教員紹介

大河原 晋
Ohkawara Susumu

所属・肩書

健康薬学科/公衆衛生学研究室(教授)

最終学歴

北陸大学大学院 薬学研究科 博士課程修了

取得学位

薬学博士

所属学会

日本薬学会、日本毒性学会、日本微量栄養素学会

現在の専門分野

分子毒性学

現在の研究課題

●生活環境化学物質の毒性発現に対する分子機序の解明
●香気成分の生理機能およびその分子機序の解明

主要研究業績

●重金属の血管および神経毒性に関する研究
●揮発性有機化学物質のTRPイオンチャネル機能に関する研究
●プロスタサイクリン合成酵素の産生調節機構に関する研究

最近の研究業績

1.Wada, M., Wada, M., Ikeda, R., Fuchigami, Y., Koyama, H., Ohkawara, S., Kawakami, S., Kuroda, N., Nakashima, K. Quantitative and antioxidative behavior of Trolox in rats' blood and brain by HPLC-UV and SMFIA-CL methods. Luminescence (2016) 31(2), 414-8.

2.Mizuno, D., Konoha-Mizuno, K., Mori, M., Sadakane, Y., Koyama, H., Ohkawara, S., Kawahara, M. Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia. Metallomics (2015) 7(8), 1233-9.

3.Mizuno, D., Koyama, H., Ohkawara, S., Sadakane, Y., Kawahara, M. Involvement of trace elements in the pathogenesis of prion diseases. Curr. Pharm. Biotechnol. (2014) 15(11), 1049-57.

4.Kawahara, M., Mizuno, D., Koyama, H., Konoha, K., Ohkawara, S., Sadakane, Y. Disruption of zinc homeostasis and the pathogenesis of senile dementia. Metallomics (2014) 6, 209-19.

5.Kawahara, M., Sadakane, Y., Koyama, H., Konoha, K., Ohkawara, S. D-Histidine and L-histidine attenuate zinc-induced neuronal death in GT1-7 cells. Metallomics (2013) 6, 209-19.

6.Kawahara, M., Konoha, K., Koyama, H., Ohkawara, S., Sadakane, Y. Zinc and neurodegenerative diseases. InTech Neurodegenerative Diseases. (2013) 519-533.

7.Ohkawara, S., Tanaka-Kagawa, T., Furukawa, Y., Jinno, H. Methylglyoxal activates the human transient receptor potential ankyrin 1 channel. J. Toxicol. Sci. 37, (2012) 831-835.

8.Kawahara, M., Koyama, H., Ohkawara, S., Kato-Negishi, M. Disruption of calcium homeostasis in Alzheimer’s disease: role of channel formation by β Amyloid Protein, InTech Neurodegenerative Diseases (2011) 115-134.6

9.Koyama, H., Konoha, K., Sadakane, Y., Ohkawara, S., Kawahara, M. Zinc neurotoxicity and the pathogenesis of vascular-type dementia: Involvement of calcium dyshomeostasis and carnosine, J. Clinic. Toxicol. (S3 doi: 10.4172/2161-0495.S3-002) (2011).

10.大城なつき、小山裕也、中村亜紀子、大河原晋、川原正博. アロマセラピー精油の不死化視床下部神経細胞に対する作用 Trace Nutrients Research (2011) 28, 49-53.

11.Ohkawara, S., Tanaka-Kagawa, T., Furukawa, Y., Nishimura, T., Jinno, H. Development of a SYBR green real-time polymerase chain reaction assay for quantitative detection of human N-methyl-D-aspartate receptor subtype 1 splice variants. J. Health. Sci. (2010) 33, 1434-1437.

12.Ohkawara, S., Tanaka-Kagawa, T., Furukawa, Y., Nishimura, T., Jinno, H. Activation of the human transient receptor potential vanilloid subtype 1 by essential oils. Biol. Pharm. Bull. 33, (2010) 1434-1437.

13.Ohkawara, S., Okuma, Y., Uehara, T., Yamagishi, T., Nomura, Y. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur. J. Pharmacol. (2005) 525(1-3), 41-7.

14.Yokoyama, C., Todaka, T., Yanamoto, H., Hatae, T., Hara, S., Shimonishi, M., Ohkawara, S., Wada, M., Tanabe, T. Effects of overexpression of prostacyclin synthase in vascular smooth muscle cells. Adv. Exp. Med. Biol. (2002).507, 275-280.

15.Ohkawara, S., Yokoyama, C., Shimonishi, M., Tanabe, T. Analysis of the transcriptional regulation of mouse prostacyclin synthase gene. Adv. Exp. Med. Biol. (2002) 507, 281-286.

16.Yokoyama, C., Yabuki, T, Shimonishi., M, Wada., M., Hatae, T., Ohkawara, S., Takeda, J., Kinoshita, T., Okabe, M., Tanabe, T. Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. Circulation (2002) 106(18), 2397-2403.

17.Ohkawara, S., Yokoyama, C., Shimonishi,, M Tanabe, T. Analysis of 5’-flanking region of mouse prostacyclin synthase gene. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury (Honn, K. V., Marnett, L. J. Nigam, S eds. Plemum press, New York) (2001) 5, 357-361.

18.Ohkawara, S., Shimonishi, M., Tanabe, T., Yokoyama, C. Cloning and characterization of 5’-flanking region of mouse prostacyclin synthase gene. Biochim. Biophys. Acta (2000) 1494, 155-161.

受賞

●平成27年度 第32回日本薬学会九州支部学術奨励賞
●平成27年度 第42回日本毒性学会学術年会ファイザー賞
●平成25年度 第30回日本薬学会九州支部優秀発表賞
●平成25年度 室内環境学会学術大会ポスター賞

入試情報 ADMISSION