教員紹介

越智 定幸
Ochi Sadayuki

所属・肩書

健康薬学科/感染予防学研究室(教授)

最終学歴

徳島文理大学大学院

取得学位

博士(薬学)

所属学会

日本細菌学会、毒素シンポジウム

現在の専門分野

基礎数学

現在の研究課題

●下痢原性大腸菌の分子疫学解析
●下痢原性細菌の病原性獲得機構

主要研究業績

●ウエルシュ菌α毒素の溶血作用機序に関する研究
●毒素原性大腸菌H10407株の病原プラスミドの配列解析
●発展途上国における感染性下痢症の疫学解析

最近の研究業績

1.An outbreak of diarrhea in Mandera, Kenya, due to Escherichia coli serogroup O-nontypable strain that had a coding gene for enteroaggregative E. coli heat-stable enterotoxin 1. Sadayuki Ochi, Mohammad Shah, Erick Odoyo, Martin Bundi, Gabriel Miringu, Sora Guyo, Ernest Wandera, Cyrus Kathiiko, Samuel Kariuki, Mohamed Karama, Takao Tsuji, Yoshio Ichinose. Am. J. Trop. Med. Hyg. 96(2), 457-464 (2017)2017

2.Recent insights into Clostridium perfringens beta-toxin. Masahiro Nagahama, Sadayuki Ochi, Masataka Oda, Kazuaki Miyamoto, Masaya Takehara, Keiko Kobayashi. Toxins (Basel), 7(2), 396-406 (2015)

3.A recombinant carboxy-terminal domain of alpha-toxin protects mice against Clostridium perfringens. Masahiro Nagahama, Masataka Oda, Keiko Kobayashi K, Sadayuki Ochi, Teruhisa Takagishi, Masahiro Shibutani and Jun Sakurai. Microbiol. Immunol., 57(5), 340-345 (2013)

4.P19 embryonal carcinoma cells exhibit high sensitivity to botulinum type C and D/C mosaic neurotoxins. Kentaro Tsukamoto, Hideyuki Arimitsu, Sadayuki Ochi, Keiji Nakamura, Yoshikazu Tanaka, Nipawan Nuemket, Koki Taniguchi, Shunji Kozaki and Takao Tsuji. Microbiol. Immunol., 56(10), 664-672 (2012)

5.Role of sphingomyelinase in infectious diseases caused by Bacillus cereus. Masataka Oda, Manabu Hashimoto, Masaya Takahashi, Yuka Ohmae, Soshi Seike, Ryoko Kato, Aoi Fujita, Hideaki Tsuge, Masahiro Nagahama, Sadayuki Ochi, Teppei Sasahara, Shunji Hayashi, Yoshikazu Hirai and Jun Sakurai. PLoS One, 7(6), e38054 (2012)

6.Role of phospholipid metabolism and G protein in the action induced by Clostridium perfringens alpha-toxin. Masahiro Nagahama, Masataka Oda, Sadayuki Ochi, Keiko Kobayashi and Jun Sakurai. J. Glycom. Lipidom., 2 (3), S3-001 (2012)

7.Recent insights into Clostridium perfringens alpha-toxin. Masahiro Nagahama, Masataka Oda, Sadayuki Ochi, Keiko Kobayashi and Jun Sakurai. Res. Adv. Infect. Immun., 1, 1-12 (2011)

8.Nucleotide sequence analysis of the enterotoxigenic Escherichia coli Ent plasmid. Sadayuki Ochi, Tohru Shimizu, Kaori Ohtani, Yoshio Ichinose, Hideyuki Arimitsu, Kentaro Tsukamoto, Michio Kato and Takao Tsuji. DNA Res., 16 (5), 299-309 (2009)

9.Lincomycin-induced over-expression of mature recombinant cholera toxin B subunit and the holotoxin in Escherichia coli. Hideyuki Arimitsu, Kentaro Tsukamoto, Sadayuki Ochi, Keiko Sasaki, Michio Kato, Koki Taniguchi, Keiji Oguma and Takao Tsuji. Protein Expr. Purif., 67(2), 96-103 (2009)

10.The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens α-toxin. Masataka Oda, Takayuki Matsuno, Ryouta Shiihara, Sadayuki Ochi, Rieko Yamauchi, Yuki Saito, Hiroshi Imagawa, Masahiro Nagahama, Mugio Nishizawa and Jun Sakurai. J. Lipid Res., 49 (5), 1039-1047 (2008)
11.Molecular properties of each subcomponent in Clostridium botulinum type B haemagglutinin complex. Hideyuki Arimitsu, Yoshihiko Sakaguchi, Jae-Chul Lee, Sadayuki Ochi, Kentaro Tsukamoto, Yumiko Yamamoto, Shaobo Ma, Takao Tsuji and Keiji Oguma. Microb. Pathog., 45 (2), 142-149 (2008)
12.A nasal vaccine comprising B-subunit derivative of Shiga toxin 2 for cross-protection against Shiga toxin types 1 and 2. Takao Tsuji, Takeshi Shimizu, Keiko Sasaki, Kentaro Tsukamoto, Hideyuki Arimitsu, Sadayuki Ochi, Toshiyasu Shimizu, Koki Taniguchi, Masatoshi Noda, Paola Neri and Hiroshi Mori. Vaccine, 26 (17), 2092-2099 (2008)

13.Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin. Takao Tsuji, Takeshi Shimizu, Keiko Sasaki, Yoshiyasu Shimizu, Kentaro Tsukamoto, Hideyuki Arimitsu, Sadayuki Ochi, Satoshi Sugiyama, Koki Taniguchi, Paola Neri, Hiroshi Mori. Vaccine, 26 (4), 469-476 (2008)

14.Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. Hideo Ago, Masataka Oda, Masaya Takahashi, Hideaki Tsuge, Sadayuki Ochi, Nobuhiko Katunuma, Masashi Miyano and Jun Sakurai. J. Biol. Chem., 281 (23), 16157-16167 (2006)

15.A mutant of Escherichia coli enterotoxin inducing a specific Th1-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNγ-stimulated macrophages. Toshiyasu Shimizu, Keiko Sasaki, Michio Kato, Hideyuki Arimitsu, Sadayuki Ochi, Tomomasa Yano, Keizi Oguma, Takashi Yokochi and Takao Tsuji. Vaccine, 24 (18), 3719-3726 (2006)

16.Mutant Escherichia coli enterotoxin as a mucosal adjuvant induces specific Th1 responses of CD4+ and CD8+ T cells to nasal killed-bacillus calmette-guerin in mice Hiroki Takahashi, Keiko Sasaki, Miyuki Takahashi, Naoko Shigemori, Shyunichi Honda, Hideyuki Arimitsu, Sadayuki Ochi, Naoya Ohara and Takao Tsuji. Vaccine, 24 (17), 3591-3598 (2006)

入試情報 ADMISSION