakura T, Yamamoto N, Takahashi HE, Wakabayashi H, Drug Discoveries & Therapeutics 14 (5), 218-225(2020)

13. Estimation of L-lysine Requirement by Indicator Amino Acid Oxidation Method Using Random Effects Model. Hayamizu K, Matsumoto K, Izumo N, Nakano M, International Journal of Nutrition and Food Sciences 9 (2), 63-68, 2020

14. ラクトフェリンの肥満誘発非アルコール性脂肪肝モデルマウスに及ぼす影響. 本間運人, 出雲信夫, 古川恵, 宮崎誠也, 櫻井潤, 桑原悠, 加賀谷伸治, 星野達雄, 渡邉 泰雄, 応用薬理 96, 93-99(2020)

15. 高脂肪食摂取マウスにおける内臓脂肪の経日的増量測定:小型動物用CT測定装置を用いて. 千葉輝正, 出雲信夫, 茅野大介, 宮館祐子, 松上拓矢, 山之内義弘, 加藤真介, 渡邉泰雄,応用薬理97, 27-32(2020)

16. 弱酸性次亜塩素酸ナトリウム消毒液の安全性に関する研究:マウスを用いた急性ならびに連続投与における肝機能への影響. 古川恵, 出雲信夫, 小原玲奈, 嶋津知美, 相原沙木, 渡邉泰雄, 応用薬理 99, 37-42(2020)

17. Effects of the Antiepileptic Drug Vigabatrin on Bone Strength, Bone Mineral Density, and Bone Turnover in Rats Junkichi Kanda, Nobuo Izumo, Megumi Furukawa, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E. Takahashi, Kenji Onodera, Hiroyuki Wakabayashi . Pharamacometrics 97 33-39(2019)

18. 高脂肪食摂取マウスにおける内臓脂肪の経日的増量測定:小型動物用CT測定装置を用いて 千葉 輝正, 出雲 信夫, 茅野 大介, 宮館 祐子, 松上 拓矢, 山之内 義弘, 加藤 真介, 渡邉 泰雄 . 応用薬理97 27-32(2019)

19. ラクトフェリンの肥満誘発非アルコール性脂肪肝モデルマウスに及ぼす影響 本間 運人, 出雲 信夫, 古川 恵, 宮崎 誠也, 櫻井 潤, 桑原 悠, 加賀谷 伸治, 星野 達雄, 渡邉 泰雄 . 応用薬理96 93-99(2019)

20. The Anti-Obesity Effect of Kaempferia Parviflora (KP) is Attributed to Leptin in Adipose Tissue Masaya Miyazaki, Nobuo Izumo, Kaoru Yoshikawa, Takuya Matsugami, Yuko Miyadate, Kohsuke Hayamizu1, Yasuo Watanabe . Journal of Nutritional Health & Food Science 7 (2) 1-9(2019)

21. Improvement of a Device for Measurement of Femoral Neck Bone Strength in Osteopenia Yu Kuwahara, Nobuo Izumo, Jun Sakurai, Kazuto Homma, Masaya Miyazaki, Megumi Furukawa, Makoto Nakano, Kohsuke Hayamizu, Yasuo Watanabe . Pharmacometrics 96 63-69(2019)

22. Effect of Coriandrum Sativum L. Leaf Extract on the Brain GABA Neurons in Mice Jun Sakurai, Nobuo Izumo, Yasuo Watanabe . Journal of Nutritional Health & Food Science 7 (2) 1-7(2019)

23. Anti-Obesity Effects of Sticky Japanese Diet (SJD) Assessed by Regulations of Leptin and Adiponectin Yoshiki Hirokawa, Nobuo Izumo, Masafumi Hashimoto, Shogo Tawara, Hiroshi Mori, Yurina Mima, Kensue Kuwahata, Kazuya Watanabe,Kimiko Tsuzuki, Yasuo Watanabe . Journal of Nutritional Health & Food Science 7 (1) 1-7(2019)

24. Safety assessment of L-lysine oral intake: a systematic review Kohsuke Hayamizu, Ikuyo Oshima, Zesoku Fukuda, Yui Kuramochi, Yuki Nagai, Nobuo Izumo, Makoto Nakano . Amino Acids 51, 647-659 (2019)

25. 高脂肪食摂取マウスの肥満に対する「ヌルねば食」の低減効果 俵翔 吾, 出雲 信夫, 吉川 馨, 宮崎 誠也, 櫻井 潤, 桑原 悠, 本間 運人, 廣川 佳貴, 美馬 優里奈, 桑畑 憲資, 渡辺 一哉, 都築 仁子, 渡邉 泰雄 . 応用薬理95 83-90(2018)

26. Efficts of lactoferrin on dexamethasone-induced osteoporosis in mice Nobuo Izumo, Shinfi Kagaya, Masahiro Toho, Megumi Furukawa, Yasuka Kabaya, Takao Hirai, Kohsuke Hayamizu, Makoto Nakano, Tatsuo Hoshino, Yasuo Watanabe . Global Drugs and Therapeutics 3 1-5(2018)

27. Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats Junkichi Kanda, Nobuo Izumo, Megumi Furukawa, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E. Takahashi, Toshinari Asakura, Hiroyuki Wakabayashi . Biomedical Research (Tokyo) 39 131-139(2018)

28. Effects of Multiple Comparisons on Integration of Stratified Analysis: On the Serum TG Decreasing Effect of EPA / DHA in Healthy Subjects Kohsuke Hayamizu, Nobuo Izumo, Makoto Nakano, Maki Matsuyama, Shigetoshi Tsuzuki, Yasuo Watanabe . Pharmacometrics 93 83-89(2017)

29. Effects of the Oral Intake of Kaempferia parviflora Extract on Whole Body Fat and Skeletal Muscle Percentages in Japanese Women: Randomized Double-Blind Placebo-Controlled Parallel Group Comparison Study Shigetoshi Tsuzuki, Makoto Nakano, Nobuo Izumo, Kohsuke Hayamizu, Maki Matsuyama, Yasuo Watanabe . Pharmacometrics 93 55-62(2017)

30. Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats Junkichi Kanda, Nobuo Izumo, Yoshiko Kobayashi, Kenji Onodera, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi, and Hiroyuki Wakabayashi . Biol Pharm Bull 40, 1934-1940(2017)

31. Treatment with Antiepileptic Agent Perampanel Suppresses Bone Formation and Enhances Bone Resorption: A Bone Histomorphometric Study in Mice Junkichi Kanda, Nobuo Izumo, Yoshiko Kobayashi, Kenji Onodera, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi and Hiroyuki Wakabayashi . J Hard Tissue biol 26(4) 405-410(2017)

32. Effects of the antiepileptic drugs topiramate and lamotrigine on bone metabolism in rats Junkichi KANDA, Nobuo Izumo, Yoshiko KOBAYASHI, Kenji ONODERA, Taketoshi SHIMAKURA, Noriaki YAMAMOTO, Hideaki E TAKAHASHI, and Hiroyuki WAKABAYASHI . Biomed Res (Tokyo) 38(5) 297-305 (2017)

33. Effect of the antidiabetic agent pioglitazone on bone metabolism in rats Junkichi Kanda, Nobuo Izumo, Yoshiko Kobayashi, Kenji Onodera, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi, Hiroyuki Wakabayashi . J Pharmacol Sci 135 22-28(2017)

34. MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors Izumo N, Ishibashi Y, Ono Y, Toho M, Sumino A, Kameyama T, Morikawa T, Shiba Y, Watanabe Y and Manabe T . Glob Drugs Therap, Volume 2(5): 1-5(2017)

35. Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation Katoh Shinsuke, Kobayashi Junya, Umeda Tomonobu, Kobayashi Yoshiko, Nobuo Izumo and Suzuki Takahiko . J Radi Res, pp. 1–7 doi: 10.1093/jrr/rrx032(2017)

36. Potentiation of nerve growth factor-induced neurite outgrowth by a novel SERM, MU314, PC12 cells Nobuo Izumo, Yukie Ono, Chinatsu Inatomi, Masahiro Toho, Shinsuke Katoh, Shigetoshi Tsuzuki, Takayuki Manabe, Yasuo Watanabe . Pharmacometrics 92 45-52(2017)

37. Fluvoxamine reverses estrogen-dependent decline in voluntary activitise and decreased and amygdala levels of serotonin in ovareectomized rats. Yukiko Ishibashi, Nobuo Izumo, Keiko Iwata, Tomomi Morikawa, Kameyama Toshiki, Yasuo Watanabe, Takayuki Manabe and Hideo Matsuzaki . Journal of Brain Science 46 5-19(2016)

38. X ray Irradiation Promotes Nerve Growth Factor-induced Neurite Extension in PC12 cells. Shinsuke Katoh, Junya Kobayashi, Tomonobu Umeda, Yoshiko Kobayashi, Nobuo Izumo, and Takahiko Suzuki B . RADIOISOTOPES, 65, 137-143(2016)

39. Application of Mohs’ Paste to Treat Hemorrhages Induced by Disintegrated Breast Cancer Tumors and Evaluation of this Hemostatic Mechanism Using an Animal Model. Nobuo Izumo, Masato Shigeyama, Maho Taguchi, Daichi Nagashima, Syota Nagano, Eri Kikuchi, Koji Hashiguchi, Jun Fujisawa. Mikio Murata, Takashi Isobe, Yasuhiro Kajiwara,
Kazuto Isuzugawa, Nobumitsu Hanioka, Yasuo Watanabe and Hitomi Teramachi . Japanese Journal of Pharmaceutical Health Care and Sciences, 42(4), 246-254(2016)

40. Modulation of osteoblast differentiation and bone mass by 5-HT2A receptor signaling in mice. Kenjiro Tanaka, Takao Hirai, Yukiko Ishibashi, Nobuo Izumo, Akifumi Togari . European Journal of Pharmacology 762 150-157(2015)

41. Integrated Analysis on Effect of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Fasting Serum Triglyceride Level in Borderline Subjects of Hyperlipidemia. Kohsuke Hayamizu, Nobuo Izumo, Maki Tsuji and Tomoko Tsuji . Pharmacometrics 88 97-103(2015)

42. Comparative Effects of between Stevia Fermented by Lactic Acid Bacteria (SW03) and Sugar on the Reduction of Errors of Calculations Induced by Fatigue in Human Study. Maki Tsuji, Nobuo Izumo, Hiroyuki Kuwahara, Shigetoshi Tsuzuki, Yasuo Watanabe . Pharmacometrics 88 81-86(2015)

43. Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades. Terada K, Izumo N, Suzuki B, Karube Y, Morikawa T, Ishibashi Y, Kameyama T, Chiba K, Sasaki N, Iwata K, Matsuzaki H, Manabe T. . Neurochemistry International.69:9-13(2014)

44. Addition of α-Glucosidase Inhibitors to the Dipeptidyl Peptidase-4 Inhibitor Alogliptin Has Rapid Synergistic Effects on Blood Incretin Levels. Jumpei Shikuma, Takaaki Kobayashi, Nobuo Izumo, Kenshi Kan, Atushi Kumakura, Rokuro Ito, Takashi Miwa, Akira Kanazawa, Masato Odawara. . Pharmacometrics 86 57-61(2014)

45. Prediction of inter-individual variability in pharmacokinetics of CYP2C19 substrates in humans. Chiba K, Shimizu K, Kato M, Nishibayashi T, Terada K, Izumo N, Sugiyama Y. . Drug Metabolism and Pharmacokinetics. 29(5) 379-86(2014)

46. Inhibition of nerve growth factor-induced neurite outgrowth from PC12 cells by dexamethasone: signaling pathways through the glucocorticoid receptor and phosphorylated Akt and ERK1/2. Terada K, Kojima Y, Watanabe T, Izumo N, Chiba K, Karube Y. . PLoS One. 9(3) e93223(2014)

著書及び総説

1.薬の効くプロセス(ネオメディカル)2017年

2.コンパス薬理学(南江堂)2017年

3.薬理学実習書(横浜薬科大学)2015年~

4.わかりやすい薬の効くプロセス 改訂版(ネオメディカル)2013年

5.薬剤師国家試験 -新国家試験形式 解答・解説集(横浜薬科大学)2011年~

6.Clinical Pharmaceutical English I(横浜薬科大学)2011年~

7.ファーマシューティカルノート 疾病と薬物治療学(医学評論社)2008年

入試情報 ADMISSION