教員紹介

速水 耕介
Hayamizu Kohsuke

所属・肩書

健康薬学科/食化学研究室、薬科学科/機能性物質学研究室、総合健康メディカル研究センター(教授)

最終学歴

九州大学大学院 生物資源環境科学府 博士後期課程修了

取得学位

博士(農学)(九州大学)

所属学会

●Society of Toxicology (US)
●American Society of Nutrition (US)
●American College of Nutrition (US)
●日本応用統計学会
●計算毒性研究会
●日本疫学会
●日本アミノ酸学会

現在の専門分野

食品機能学、食品安全学、生物統計学、バイオインフォマティクス

現在の研究課題

●機能性食品の有効性評価のための統計解析法
●タンパク質必要量の推定
●機能性食品のSystematic Review

主要研究業績

●Pre-Post試験データにおけるChange-Point Regression Model (CPRM) を用いた解析
●指標アミノ酸酸化法における変化点推定モデルの検討
●新規機能性食品の安全性評価方法の開発と安全性確保のための制度研究
●植物エキスによる抗肥満効果
●n-3系脂肪酸の脳機能に対する影響

最近の研究業績

1.Hayamizu K, Kuramochi Y, Furukawa M, Izumo N, Sumino A, Nakano M. Effects of inositol in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. J Nutr Health Fd Sci 2022 (in press)

2.Ishihara K, Sone H, Hayamizu K. Gradient boosting machine-based model for predicting hERG K+ channel inhibitory activities. J Comt Sci App & IT 2022 (in press)

3.Uchida K, Fujitani M, Mizushige T 4, Kawabata F, Hayamizu K, Uozumi K, Hara Y, Sawai M, Uehigashi R, Okada S, Goto-Inoue N, Morisasa M, Kishida T. Dietary Alaska pollack protein induces acute and sustainable skeletal muscle hypertrophy in rats. Nutrients 2022 (in press)

4.Kobuna S, Hayamizu K. A Change Point Regression Model for Treatment Effects Estimation of Functional Foods in a Pre-Post Design. J Nutr Health Fd Sci. 2021;9(1):1-7.

5.Furukawa M, Izumo N, Manabe T, Kurono H, Hayamizu K, Nakano M, Watanabe Y. Therapeutic effects of sertraline on improvement of Ovariectomy-induced decreased spontaneous activity in mice. Drug Discov Ther 2021;15, 28-34.

6.Izumo N, Ishibashi Y, Kagaya N, Furukawa M, Iwasaki R, Sumino A, Hayamizu K, Nakano M, HoshinoT, Kurono H, Watanabe Y, Manabe T. Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamineand Serotonin Release in the Amygdala of Ovariectomized Rats. Current Molecular Pharmacology, 2021; 14, 254-252.

7.Hayamizu K, Oshima I, Nakano., Comprehensive safety assessment of L-lysine supplementation from clinical studies: a systematic review. J Nutr 2020; 150,2561S-2569S.

8.Hayamizu K, Aoki Y, Izumo N, Nakano M. Estimation of inter-individual variability of protein requirement by indicator amino acid oxidation method. J Clin Biochem Nutr 2020; 68,32-36.

9.Hayamizu K, Matsumoto K, Izumo N, Nakano M. Estimation of L-lysine requirement by indicator amino acid oxidation method using random effects model. Int J Nutr Fd Sci. 2020; 9, 63-68.

10.速水耕介, 食品表示法とその一部改正, ファルマシア 2020; 56(2)153.

11.Fujita S, Kusano S, Sugiura Y, Sakuraba K, Kubota A, Sakuma K, Suzuki Y, Hayamizu K, Aoki Y, Sugita M. A 100-m sprint time is associated with deep trunk muscle thickness in collegiate male sprinters. Frontiers in Sports and Active Living. 2019; 1 article 32.

12.Miyazaki M, Izumo N, Yoshikawa K, Matsugami T, Miyadate Y, Hayamizu K, Watanabe Y. The anti-obesity effect of Kaempferia parviflora (KP) in attributed to leptin in adipose tissue. J Nutr Health Fd Sci. 2019; 7, 1-9.

13.Fujitani M, Mizushige T, Kawabata F, Uozumi K, Yasui M, Hayamizu K, Uchida K, Okada S, Keshab B, Kishida T. Dietary Alaska pollack protein improves recovery of skeletal muscle weight after atrophy induced by immobilization in rats. PLoS One. 2019; 14, e217917.

14.岸田太郎, 水重貴文, 川端二功, 速水耕介, 岡田晋治, 内田健志, 井上奈穂子, 藤谷美奈. 魚タンパク質の栄養と機能 -筋肉重量増加効果を中心に-. アミノ酸研究 2019; 13: 11-19.

15.出雲信夫, 小野香奈江, 加賀谷伸治, 古川 恵, 速水耕介, 中野真, 星野達雄, 渡邉泰雄. マウス成長骨の骨密度に対するラクトフ ェリンの効果. ラクトフェリン 2019, 77-82.

16.加賀谷伸治, 出雲信夫, 安福一嘉, 平野可純, 速水耕介, 中野 真,星野達雄, 佐藤 淳, 渡邉泰雄. 腹膜炎誘発モデルマウス成による炎症に対するラクトフェリンの効果. ラクトフェリン 2019, 97-100.

17.Kuwahara Y, Izumo N, Sakurai J, Honma K, Miyazaki M, FurukawaM, Nakano M, Hayamizu K, Watanabe Y. Improvement of device for measurement of fermoral neck bone strength in osteopenia. Pharmacometrics 2019; 96, 63-69.

18.Hayamizu K, Oshima I, Fukuda Z, Kuramochi Y, NagaiY, Izumo N, Nakano M. Safety assessment of L-lysine oral intake: systematic review. Amino Acids 2019; 51: 647-659.

19.速水耕介, EPA・DHA と脳機能.日本食品安全協会会誌 2019;14(2)114-120.

20.Izumo N, Kagaya S, Toho M, Furukawa M, Kabaya Y, Hirai T, Hayamizu K, Nakano M, Hoshino T, Watanabe Y. Effects of lactoferrin on dexamethasone-induced osteoporosis in mice. Glob Drugs Therap. 2018; 3, 1-5.

21.Hashimoto K, Kugo H, Tanaka H, Iwamoto K, Miyamoto C, Urano T, Unno N, Hayamizu K, Zaima N, Moriyama T. The effect of high fat diet on development of abdominal aortic aneurysm in vascular hypoperfusion-induced animal model. J Vasc Res 2018; 55, 63-74.

22.Hayamizu K, Izumo N, Nakano Matsuyama M, Tsuzuki S, Watanabe Y. Effects of Multiple Comparisons on Integration of Stratified Analysis: On the Serum TG Decreasing Effect of EPA / DHA in Healthy Subjects. Pharmacometrics 2017;93,p83-89.

23.Mizushige T, Komiya M, Onda M, Uchida K, Hayamizu K, Kabuyama Y. Fish protein hydrolysate exhibits anti-obesity and reduces hypothalamic neuropeptide Y and agouti-related protein mRNA expressions in rats. BioMed Res 2017:38, 351-357.

24.Tsuzuki S, Nakano M, Izumo N, Hayamizu K,Matsuyma M, Watanabe Y. Effects of the Oral Intake of Kaempferia parviflora Extract on Whole Body Fat and Skeletal Muscle Percentages in Japanese Women: Randomized Double-Blind Placebo-Controlled Parallel Group Comparison Study. Pharmacometrics. 2017;93,55-62.

25.Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T. Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm. Sci Rep. 2016:6:p31268.

26.Tsuchiya Y, Yanagimoto K, Nakazato K, Hayamizu K, Ochi E. Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint range of motion after eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial. Eur J Appl Physiol. 2016;116,1179-88.

27.中野 真, 飯野 智, 利根川美香, 速水耕介, 出雲信夫, 松山真貴, 山田明雄, 渡邉泰雄. 在宅医療における服薬指導の再確認. 応用薬理.2016;90,63-67.

28.Ayabe T, Mizushige T, Ota W, Kawabata F, Hayamizu K, Han L, Tsuji T, Kanamoto R, Ohinata K. Novel fish-derived peptide, which increases glucose uptake in skeletal muscle cells, lowers blood glucose in diabetic mice. Food Funct. 2015;8, 2749-57.

29.Hayamizu K, Izumo N, Tsuji M, Tsuji T Integrated analysis on effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on fasting serum triglyceride level in borderline subjects of hyperlipidemia. Pharmacometrics. 2015;89,97-103.

30.Ogawa A, Murayama H, Hayamizu K, Kobayashi Y, Kuwahata M, Kido Y. A Simple Evaluation Method for the Quality of Dietary Protein in Rats Using an Indicator Amino Acid Oxidation Technique. J Nutr Sci Vitaminol. 2015;61,123-130.

31.Kawabata F, Mizushige T, Uozumi K, Hayamizu K, Han L, Tsuji T, Kishida T. Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats. Biosci Biotechnol Biochem 2014;79:109-116.

32.Makino K, Isayama R, Hisamitsu I, Hayamizu K, Tsuji T, Shibata M, Preparation of Liposome Film With Pleasant Texture and High Water-Loss Suppression for Lip Care, J Jpn Soc Colour Mater 2013;86:243-246.

33.Konagai C, Yanagimoto K, Hayamizu K, Han L, Tsuji T, Koga Y, Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers, Clin Interv Aging 2013;8:1247-1257.

34.Kato M, Hattori S, Hayamizu K, Estimation of Amino Acid Requirement Adjusting for Carry-Over Effect Based on Approximate Change-Point Regression Model. Biomedical Research-india 2013; 24:216-222.

35.Ogawa A, Naruse Y, Shigemura Y, Kobayashi Y, Suzuki I, Wada S, Hayamizu K, Kuwahata M, Kido Y, An evaluation of protein intake for metabolic demands and the quality of dietary protein in rats using an indicator amino acid oxidation method, J Nutr Sci Vitaminol 2011;57:418-425.

36.Shigemi K, Tanaka K, Hayamizu K, D. Denbow DM , Furuse M, L-Serine decreases taurine concentration in the extracellular fluid of brain slice, Neurosci Med 2011;2:268-274.

37.Hayamizu K , Kato M, Hattori S , Determining amino acid requirements from repeated observations on indicator amino acid oxidation method by Mixed-Effect Change-Point Regression Models, J Clin Biochem Nutr 2011;49:115-120.

38.Torimitsu M, Nagase R, Yanagi M, Honma M, Sasai Y, Ito Y, Hayamizu K, Nonaka S, Kise M, Seki T, Ariga T, Replace the White Rice to Pre-germinated Brown Rice Mildly Ameliorates Postprandial Hyperglycemia and Imbalance of Adipocytokine Levels in Type 2 Diabetes Model Rat, J Nutr Sci Vitaminol 2010;56:287-292.

39.Shigemi K, Tsuneyoshi Y, Yamada S, Kabuki Y, Hayamizu K, Denbow DM, Furuse M, Oral administration of L-serine reduces the locomotor activity of socially isolated rats, Neuroscience Letters 2009;468:75-79.

40.石井有理,萬治愛子,速水耕介,大野智弘,塚本昭次郎,磯部英二,古瀬充宏,森山達哉. ケールがアルコール代謝に及ぼす効果について-フラッシャーを対象とした臨床研究およびマイクロアレイを用いた探索的基礎研究-, 日本臨床栄養学会誌 2009;30: 321-329.

41.本 三保子,五十嵐紘美,渭原 博,後藤彩子,速水耕介,岡村博貴, 橋詰直孝. ビタミン C 摂取方法による血清脂質及び尿中バイオピリンに及ぼす影響 日本臨床栄養学会誌 2009;30:235-243.

42.Kaneko I, Han L, Liu T , Li J , Zhao Y , Li C , Yi Y , Liang A , Hayamizu K. A 13-week subchronic oral toxicity study of L-serine in rats, Fd Chem Tox 2009;47:2356-2360.

43.Hayamizu K, Yamashita N, Hattori, Kakuma T. A change-point regression approach for efficacy evaluation of dietary supplement, J Clin Biochem Nutr 2009;44:285-290.

44.Kaneko I, Chiba T, Hayamizu K, Tsuji T. Effect of a Supplement containing Olive Leaf Extract against Ultraviolet Light-Induced Skin Pigmentation: A Double-Blind Placebo-Controlled Study, Anti-Aging Medicine 2008;5:78-81.

45.Shigemi K., Tsuneyoshi Y., Hamasu K., Han L., Hayamizu K, Denbow D. M., Furuse M. L-Serine induces sedative-hypnotic effects via GABAA receptor in neonatal chicks, Eur J Pharmacol 2008; 599:86-90.

46.Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MS and Yoshino G, Effects of Gacinia cambogia extract (hydroxycitric acid) on serum sex hormones in overweight subjects: A double-blind, randomized, placebo-controlled trial, Fitoterapia 2008;79:255-261.

47.Yamane H , Suenaga R , Han L, Hayamizu K , D. Denbow DM, Mitsuhiro Furuse M. Intracerebroventricular injection of glutathione related dipeptides induces sedative and hypnotic effects under an acute stress in neonatal chicks, Letters in Design & Discovery 2007;4:368-372.

48.Kurauchi I, Asechi M, Tachibana T, Han L, Hayamizu K, Denbow DM, Furuse M. Intracerebroventricular injection of tryptophan, but not lysine and methionine, induces a sedative effect under an acute stressful condition in neonatal chicks, J Appl Animal Res 2007;31: 25-28.

49.Kurauchi I, Asechi M, Tachibana T, Han L, Hayamizu K, Denbow DM, Furuse M. Intracerebroventricular injection of L-Alanine induces a sedative effect under an acute stressful condition in neonatal chicks, J Poult Sci 2006;43:384-387.

50.伊藤幸彦,申 曼珍,速水耕介,芳野 原,吉原理恵,横山淳一, 空腹時高血糖者の食後血糖,インスリン反応に及ぼす発芽玄米摂取の影響. 日本食品化学会誌 2005;12:80-84.

51.Asechi M, Tomonaga S , Tachibana T , Han L, Hayamizu K, Denbow DM , Furuse M. Intracerebroventricular injection of L-serine analogs and derivatives induces sedative and hypnotic effects under an acute stressful condition in neonatal chicks, Behav Brain Res 2006;170: 71-77.

52.Seki T, Nagase R, Torimitsu M, Yanagi M, Ito Y, Kise M, Mizukuchi A, Fujimura N, Hayamizu K, Ariga T. Insoluble fiber is major constituent responsible for lowering the post-prandial blood glucose concentration in the Pre-germinated brown rice. Biol. Pharm. Bull 2005;28,1539-1541.

53.Oikawa D, Hirakawa H, Hayamizu K, Nakamura Y, Shiba N, Nakanishi T, Iwamoto H, Tachibana T, Furuse M. Dietary Garcinia cambogia dose not modify skin properties of mice with or without excessive sucrose intake, Phytother Res 2005;19,294-297.

54.Koutoku T, Takahashi H, Tomonaga S, Oikawa D, Saito S, Tachibana T, Han L, Hayamizu K , Denbow DM and Furuse M. Central administration of phosphatidylserine attenuates isolation stress induced behavior in chicks. Neurochem Int 2005;47:183-189.

55.千葉友幸, 金子いづる, 速水耕介, 富田響子, 奥原康英, 名倉泰三,重松典宏. アトピー性皮膚炎患者に対するメリビオースの改善効果.アレルギーの臨床 2004;24:60-5.

56.Kon T, Tanigawa T, Hayamizu K, Shen MZ, Tsuji T, Naito Y, Yoshikawa T. Singlet oxygen quenching activity of human serum. Redox Rep 2004;9:325-30.

57.金子いづる, 速水耕介, 富田響子, 菊地裕人, 名倉泰三, 重松典宏, 千葉友幸, 思春期・成人アトピー性皮膚炎患者に対するメリビオースの初期臨床試験. J Appl Glycosci 2004;51:123-8.

58.Tamura A, Shiomi T, Okuhara Y, Hayamizu K, Shigematsu N, Kikuchi H, Hara H. The safety of high-dose repeated oral ingestion of difructose anhydride III in healthy humans. J Jpn Assoc dietary fiber Res 2003;7:89-96.

59.Ishii Y, Kaneko I, Shen M, Hayamizu K, Shigematsu N, Tomi H, Yoshino G, Shimasaki H. Safety of Garcinia cambogia extract in healthy volunteers.-High-doses administration study II- . J Oleo Sci 2003;52,663-71.

60.Hayamizu K, Ishii Y, Shigematsu N, Okuhara Y, Tomi H, Furuse M, Yoshino G, Shimasaki H. Safety of Garcinia cambogia extract in healthy men.-High-doses administration study I -. J Oleo Sci 2003; 52:499-504.

61.Hayamizu K, Ishii Y, Kaneko I, Shen M, Okuhara Y, Shigematsu N, Tomi H, Furuse M, Yoshino G, Shimasaki H. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation in humans: A double-blind, randomized, placebo-controlled trial. Curr Ther Res Clin Exp 2003;64:551-567.

62.Hayamizu K, Hirakawa H, Oikawa D, Nakanishi T, Takagi T, Tachibana T, Furuse M. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia 2003;74:267-73.

63.林 洋一, 山岡素子, 荻原典和, 岡本真由美, 朝岡 昭, 村上哲雄, 荒川泰行, 速水耕介. インスリン抵抗性が考えられる2型糖尿病におけるクロム補給の効果(第 2 報). Biomed Res Trace Elements 2002;13:310-311.

64.Hayamizu K, Ishii Y, Kaneko I, Shen M, Sakaguchi H, Okuhara Y, Shigematsu N, Shimasaki H. No-Observed-Adverse-Effect Level (NOAEL) and sequential-high-doses administration study on Garcinia cambogia extract in humans. J Oleo Sci 2002;51:365-69.

65.林 洋一, 岩崎聖子, 荻原典和, 岡本真由美, 朝岡 昭, 村上哲雄, 速水耕介, 荒川泰行. インスリン抵抗性が考えられる2型糖尿病におけるクロム補給の効果.Biomed Res Trace Elements 2001;12:307-308.

66.重松典宏, 申 曼珍, 速水耕介, 梶本修身. スギ花粉症に対する,甜茶, シソ含有食品(グミ)長期摂取投与による臨床的検討 -プ
ラセボを対照とした二重盲検比較試験-. 日本臨床栄養学会雑誌 2001;23:5-14.

67.Hayamizu K, Ishii Y, Kaneko I, Shen M, Sakaguchi H, Okuhara Y, Shigematsu N, Miyazaki S, Shimasaki H. Effect of long-term administration of Garcinia cambogia extracts on visceral at accumulation in human : A placebo-controlled double blind trial-. J Oleo Sci 2001;50:805-812.

著書及び総説

1.Hayamizu K: Amino Acids and Energy Metabolism: An Overview (Eds: Debasis Bagchi et al.), Sustained Energy for Enhanced Human Functions and Physical Activity pp339-349. 2017.

2.Hayamizu K, Manji A: Genomics, Proteomics and Metabolomics in Nutraceuticals and functional foods (Eds: Debasis Bagchi et al.), “Application of Genomics and Bio-informatics analysis in exploratory study of functional foods 2nd Edition”, pp.140-149, (WILEY-BLAKWELL US), 2015.

3.速水耕介:「EBM 実践のための統計学的 Q & A 」足立堅一 監訳,(Stastical questions in Evidence- Based Medicine, Bland M, Peacock J )第 9 章 “有意差検定”,pp94-103,篠原出版新書 2002年.

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