教員紹介

川嶋 剛
Kawashima Tsuyoshi

所属・肩書

薬科学科/分子生物学研究室、健康薬学科/分子生物学研究室(教授)

最終学歴

総合研究大学院大学 生命科学研究科 博士課程単位取得退学 (遺伝学専攻)

取得学位

薬学博士 (九州大学)

所属学会

日本薬学会、日本分子生物学会、日本遺伝学会

現在の専門分野

分子生物学

現在の研究課題

●好熱性古細菌の環境適応遺伝子群の探索とそれらの転写制御機構の解明
●生体内酸化還元関連タンパク質の転写調節機構の解明
●食道癌細胞に対するファージ単鎖(scFv)モノクローナル抗体の作製

主要研究業績

●日本産野生マウスのヘモグロビンβ鎖遺伝子(Hbb)の地理的分布
●好熱性古細菌Thermoplasma volcaniumの全ゲノム塩基配列決定と情報科学的解析
●好熱性古細菌の環境適応遺伝子群の転写制御機構の解析
●抗プリオンタンパク質に対するファージ単鎖(ScFv)モノクローナル抗体の作製

最近の研究業績

1.Apoptosis occurs during early development of the bursa of Fabricius in chicken embryos. Makino K, Omachi R, Suzuki H, Tomobe K, Kawashima T, Nakajima T.,and Kawashima-Ohya Y. Biol. Pharm. Bull. 2014;37(12):1982-5.

2.Specificity of Fur Binding to the Oxidative Stress Response Gene Promoter in the Facultative Anaerobic Archaeon Thermoplasma volcanium. Minoshima H, Ikeda Y, Fujii M, Satoh M, Ishikawa T, Kawashima-Ohya Y, Tomobe K, Itoh Y, Omata Y, Kawashima T. Biol. Pharm. Bull. 37(3) 481-485, 2014.

3.Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8. Tomobe K, Shinozuka T, Kawashima T, Kawashima-Ohya Y, Nomura Y. Arch Gerontol Geriatr. 2013 Nov-Dec;57(3):417-422.

4.Transcriptional factor Fur from Thermoplasma volcanium binds its own promoter DNA in a divalent cation-dependent manner. Y. Ikeda, H. Minoshima, M. Satoh, T. Ishikawa, Y. Kawashima-Ohya, K. Tomobe, Y. Omata and T. Kawashima, J. Gen. Appl. Microbiol., 58, 465-473 (2012).

5.The DNA-recognition mode shared by archaeal feast/famine-regulatory proteins revealed by the DNA-binding specificities of TvFL3, FL10, FL11 and Ss-Lrp. K. Yokoyama, H. Nogami, M. Kabasawa, S. Ebihara, A. Simowasa, K. Hashimoto, T. Kawashima, S. A. Ishijima and M. Suzuki, Nucleic Acids Res., 37(13), 4407-4419 (2009)

6.Feast/Famine regulation by transcription factor FL11 for the survival of the hyperthermophilic archaeon Pyrococcus OT3, K. Yokoyama. S. A. Ishijima, H. Koike, C. Kurihara, A. Shimowasa, M. Kabasawa, T. Kawashima and M. Suzuki, Structure, 15, 1542-1554 (2007)

7.A Structural Code for Discriminating between Transcription Signals Revealed by the Feast/Famine Regulatory Protein DM1 in Complex with Ligands. H. Okumura, K. Yokoyama, H. Koike, M. Yamada, A. Shimowasa, M. Kabasawa, T. Kawashima and M. Suzuki, Structure, 15, 1-14 (2007)

8.Characterization and expression analysis of a chicken interleukin-6 receptor alpha. N. Nishimichi, T. Kawashima, S. Hojyo, H. Horiuchi, S. Furusawa and H. Matsuda, Dev. Comp. Immunol., 30(4), 419-429 (2006)

9.Identification of proteins present in the archaeron Thermoplasma volcanium cultured in aerobic or anaerobic conditions. T. Kawashima, K. Yokoyama, S. Higuchi and M. Suzuki, Proc. Jpn. Acad. Ser.B, 81(6), 204-219(2005)

10.Characterization and expression analysis of a chicken interleukin-6 receptor alpha. N. Nishimichi, T. Kawashima, S. Hojyo, H. Horiuchi, S. Furusawa and H. Matsuda, Dev. Comp. Immunol., 30(4), 419-429 (2005)

11.Biological activity of recombinant chicken interleukin-6 in chicken hybridoma cells.N. Nishimichi, M. Aosasa, T. Kawashima, H. Horiuchi, S. Furusawa and H. Matsuda,Vet. Immunol. Immunopathol., 15(106), 97- 105 (2005)

12.Generation of A Mouse Monoclonal Antibody Against Chicken Interleukin-6, N. Nishimichi, M. Aosasa, T. Kawashima, H. Horiuchi, S. Furusawa and H. Matsuda, Hybridoma, 24(2), 115-117 (2005)

13.Characterization and expression analysis of the chicken interleukin-11 receptor alpha chain, T. Kawashima, S. Hojyo, N. Nishimichi, M. Sato, M. Aosasa, H. Horiuchi, S. Furusawa and H. Matsuda, Dev. Comp. Immunol., 29(4), 349-359 (2005)

14.Nucleotide sequences of the mouse globin beta gene cDNA in a wild derived new haplotype Hbbw1. Ueda, Y., Miyashita N., Imai, K., Yamaguchi, Y, Takamura, K., Notohara, M., Shiroishi, T., Kawashima, T., Ning, L., Wang, C., Wu, X. and Moriwaki, K, Mammal. Genome. 10. 879-882 (1999)

著書及び総説

【総説】
Transcription regulation by feast/famine regulatory proteins, FFRPs, in archaea and bacteria, T. Kawashima, H. Aramaki, T. Oyamada, K. Makino, M. Yamada, H. Okamura, K. Yokoyama, S. A. Ishijima, and M. Suzuki, Biol. Pharm. Bull, 31, 173-186 (2008)

【著書】
川嶋剛(共著)、荒牧弘範、大戸茂弘(編)
コンパス分子生物学 改訂第2版-創薬・テーラーメイド医療に向けて-、南江堂 (2015)

入試情報 ADMISSION