教員紹介

SDGsへの取り組み

最終学歴

九州大学大学院 薬学研究科 博士課程修了(衛生化学・裁判化学専攻)

取得学位

薬学博士(九州大学)

所属学会

日本薬学会、日本薬物動態学会、日本毒性学会

現在の専門分野

薬物代謝学、衛生薬学、分子毒性学

現在の研究課題

●薬物代謝酵素の分子的・機能的多様性
●環境化学物質の代謝の個人差
●植物エストロゲンの生体内運命
●食品-医薬品の相互作用の分子機序

主要研究業績

●変異型薬物代謝酵素の機能変化
●内分泌かく乱化学物質の代謝
●植物エストロゲンの代謝

最近の研究業績

【2012年以降の原著論文】
1. Hanioka N*, Isobe T, Saito K, Nagaoka K, Mori Y, Jinno H, Ohkawara S, Tanaka-Kagawa T. Hepatic glucuronidation of tetrabromobisphenol A and tetrachlorobisphenol A: interspecies differences in humans and laboratory animals and responsible UDP-glucuronosyltransferase isoforms in humans. Arch Toxicol. 2024; 98(3):837-848. doi: 10.1007/s00204-023-03659-1.

2．Isobe T, Ohkawara S, Mori Y, Jinno H, Tanaka-Kagawa T, Hanioka N*. Hydrolysis of dibutyl phthalate and di(2-ethylhexyl) phthalate in human liver, small intestine, kidney, and lung: An in vitro analysis using organ subcellular fractions and recombinant carboxylesterases. Chem Biol Interact. 2023;372:110353. doi: 10.1016/j.cbi.2023.110353.

3．Mori Y, Tanaka-Kagawa T, Tahara M, Kawakami T, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, Azuma K, Sakai S, Jinno H. Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality. J Toxicol Sci. 2023;48(1):37-45. doi: 10.2131/jts.48.37.

4．Mori Y, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, Tanaka-Kagawa T, Jinno H. Species-specific activation of transient receptor potential ankyrin 1 by phthalic acid monoesters. Biol Pharm Bull. 2022;45(12): 1839-1846. doi: 10.1248/bpb.b22-00645.

5．Mori Y, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, Tanaka-Kagawa T, Jinno H. Isoform-specific quantification of human bitter taste receptor transcripts using real-time PCR analysis. Biol Pharm Bull. 2022;45(8):1185-1190. doi: 10.1248/bpb.b22-00292.

6．Hanioka N*, Tanaka-Kagawa T, Mori Y, Ikushiro S, Jinno H, Ohkawara S, Isobe T. Regioselective glucuronidation of flavones at C5, C7, and C4´ positions in human liver and intestinal microsomes: comparison among apigenin, acacetin, and genkwanin. Biol Pharm Bull. 2022;45(8):1116-1123. doi: 10.1248/bpb.b22-00160.

7．Kitaguchi T, Mizota T, Ito M, Ohno K, Kobayashi K, Ogawa I, Qiu S, Iwao T, Hanioka N, Tanaka M, Matsunaga T. Simultaneous evaluation of membrane permeability and UDP-glucuronosyltransferase-mediated metabolism of food-derived compounds using human induced pluripotent stem cell-derived small intestinal epithelial cells. Drug Metab Dispos. 2022;50(1):17-23. doi: 10.1124/dmd.121.000605.

8．Hanioka N*, Isobe T, Tanaka-Kagawa T, Jinno H, Ohkawara S. In vitro glucuronidation of bisphenol A in liver and intestinal microsomes: interspecies differences in humans and laboratory animals. Drug Chem Toxicol. 2022;45(4):1565-1569. doi: 10.1080/01480545.2020.1847133.

9．Hanioka N*, Saito K, Isobe T, Ohkawara S, Jinno H, Tanaka-Kagawa T. Favipiravir biotransformation in liver cytosol: species and sex differences in humans, monkeys, rats, and mice. Biopharm Drug Dispos. 2021;42(5):218-225. doi: 10.1002/bdd.2275.

10．Hanioka N*, Isobe T, Tanaka-Kagawa T, Ohkawara S. Wogonin glucuronidation in liver and intestinal microsomes of humans, monkeys, dogs, rats, and mice. Xenobiotica. 2020;50(8):906-912. doi: 10.1080/00498254.2020.1725180.

11．Isobe T, Ohkawara S, Ochi S, Tanaka-Kagawa T, Hanioka N*. S-equol glucuronidation in liver and intestinal microsomes of humans, monkeys, dogs, rats, and mice. Food Chem Toxicol. 2019;131:110542. doi: 10.1016/j.fct.2019.05.050.

12．Tanaka-Kagawa T, Saito I, Onuki A, Tahara M, Kawakami T, Sakai S, Ikarashi Y, Oizumi S, Chiba M, Uemura H, Miura N, Kawamura I, Hanioka N, Jinno H. Method validation for the determination of phthalates in indoor air by GC-MS with solid-phase adsorption/solvent extraction using octadecyl silica filter and styrene–divinylbenzene copolymer cartridge. BPB Repotrs. 2019;2:86–90. doi: 10.1248/bpbreports.2.5_86

13．Hanioka N*, Isobe T, Ohkawara S, Ochi S, Tanaka-Kagawa T, Jinno H. Hydrolysis of di(2-ethylhexyl) phthalate in humans, monkeys, dogs, rats, and mice: an in vitro analysis using liver and intestinal microsomes. Toxicol In Vitro. 2019;54:237–242. doi: 10.1016/j.tiv.2018.10.006.

14．Taguchi M, Shigeyama M, Ogawa N, Murata M, Hanioka N, Yamamoto H, Teramachi H. Evaluation of tumor tissue fixation effects of formulation modified Mohs pastes in mice and their water-absorbing properties. Biol Pharm Bull 2018;41(12):1824–1829. doi: 10.1248/bpb.b18-00528.

15．Hanioka N*, Ohkawara S, Isobe T, Ochi S, Tanaka-Kagawa T, Jinno H. Regioselective glucuronidation of daidzein in liver and intestinal microsomes of humans, monkeys, rats, and mice. Arch Toxicol 2018;92(9):2809–2817. doi: 10.1007/s00204-018-2265-1.

16．Isobe T, Ohkawara S, Ochi S, Tanaka-Kagawa T, Jinno H, Hanioka N*. Naringenin glucuronidation in liver and intestine microsomes of humans, monkeys, rats, and mice. Food Chem Toxicol 2018;111:417–422. doi: 10.1016/j.fct.2017.11.057.

17．Miyata-Nozaka Y, Mohd Zain S, Taguchi M, Shigeyama M, Isobe T, Hanioka N*. Carbamazepine 10,11-epoxidation in human liver microsomes: influence of the CYP3A5*3 polymorphism. Pharmazie 2017;72 (12):747–450. doi: 10.1691/ph.2017.7754.

18．Taguchi M, Shigeyama M, Ito N, Ogawa N, Takahashi C, Murata M, Hanioka N, Yamamoto H, Teramachi H. Preparation and Evaluation of Modified Mohs Paste without Starch. Yakugaku Zasshi 2017;137(4):477–484. doi: 10.1248/yakushi.16-00248.

19．Isobe T, Ohkawara S, Tanaka-Kagawa T, Jinno H, Hanioka N*. Hepatic glucuronidation of 4-tert-octylphenol in humans: inter-individual variability and responsible UDP-glucuronosyltransferase isoforms. Arch Toxicol 2017;91(11):3543–3550. doi: 10.1007/s00204-017-1982-1.

20．Hanioka N*, Isobe T, Ohkawara S, Tanaka-Kagawa T, Jinno H. Glucuronidation of 4-tert-octylphenol in humans, monkeys, rats, and mice: an in vitro analysis using liver and intestine microsomes. Arch Toxicol 2017;91(3):1227–1232. doi: 10.1007/s00204-016-1800-1.

21．Hanioka N*, Kinashi Y, Tanaka-Kagawa T, Isobe T, Jinno H. Glucuronidation of mono(2-ethylhexyl) phthalate in humans: roles of hepatic and intestinal UDP-glucuronosyltransferases. Arch Toxicol 2017;91(2):689–698. doi: 10.1007/s00204-016-1708-9.

22．Hanioka N*, Isobe T, Kinashi Y, Tanaka-Kagawa T, Jinno H. Hepatic and intestinal glucuronidation of mono(2-ethylhexyl) phthalate, an active metabolite of di(2-ethylhexyl) phthalate, in humans, dogs, rats and mice: an in vitro analysis using microsomal fractions. Arch Toxicol 2016;90(7):1651–1657. doi: 10.1007/s00204-015-1619-1.

23．Kishi N, Takasuka A, Kokawa Y, Isobe T, Taguchi M, Shigeyama M, Murata M, Suno M, Hanioka N*. Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8, and UGT1A9. Xenobiotica 2016;46(4):289–295. doi: 10.3109/00498254.2015.1074301.

24．Miyake Y, Hirose R, Isobe T, Hanioka N*. Molecular cloning and functional analysis of minipig UDP-glucuronosyltransferase 1A6. Xenobiotica 2016;46(3):193–199. doi: 10.3109/00498254.2015.1060373.

25．Isobe T, Kofuji K, Okada K, Fujimori J, Murata M, Shigeyama M, Hanioka N, Murata Y. Adsorption of histones on natural polysaccharides: the potential as agent for multiple organ failure in sepsis. Int J Biol Macromol. 2016: 84:54–57. doi: 10.1016/j.ijbiomac.2015.11.029.

26．Mukai M, Isobe T, Okada K, Murata M, Hanioka N*. Species and sex differences in propofol glucuronidation in liver microsomes of humans, monkeys, rats and mice. Pharmazie 2015;70 (7):466–470. doi: 10.1691/ph.2015.5525.

27．Mukai M, Tanaka S, Yamamoto K, Murata M, Okada K, Isobe T, Shigeyama M, Hichiya H, Hanioka N*. In vitro glucuronidation of propofol in microsomal fractions from human liver, intestine and kidney: tissue distribution and physiological role of UGT1A9. Pharmazie 2014;69(11):829–832. doi: 10.1691/ph.2014.4564.

28．Yamamoto K, Mukai M, Nagaoka K, Hayashi K, Hichiya H, Okada K, Murata M, Shigeyama M, Narimatsu S, Hanioka N*. Functional characterization of cynomolgus monkey UDP-glucuronosyltransferase 1A9. Eur J Drug Metab Pharmacokinet 2014;39(3):195–202. DOI 10.1007/s13318-014-0177-x

29．Takahara Y, Kinashi Y, Takahara Y, Hichiya H, Okada K, Murata M, Shigeyama M, Hanioka N*. Butylbenzyl phthalate hydrolysis in liver microsomes of humans, monkeys, dogs, rats and mice. Biol Pharm Bull 2014;37(4):703–706.

30．Kuze J, Mutoh T, Takenaka T, Oda N, Hanioka N, Narimatsu S. Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam. Xenobiotica 2013;43(7):598–606. doi: 10.3109/00498254.2012.751517.

31．Kokawa Y, Kishi N, Jinno H, Tanaka-Kagawa T, Narimatsu S, Hanioka N*. Effect of UDP-glucuronosyltransferase 1A8 polymorphism on raloxifene glucuronidation. Eur J Pharm Sci. 2013;49(2):199–205. doi: 10.1016/j.ejps.2013.03.001.

32．Mayumi K, Hanioka N, Masuda K, Koeda A, Naito S, Miyata A, Narimatsu S. Characterization of marmoset CYP2B6: cDNA cloning, protein expression and enzymatic functions. Biochem Pharmacol. 2013;85(8):1182–1194. doi: 10.1016/j.bcp.2013.01.024.

33．Miyake Y, Mayumi K, Jinno H, Tanaka-Kagawa T, Narimatsu S, Hanioka N*. cDNA cloning and functional analysis of minipig UDP-glucuronosyltransferase 1A1. Biol Pharm Bull 2013;36(3):452–461.

34．Hanioka N*, Takahara Y, Takahara Y, Tanaka-Kagawa T, Jinno H, Narimatsu S. Hydrolysis of di-n-butyl phthalate, butylbenzyl phthalate and di(2-ethylhexyl) phthalate in human liver microsomes. Chemosphere 2012;89(9):1112–1117. doi: 10.1016/j.chemosphere.2012.05.095.

35．Nagaoka K, Hanioka N, Ikushiro S, Yamano S, Narimatsu S. The effects of N-glycosylation on the glucuronidation of zidovudine and morphine by UGT2B7 expressed in HEK293 cells. Drug Metab Pharmacokinet 2012;27(4):388–397.

36．Hanioka N*, Nonaka Y, Saito K, Kataoka H, Narimatsu S. Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells. Chemosphere 2012;89(5):526–529. doi: 10.1016/j.chemosphere.2012.05.039.

37．Hanioka N*, Tanaka S, Moriguchi Y, Narimatsu S. Stereoselective glucuronidation of carvedilol in human liver and intestinal microsomes. Pharmacology 2012;90(3–4):117–124. doi: 10.1159/000340020.

38．Hanioka N*, Iwabu H, Hanafusa H, Nakada S, Narimatsu S. Expression and inducibility of UDP-glucuronosyltransferase 1As in MCF-7 human breast carcinoma cells. Basic Clin Pharmacol Toxicol 2012;110(3):253–258. doi: 10.1111/j.1742-7843.2011.00790.x.

外部競争的研究資金

【2011年度以降の研究代表者】
1．科学研究費（基盤研究C）(日本学術振興会）：異物代謝酵素の多様性に基づく化学物質のオーダーメイド型リスク評価システムの構築，2023～2025年度.

2．科学研究費（基盤研究B）(日本学術振興会）：異物応答因子を基軸とする生活環境中化学物質の革新的なリスク評価システムの構築，2019～2022年度.

3．科学研究費（挑戦的研究・萌芽）(日本学術振興会）：化学物質の個別化リスク評価法の開発：人工カクテル異物代謝酵素を用いる戦略，2018～2020年度.

4．科学研究費（基盤研究B）（日本学術振興会）:異物代謝酵素に着眼した化学物質の暴露経路依存的なリスク評価法の構築，2014～2016年度.

5．住友財団・環境研究助成:人工カクテル異物代謝酵素を用いる環境汚染物質のハイスループット毒性評価法の構築，2013年度.

6．科学研究費（基盤研究C）（日本学術振興会）:異物代謝能の個人差を考慮した化学物質のリスク評価法の開発研究，2011～2013年度.

著書及び総説

【2012年以降】
1．埴岡伸光：コンパス衛生薬学 -健康と環境- 改訂第3版（編集: 鍜冶利幸, 佐藤雅彦），“化学物質の毒性”，pp. 26-145，南江堂，2020年. ISBN: 978-4-524-40371-4.

2．埴岡伸光：衛生薬学新論 改訂第2版（編集: 新井洋由, 成松鎭雄, 山田英之），“化学物質の毒性”，pp. 345-362，南山堂，2012年. ISBN: 978-4-525-74492-2.