教員紹介

SDGsへの取り組み

最終学歴

大阪大学大学院　連合小児発達学研究科　後期博士課程修了

取得学位

博士（小児発達学）

所属学会

日本薬理学会、日本神経精神薬理学会、日本脳科学会

現在の専門分野

薬理学

現在の研究課題

●女性ホルモンの神経精神疾患及び発達障害に対する役割の解明
●機能性物質・食品の効果の解明

主要研究業績

●卵巣ホルモンによるセロトニン神経系調節機構の解明
●更年期障害の予防・治療に対する食品の効果の解明

最近の研究業績

1. Furukawa M, Izumo N, Toho M, Aoki R, Nishijima H, Nakamura Y, Sakai Y, Ishibashi Y, Kurono H, Manabe T, Matsuzaki H. The reduction in locomotor activity induced by restraint stress in young male mice involves the downregulation of hippocampal serotonergic and dopaminergic markers. IBRO Neurosci. Rep. 18, 726-731, 2025.

2. Furukawa M, Izumo N, Aoki R, Nagashima D, Ishibashi Y, Matsuzaki H. Behavioural changes in young ovariectomized mice via GPR30-dependent serotonergic nervous system. Eur. J. Neurosci. 60, 5658-5670, 2024.

3. Nagashima D, Mizukami N, Ogawa N, Suzuki S, Ohno M, Aoki R, Furukawa M, Izumo N. Bovine lactoferrin promotes neurite outgrowth in PC12 cells via the TrkA receptor. Int. J. Mol. Sci. 25, 11249, 2024.

4. Watanabe T, Yazaki M, Yazaki T, Furukawa M, Izumo N. Senotherapeutic effect of Agrimonia pilosa Ledeb. in targeting senescent cells in naturally aged mice. Food Bioscience 59, 103903, 2024.

5. Aoki R, Watanabe Y, Sakai Y, Furukawa M, Shigetomi T, Jiun Rong C, Izumo N. Wood cauliflower mushroom (Sparassis crispa) suppresses the body weight and visceral fat increased by ovariectomy in mice. Curr. Res. Food. Sci. 8, 100713, 2024.

6. Sakai Y, Yamada M, Watanabe T, Yamazaki A, Furukawa M, Izumo N, Matsuzaki H. Eurycomanone from Eurycoma longifolia Jack upregulates neurotrophin-3 gene expression in retinal Müller cells in vitro. J. Clin. Biochem. Nutr. 74, 23-73, 2023.

7. Nagashima D, Ishibashi Y, Kawaguchi S, Furukawa M, Toho M, Ohno M, Nitto T, Izumo N. Human Recombinant Lactoferrin Promotes Differentiation and Calcification on MC3T3-E1 Cells. Pharmaceutics 15, 60, 2022.

8. Nagashima D, Matsubara C, Mizukami N, Nakagawa A, Furukawa M, Toho M, Aoki R, Watanabe Y, Izumo N. Effect of Coriander on H2O2-induced Oxidative Stress in PC12 Cells. Med. Sci. Monit. 4(3), 115, 2022.

9. Hayamizu K, Kuramochi Y, Sumino A, Izumo N, Furukawa M, Nakano M. Effects of inositol in women with Polycystic Ovary Syndrome: A systematic review and meta-analysis of randomized controlled trials. J. Nutrit. Health Food Sci. 10(1), 1-8, 2022.

10. Toho M, Nagashima D, Komatsuzaki H, Furukawa M, Yamazoe M, Ohno M, Nitto T, Watanabe Y, Izumo N. Lactoferrin-mediated Changes in Melanin and Moisture Levels in UV-A Exposed Mice. Med. Sci. Monit. 4(1), 107, 2022.

11. Nagashima D, Furukawa M, Yamano Y, Yamauchi T, Okubo S, Toho M, Ito Y, Izumo N. Zinc-containing Mohs' paste affects blood flow and angiogenesis suppression. Daru. 29, 321-328, 2021.

12. Izumo N, Furukawa M, Yonezawa M, Watanabe K, Kuroiwa M, Watanabe Y. Inhibitory Effects of Lotus Embryo Extract on Acetaminophen-induced Hepatic Injury. Med. Sci. Monit. 3(5), 087, 2021.

13. Furukawa M, Izumo N, Manabe T, Kurono H, Hayamizu K, Nakano M, Watanabe Y. Therapeutic effects of sertraline on improvement of Ovariectomy-induced decreased spontaneous activity in mice. Drug Discov. Ther. 15, 28-34, 2021.

14. Izumo N, Yukiko I, Kagaya N, Furukawa M, Iwasaki R, Sumino A, Hayamizu K, Nakano M, Hoshino T, Kurono H, Watanabe Y, Manabe T. Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats. Curr. Mol. Pharmacol. 14, 245-252, 2021.

15. Kanda J, Furukawa M, Izumo N, Shimakura T, Yamamoto N, Takahashi HE, Wakabayashi H. Effects of the linagliptin, dipeptidyl peptidase-4 inhibitor, on bone fragility induced by type 2 diabetes mellitus in obese mice. Drug Discov. Ther. 14, 218-225, 2020.

16. Kanda J, Furukawa M, Izumo N, Shimakura T, Yamamoto N, Takahashi HE, Wakabayashi H. Effects of the combined administration of risedronate and menatetrenone on bone loss induced by tacrolimus in rats. Drug Discov. Ther. 14, 77-83, 2020.

17. Mima Y, Izumo N, Chen JR, Yang SC, Furukawa M, Watanabe Y. Effects of Coriandrum sativum Seed Extract on Aging-Induced Memory Impairment in Samp8 Mice. Nutrients. 12, 455, 2020.

18. Kuwahara Y, Izumo N, Sakurai J, Homma K, Miyazaki M, Furukawa M, Nakano M, Hayamizu K, Watanabe Y. Improvement of a Device for Measurement of Femoral Neck Bone Strength in Osteopenia. Pharmacometrics 96, 63-69, 2019.

19. Kanda J, Izumo N, Furukawa M, Shimakura T, Yamamoto N, Takahashi HE, Onodera K, Wakabayashi H. Effects of the Antiepileptic Drug Vigabatrin on Bone Strength, Bone Mineral Density, and Bone Turnover in Rats. Pharmacometrics 97, 33-39, 2019.

20. Kanda J, Izumo N, Furukawa M, Shimakura T, Yamamoto N, Takahashi H, Asakura T, and Wakabayashi H. Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats. Biomedical Research (Tokyo) 39 (3), 131–139, 2018.

21. Izumo N, Kagaya S, Toho M, Furukawa M, Kabaya Y, Hirai T, Hayamizu K, Nakano M, Hoshino T and Watanabe Y. Effects of lactoferrin on dexamethasone-induced osteoporosis in mice. Glob Drugs Therap 3(3), 1-5, 2018.