三木 涼太郎
Miki Ryotaro
薬学教育センター(講師)
SDGsへの取り組み
最終学歴
城西大学大学院 薬学研究科 博士課程 修了
取得学位
博士（薬学）城西大学
所属学会
日本薬学会、日本DDS学会、日本薬剤学会
現在の専門分野
物理薬剤学、製剤学
現在の研究課題
糖・pH変化などの刺激に応答して粘弾性が変化するスマート材料の研究
主要研究業績
1. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Phenylboronate-salicylate ester cross-linked self-healing hydrogel composed of modified hyaluronan at physiological pH, Soft Matter, 20: 2926–2936 (2024).
2. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Anomalous glucose-responsive rheological changes in a boronic acid-modified hyaluronan, Chem. Commun., 59: 5114-5117 (2023).
3. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Hydrogen peroxide-responsive micellar transition from spherical to worm-like in cetyltrimethylammonium bromide/3-fluorophenylboronic acid/fructose system, Colloids Surfaces A Physicochem. Eng. Asp., 648: 129418 (2022).
4. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Diol responsive viscosity increase in a cetyltrimethylammonium bromide/sodium salicylate/3-fluorophenylboronic acid micelle system, RSC Adv., 12: 6668-6675 (2022).
5. H. Kikuchi, Y. Nakamura, C. Inoue, S. Nojiri, M. Koita, M. Kojima, H. Koyama, R. Miki, T. Seki, Y. Egawa, Hydrogen peroxide-triggered conversion of boronic acid-appended insulin into insulin and its application as a glucose-responsive insulin formulation, Mol. Pharm., 18:4224-4230 (2021).
6. R. Miki, T. Yamauchi, K. Kawashima, Y. Egawa, T. Seki, Multinuclear NMR study on the formation and polyol-induced deformation mechanisms of worm-like micelles composed of cetyltrimethylammonium bromide and 3-fluorophenylboronic acid, Langmuir, 37: 3438-3445 (2021).
7. Y. Kobayashi, Y. Kojima, R. Miki, T. Seki, Y. Egawa, Rotaxa-polymeric-gelation of acrylamides with vinyl-β-cyclodextrin, J. Incl. Phenom. Macrocycl. Chem., 98: 43-48 (2020).
8. Y. Ohno, T. Seki, Y. Kojima, R. Miki, Y. Egawa, O. Hosoya, K. Kasono, T. Seki, Investigation of factors that cause insulin precipitation and/or amyloid formation in insulin formulations, J. Pharm. Health Care Sci., 5: 22 (2019).
9. Y. Ohno, M. Kawakami, T. Seki, R. Miki, T. Seki, Y. Egawa, Cell adhesive character of phenylboronic acid-modified insulin and its potential as long-acting insulin, Pharmaceuticals, 12: 121 (2019).
10. Y. Kobayashi, Y. Kojima, R. Miki, T. Seki, T. Fujihara, Y. Ishimaru, Y. Egawa, Single-step preparation of topological gels using vinyl-modified β-cyclodextrin as a figure-of-six cross-linker, J. Incl. Phenom. Macrocycl. Chem., 92: 311-317 (2018).
11. C. Takei, Y. Ohno, T. Seki, R. Miki, T. Seki, Y. Egawa, Sugar-responsive layer-by-layer film composed of phenylboronic acid-appended insulin and poly(vinyl alcohol), Chem. Pharm. Bull., 66: 368-374 (2018).
12. R. Miki, C. Takei, Y. Ohtani, K. Kawashima, A. Yoshida, Y. Kojima, Y. Egawa, T. Seki, D. Iohara, M. Anraku, F. Hirayama, K. Uekama, Glucose responsive rheological change and drug release from a novel worm-like micelle gel formed in cetyltrimethylammonium bromide/phenylboronic acid/water system, Mol. Pharm., 15:1097-1104 (2018).
13. R. Miki, Y. Hara, N. Imai, M. Sugino, Y. Egawa, O. Hosoya, K. Juni, T. Seki, A study on an in vitro changeable pH dissolution/permeation system that reflects pH shifts of the gastrointestinal tract: a case of a poorly soluble basic drug, AATEX, 22:107-114 (2017).
14. W. Uchida, M. Yoshikawa, T. Seki, R. Miki, T. Seki, T. Fujihara, Y. Ishimaru, Y. Egawa, A polyrotaxane gel using boronic acid-appended γ-cyclodextrin as a hybrid cross-linker, J. Incl. Phenom. Macrocycl. Chem., 89: 281-288 (2017).
15. Y. Hazama, W. Uchida, T. Maekawa, R. Miki, S. Oshima, Y. Egawa, O. Hosoya, T. Seki, Preclinical study of tacrolimus ointment for prevention of its systemic absorption in atopic dermatitis model mice according to their skin conditions, Jpn. J. Pharm. Health Care Sci., 43: 477-491 (2017).
16. Y. Kojima, T. Okano, T. Seki, M. Namiki, Y. Egawa, R. Miki, K. Juni, T. Seki, Polyol-responsive pseudopolyrotaxanes based on phenylboronic acid-modified polyethylene glycol and cyclodextrins, J. Incl. Phenom. Macrocycl. Chem., 87:295-303 (2017).
17. R. Miki, Y. Kobayashi, Y. Nakamura, T. Asaka, N. Imai, Y. Hirayama, O. Hosoya, Y. Egawa, T. Seki, The development of a novel in vitro gastrointestinal absorption model comprising drug dissolution/migration/permeation processes: interactions between a drug and an excipient, AATEX, 21:1-13 (2016).
18. T. Seki, K. Abe, Y. Egawa, R. Miki, K. Juni, T. Seki, A pseudopolyrotaxane for glucose-responsive insulin release: The effect of binding ability and spatial arrangement of phenylboronic acid group, Mol. Pharm., 13:3807-3815 (2016).
19. N. Shimomura, Y. Egawa, R. Miki, T. Fujihara, Y. Ishimaru, T. Seki, Red fluorophore comprising of a borinate-containing xanthene analogue as a polyol sensor, Org. Biomol. Chem., 14:10031-10036 (2016).
20. T. Seki, M. Namiki, Y. Egawa, R. Miki, K. Juni, T. Seki, Sugar-responsive pseudopolyrotaxane composed of phenylboronic acid-modified polyethylene glycol and γ-cyclodextrin, Materials, 8: 1341-1349 (2015).
21. Y. Hazama, T. Maekawa, R. Miki, S. Oshima, Y. Egawa, K. Morimoto, T. Seki, Effect of physiological changes in the skin on systemic absorption of tacrolimus following topical application in rats, Biol. Pharm. Bull., 39:343-352 (2016).
22. T. Seki, K. Abe, K. Nakamura, Y. Egawa, R. Miki, K. Juni, T. Seki, Sugar-responsive pseudopolyrotaxanes and their application in sugar-induced release of PEGylated insulin, J. Incl. Phenom. Macrocycl. Chem., 82:417-424 (2015).
23. R. Miki, Y. Ichitsuka, T. Yamada, S. Kimura, Y. Egawa, T. Seki, K. Juni, H. Ueda, Y. Morimoto, Development of a membrane impregnated with a poly(dimethylsiloxane)/poly(ethylene glycol) copolymer for a high-throughput screening of the permeability of drugs, cosmetics, and other chemicals across the human skin, Eur. J. Pharm. Sci., 66: 41-49 (2015).
24. K. Shinohara, M. Yamashita, W. Uchida, S. Oshima, Y. Egawa, R. Miki, O. Hosoya, T. Kishino, T. Seki, K. Juni, Preparation of polypseudorotaxanes composed of cyclodextrin and polymers in microspheres, Chem. Pharm. Bull., 62: 962-966 (2014).
25. K. Nakamura, T. Seki, Y. Egawa, R. Miki, Y. Oda, T. Yamanoi, T. Seki, Suger-Sensitive Supramolecular Structures Based on Phenylboronic Acid-Modified Cyclodextrins, Chem. Pharm. Bull., 61: 1188-1191 (2013).
26. 木村聡一郎, 宮崎香織, 三木涼太郎, 島村剛史, 沼尻幸彦, 関俊暢, 從二和彦, 北野博巳, 上田秀雄, 森本雍憲, 皮膚適用製剤の製剤試験法に利用可能なヒト皮膚代替膜としての高分子人工膜の評価, 薬剤学, 71:191-196 (2011).
27. R. Miki, S. Kimura, H. Ueda., T. Shimamura, S. Numajiri, T. Seki, K. Juni, H. Kitano, Y. Morimoto, Suitability of synthetic copolymer membranes as a human skin alternative for in vitro skin permeation testing, AATEX, 15: 14-27 (2010).
最近の研究業績
1. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Phenylboronate-salicylate ester cross-linked self-healing hydrogel composed of modified hyaluronan at physiological pH, Soft Matter, 20: 2926–2936 (2024).
2. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Anomalous glucose-responsive rheological changes in a boronic acid-modified hyaluronan, Chem. Commun., 59: 5114-5117 (2023).
3. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Hydrogen peroxide-responsive micellar transition from spherical to worm-like in cetyltrimethylammonium bromide/3-fluorophenylboronic acid/fructose system, Colloids Surfaces A Physicochem. Eng. Asp., 648: 129418 (2022).
4. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Diol responsive viscosity increase in a cetyltrimethylammonium bromide/sodium salicylate/3-fluorophenylboronic acid micelle system, RSC Adv., 12: 6668-6675 (2022).
5. H. Kikuchi, Y. Nakamura, C. Inoue, S. Nojiri, M. Koita, M. Kojima, H. Koyama, R. Miki, T. Seki, Y. Egawa, Hydrogen peroxide-triggered conversion of boronic acid-appended insulin into insulin and its application as a glucose-responsive insulin formulation, Mol. Pharm., 18:4224-4230 (2021).
6. R. Miki, T. Yamauchi, K. Kawashima, Y. Egawa, T. Seki, Multinuclear NMR study on the formation and polyol-induced deformation mechanisms of worm-like micelles composed of cetyltrimethylammonium bromide and 3-fluorophenylboronic acid, Langmuir, 37: 3438-3445 (2021).
受賞
● 2022年度 日本薬学会関東支部奨励賞
● 2nd World Congress on Oleo Science (WCOS2022), WCOS 2022 Excellent Presentation Award
● 日本油化学会 オレオマテリアル部会 2018年オレオマテリアル賞
● 日本動物実験代替法学会 AATEX 2016年優秀論文賞
著書及び総説
【著書】
1. T. Seki, R. Miki, Related Topic: Measurement of Diffusion Coefficient of Chemicals.“Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds”, Springer Japan, Tokyo, 2017, pp.377-384.
2. 関 俊暢, 三木 涼太郎, “ＤＤＳ製剤の開発・評価と実用化手法”, 安保公介編, p. 110-114, 技術情報協会(東京), (2013).
【総説】
1. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Diol or hydrogen peroxide-responsive micellar systems and their rheological properties, J. Oleo Sci., 73: 611–618 (2024).
2. 三木 涼太郎 新規機能性材料に向けたジオール化合物に応答して構造転移するミセル系と粘弾性特性変化, YAKUGAKU ZASSHI, 143: 559-563 (2023).
3. Y. Egawa, T. Seki, R. Miki, T. Seki, Sugar-responsive smart materials based on phenylboronic acid and cyclodextrin, J. Incl. Phenom. Macrocycl. Chem., 94: 1-10 (2019).
4. 三木 涼太郎, フェニルボロン酸を用いたグルコース応答性新規紐状ミセルゲルの調製と薬物放出特性, オレオサイエンス, 19: 5-11 (2019).
5. Y. Egawa, R. Miki, T. Seki, Colorimetric Sugar Sensing Using Boronic Acid-Substituted Azobenzenes, Materials, 7: 1201-1220 (2014).
最近の学会発表
1. 三木 涼太郎，八巻 努，内田 昌希，夏目 秀視，フェニルボロン酸/サリチル酸エステルにより架橋されたセルフヒーリングヒドロゲルの調製，日本薬学会第144年会，横浜（2024）
2. 三木 涼太郎，八巻 努，内田 昌希，夏目 秀視，グルコース濃度に応じてゲル化/ゾル化するボロン酸修飾ヒアルロン酸粘弾性体，第20回 ホスト-ゲスト・超分子化学シンポジウム，八王子（2023）
3. 三木 涼太郎，新規機能性材料に向けたジオール化合物に応答して構造転移するミセル系と粘弾性特性変化，第66回日本薬学会関東支部大会，横浜（2022）
4. R. Miki, T. Yamaki, M. Uchida, H. Natsume, Hydrogen peroxide-responsive rheological change in cetyltrimethylammonium bromide/3-fluorophenylboronic acid/fructose micellar system, 2nd World Congress on Oleo Science, 釧路 (オンライン開催)（2022）
5. 三木 涼太郎，八巻努，内田昌希，夏目秀視，ジオール化合物に応答し粘性が増加する臭化セチルトリメチルアンモニウム/サリチル酸ナトリウム/3-フルオロフェニルボロン酸混合ミセル系の調製，日本薬学会第142年会，名古屋（オンライン）（2022）
6. 三木 涼太郎、谷田部 香、江川 祐哉、関 俊暢、カチオン性界面活性剤/フェニルボロン酸混合系における分子集合体形成と糖検出への応用、第63回日本薬学会関東支部大会、港区（2019）
7. 三木 涼太郎、塩野 さやか、山崎 聖仁、江川 祐哉、関 俊暢、臭化セチルトリメチルアンモニウム/3-フルオロフェニルボロン酸混合系中の分子集合体構造の解明に向けたレオロジー特性調査、日本薬学会第139年会、千葉（2019）
