教員紹介

礒部 隆史
Isobe Takashi

所属・肩書

健康薬学科/公衆衛生学研究室(准教授)

最終学歴

岡山大学大学院自然科学研究科博士後期課程修了

取得学位

博士(薬学)

所属学会

日本薬学会、日本薬剤学会、日本DDS学会、高分子学会、日本キチン・キトサン学会、日本機能性食品医用学会

現在の専門分野

物理薬剤学、薬物代謝学、衛生化学

現在の研究課題

●敗血症性多臓器不全の治療におけるアルギン酸の有効性に関する研究
●薬物代謝酵素に基づく薬物-薬物相互作用の予測に関する研究

主要研究業績

●天然高分子の製剤学的利用に関する研究
●シトクロムP-450の遺伝子多型並びに薬物相互作用に関する研究

最近の研究業績

1.Isobe T., Kofuji K., Okada K., Fujimori J., Murata M., Shigeyama M., Hanioka N., Murata Y. Adsorption of histones on natural polysaccharides: The potential as agent for multiple organ failure in sepsis. International Journal of Biological Macromolecules 2015: in press.

2.Hanioka N., Isobe T., Kinashi Y., Tanaka-Kagawa T., Jinno H. Hepatic and intestinal glucuronidation of mono(2-ethylhexyl) phthalate, an active metabolite of di(2-ethylhexyl) phthalate, in humans, dogs, rats and mice: an in vitro analysis using microsomal fractions. Archives of Toxicology 2015: in press.

3.Kishi N., Takasuka A., Kokawa Y., Isobe T., Taguchi M., Shigeyama M., Murata M., Suno M., Hanioka N. Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8, and UGT1A9. Xenobiotica 2015: in press.

4.Miyake Y., Hirose R., Isobe T., Hanioka N. Molecular cloning and functional analysis of minipig UDP-glucuronosyltransferase 1A6. Xenobiotica, 2015, in press.

5.Mukai M., Isobe T., Okada K., Murata M., Shigeyama M., Hanioka N. Species and sex differences in propofol glucuronidation in liver microsomes of humans, monkeys, rats and mice. Pharmazie, 2015, 70, 466–470 (2015)

6.Mukai M., Tanaka S., Yamamoto K., Murata M., Okada K., Isobe T., Shigeyama M., Hichiya H., Hanioka N. In vitro glucuronidation of propofol in microsomal fractions from human liver, intestine and kidney: tissue distribution and physiological role of UGT1A9. Pharmazie, 69, 829–832 (2014)

7.Isobe T., Kofuji K., Murata Y. Characteristics of drug release from gel beads formed by hydrolysis of alginic acid into guluronic acid blocks. Chem. Pharm. Bull. 61, 967–970 (2013)

8.Murata Y., Isobe T., Kofuji K., Nishida N., Kamaguchi R. Development of film dosage forms containing miconazole for the treatment of oral candidiasiss. Pharmacology and Pharmacy 4, 325–330 (2013)

9.Kofuji K., Aoki A., Tsubaki K., Konishi M., Isobe T., Murata M. Antioxidant activity of β-glucan. ISRN Pharmaceutics 2012, 1–5 (2012) (doi:10.5402/2012/125864)

10.Murata Y, Isobe T, Kofuji K, Mizutani M, Kamaguchi R. Development of oral dissolving gelation beads containing allopurinol for the prevention and treatment of mucositis. Pharmacology and Pharmacy 3, 303–307 (2012)

11.Murata Y, Isobe T, Kofuji K, Nishida N, Kamaguchi R. Preparation of Fast Dissolving Films for Oral Dosage from Natural Polysaccharides. Materials 3, 4291–4299 (2010)

12.Kofuji K, Huang Y, Tsubaki K, Kokido F, Nishikawa K, Isobe T, Murata Y. Preparation and evaluation of a novel wound dressing sheet comprised of β-glucan–chitosan complex. Reactive and Functional Polymers 70, 784–789 (2010)

13.Kofuji K, Isobe T and Murata Y. Controlled release of alpha-lipoic acid through incorporation into natural polysaccharide-based gel beads. Food Chem 115, 483–487 (2009)

14.Murata Y, Kodama Y, Isobe T, Kofuji K and Kawashima S. Drug release profile from calcium-induced alginate-phosphate composite gel beads. Int J Poly Sci., 2009, 1–4 (2009) (doi:10.1155/2009/729057)

15.Kofuji K, Nakamura M, Isobe T, Murata Y and Kawashima S. Stabilization of α-lipoic acid by complex formation with chitosan. Food Chem 109, 167–171 (2008)

16.Murata Y, Jinno D, Liu D, Isobe T, Kofuji K and Kawashima S. The Drug Release Profile from Calcium-induced Alginate Gel Beads Coated with an Alginate Hydrolysate. Molecules 12, 2559–2566(2007)

17.Saito Y. , Hanioka N., Maekawa K., Isobe T., Tsuneto Y., Nakamura R., Soyama A., Ozawa S., Tanaka-Kagawa T., Jinno H., Narimatsu S., Sawada J. Functional analysis of three CYP1A2 variants found in Japanese population. Drug Metab Dispos 33, 1905–1910 (2005)

18.Narimatsu S, Oda M, Hichiya H, Isobe T, Asaoka K, Hanioka N, Yamano S, Shinoda S, Yamamoto S. Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2. Chemico-Biol. Interact. 152, 1–12 (2005)

19.Isobe T, Hichiya H, Hanioka N, Yamamoto S, Shinoda S, Funae Y, Satoh T, Yamano S and Narimatsu S. Different effects of desipramine on bufuralol 1"-hydroxylation by rat and human CYP2D enzymes. Biol Pharm Bull 28, 634–640 (2005)

20.Masuda K, Tamagake K, Okuda Y, Torigoe F, Tsuzuki D, Isobe T, Hichiya H, Hanioka N, Yamamoto S and Narimatsu S. Change in enantioselectivity in bufuralol 1"-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6. Chirality 17, 37–43 (2005)

21.Masuda K, Hashimoto H, Tamagake K, Okuda Y, Tsuzuki D, Isobe T, Hichiya H, Hanioka N, Yamamoto S and Narimatsu S. Changes in the enzymatic properties of CYP2D6 by the substitution of phenylalanine at position 120 by alanine. J Health Sci 50, 503–510 (2004)

22.Narimatsu S, Imoto K, Isobe T, Kiryu K, Naito S, Hichiya H, Funae Y, Hanioka N and Yamamoto S. The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2. Biochem Biophys Res Commun 324, 627–633 (2004)

外部競争的研究資金

●科学研究費(若手研究B)(日本学術振興会):敗血症性多臓器不全の治療におけるアルギン酸の有効性,2014~2015年.

入試情報 ADMISSION