教員紹介

香川 聡子
Tanaka-Kagawa Toshiko

所属・肩書

健康薬学科/環境科学研究室(教授)

最終学歴

北里大学大学院 薬学研究科 博士課程中退

取得学位

博士(薬学、北里大学)

所属学会

日本薬学会、日本毒性学会、室内環境学会

現在の専門分野

環境科学、毒性学

現在の研究課題

●室内環境化学物質の曝露評価に関する研究
●環境化学物質の気道刺激性に関する研究
●環境化学物質に対する感受性個体差に関する研究

主要研究業績

●内環境化学物質によるTRPイオンチャネルの活性化
●室内空気およびハウスダストを介する揮発性/準揮発性有機化合物の曝露評価
●グルタチオンS-転移酵素GSTO1-1の一塩基多型に起因する機能変化
●ヒ素化合物によるMAPキナーゼの活性化
●水銀化合物の体内動態及び毒性発現に影響する生体内因子の役割

最近の研究業績

1.Takeuchi S, Kojima H, Saito I, Jin K, Kobayashi S, Tanaka-Kagawa T, Jinno H, Determination of 34 plasticizers and 25 flame retardants in indoor air from houses in Sapporo, Japan. Sci Total Environ, 491-492:28-33, 2014.

2.Iwasawa K, Tanaka G, Aoyama T, Chowdhury M M, Komori K, Tanaka-Kagawa T, Jinno H, Sakai Y, Prediction of phthalate permeation through pulmonary alveoli using a cultured A549 cell-based in vitro alveolus model and a numerical simulation. AATEX, 18:19-31, 2013.

3.Kokawa Y, Kishi N, Jinno H, Tanaka-Kagawa T, Narimatsu S, Hanioka N, Effect of UDP-glucuronosyltransferase 1A8 polymorphism on raloxifene glucuronidation. Eur J Pharm Sci. 49(2):199-205, 2013.

4.Miyake Y, Mayumi K, Jinno H, Tanaka-Kagawa T, Narimatsu S, Hanioka N, DNA cloning and functional analysis of minipig uridine diphosphate-glucuronosyltransferase 1A1. Biol Pharm Bull. 36(3):452-461, 2013.

5.Hanioka N, Takahara Y, Takahara Y, Tanaka-Kagawa T, Jinno H, Narimatsu S, Hydrolysis of di-n-butyl phthalate, butylbenzyl phthalate and di(2-ethylhexyl) phthalate in human liver microsomes. Chemosphere 89(9):1112-1117, 2012.

6.Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Jinno H, Methylglyoxal activates the human transient receptor potential ankyrin 1 channel. J Toxicol Sci. 37(4): 831-835, 2012.

7.Hirose R, Miura T, Sha R, Shinkai Y, Tanaka-Kagawa T, Kumagai Y,A method for detecting covalent modification of sensor proteins associated with 1,4-naphthoquinone-induced activation of electrophilic signal transduction pathways. J Toxicol Sci. 37(5):891-898, 2012.

8.Takayama N, Iwamoto N, Sumi D, Shinkai Y, Tanaka-Kagawa T, Jinno H, Kumagai Y, Peroxiredoxin 6 is a molecular target for 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells. J Toxicol Sci. 36(6): 817-821, 2011.

9.香川(田中)聡子,古田 光子,柴辻 正喜,神野 透人,西村 哲治, 大型家具からの揮発性有機化合物の放散に関する研究. 国立医薬品食品衛生研究所報告 129: 76-85(Note), 2011.

10.神野 透人,香川(田中)聡子,古田 光子,柴辻 正喜,西村 哲治, 木製大型家具からの揮発性有機化合物の放散に関する研究 -フラックス発生量測定法による放散速度予測-. 国立医薬品食品衛生研究所報告 129: 86-92, 2011.

11.Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y, Initial response and cellular protection through the Keap1/Nrf2 system during the exposure of primary mouse hepatocytes to 1,2-naphthoquinone. Chem Res Toxicol. 24(4):559-566, 2011.

12.香川(田中)聡子,神野 透人,古川 容子,西村 哲治, 家具及び家電製品からの揮発性有機化合物の放散に関する研究. 国立医薬品食品衛生研究所報告 128: 71-77(Note), 2010.

13.Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Nishimura T, Jinno H, Development of a SYBR Green real-time polymerase chain reaction assay for quantitative detection of human N-methyl-D-aspartate receptors subtype 1 splice variants. J Health Sci. 56(5): 527-533, 2010.

14.Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Nishimura T, Jinno H, Activation of the human transient receptor potential vanilloid subtype 1 by essential oils. Biol Pharm Bull. 33(8): 1434-1437, 2010.

15.Hanioka N, Tanabe N, Jinno H, Tanaka-Kagawa T, Nagaoka K, Naito S, Koeda A, Narimatsu S, Functional characterization of human and cynomolgus monkey UDP-glucuronosyl transferase 1A1 enzymes. Life Sci. 87(7-8): 261-268, 2010.

16.Hanioka N, Yamamoto M, Tanaka-Kagawa T, Jinno H, Narimatsu S, Functional characterization of human cytochrome P4502E1 allelic variants: in vitro metabolism of benzene and toluene by recombinant enzymes expressed in yeast cells. Arch Toxicol. 84(5): 363-371, 2010.

17.香川(田中)聡子,神野 透人,小濱 とも子,西村 哲治,徳永 裕司, ハンドスプレー式家庭用品から放散する揮発性有機化合物に関する研究. 国立医薬品食品衛生研究所報告 126: 88-92, 2008.

18.Hanioka N, Takeda Y, Tanaka-Kagawa T, Hayashi K, Jinno H, Narimatsu S, Interaction of bisphenol A with human UDP-glucuronosyltransferase 1A6 enzyme. Environ Toxicol. 23(3): 407-412, 2008.

19.香川(田中)聡子, 神野 透人,小濱 とも子, 宮川 真琴, 吉川 淳, 小松 一裕, 徳永 裕司, スモールチャンバー試験法による家庭用品から放散する揮発性有機化合物の評価. 国立医薬品食品衛生研究所報告 125:79-85, 2007.

20.神野 透人, 香川(田中)聡子, 小濱 とも子, 宮川 真琴, 吉川 淳, 小松 一裕, 徳永 裕司, 室内空気中の総揮発性有機化合物(TVOC) に対する芳香剤・消臭剤の影響に関する研究. 国立医薬品食品衛生研究所報告 125: 72-78, 2007.

21.Hanioka N, Yamamoto M, Iwabu H, Jinno H, Tanaka-Kagawa T, Naito S, Shimizu T, Masuda K, Katsu T, Narimatsu S, Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes. Life Sci. 81(19-20): 1436-1445, 2007.

22.Kim SR, Sai K, Tanaka-Kagawa T, Jinno H, Ozawa S, Kaniwa N, Saito Y, Akasawa A, Matsumoto K, Saito H, Kamatani N, Shirao K, Yamamoto N, Yoshida T, Minami H, Ohtsu A, Saijo N, Sawada J, Haplotypes and a novel defective allele of CES2 found in a Japanese population. Drug Metab Dispos. 35(10): 1865-1872, 2007.

23.Hanioka N, Takeda Y, Jinno H, Tanaka-Kagawa T, Naito S, Koeda A, Shimizu T, Nomura M, Narimatsu S, Functional characterization of human and cynomolgus monkey UDP-glucuronosyl transferase 1A6 enzymes. Chem Biol Interact. 164(1-2): 136-145. 2006.

24.Hanioka N, Obika N, Nishimura M, Jinno H, Tanaka-Kagawa T, Saito K, Kiryu K, Naito S, Narimatsu S, Inducibility of UDP-glucuronosyl transferase 1As by beta-naphthoflavone in HepG2 cells. Food Chem Toxicol. 44(8): 1251-1260, 2006.

25.Tanaka-Kagawa T, Uchiyama S, Matsushima E, Sasaki A, Kobayashi H, Kobayashi H, Yagi M, Tsuno M, Arao M, Ikemoto K, Yamasaki M, Nakashima A, Shimizu Y, Otsubo Y, Ando M, Jinno H, Tokunaga H, Survey of volatile organic compounds found in indoor and outdoor air samples from Japan. 国立医薬品食品衛生研究所報告 123: 27-31, 2005.

26.Saito Y, Hanioka N, Maekawa K, Isobe T, Tsuneto Y, Nakamura R, Soyama A, Ozawa S, Tanaka-Kagawa T, Jinno H, Narimatsu S, Sawada J, Functional analysis of three CYP1A2 variants found in a Japanese population. Drug Metab Dispos. 33(12): 1905-1910, 2005.

27.Jinno H, Hanioka N, Tanaka-Kagawa T, Saito Y, Ozawa S, Sawada J, Transfection assays with allele-specific constructs: functional analysis of UDP-glucuronosyltransferase variants. Methods Mol Biol. 311: 19-29, 2005.

28.Hichiya H, Tanaka-Kagawa T, Soyama A, Jinno H, Koyano S, Katori N, Matsushima E, Uchiyama S, Tokunaga H, Kimura H, Minami N, Katoh M, Sugai K, Goto Y, Tamura T, Yamamoto N, Ohe Y, Kunitoh H, Nokihara H, Yoshida T, Minami H, Saijo N, Ando M, Ozawa S, Saito Y, Sawada J, Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population. Drug Metab Dispos. 33(5): 630-636, 2005.

29.Tsuchiya T, Tanaka-Kagawa T, Jinno H, Tokunaga H, Sakimoto K, Ando M, Umeda M, Inorganic arsenic compounds and methylated metabolites induce morphological transformation in two-stage BALB/c 3T3 cell assay and inhibit metabolic cooperation in V79 cell assay. Toxicol Sci. 84(2): 344-351, 2005.

30.Kaniwa N, Kurose K, Jinno H, Tanaka-Kagawa T, Saito Y, Saeki M, Sawada J, Tohkin M, Hasegawa R, Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686 C> T (P229L) found in an African-American. Drug Metab Dispos. 33(3): 458-465, 2005.

31.Saeki M, Saito Y, Jinno H, Tanaka-Kagawa T, Ohno A, Ozawa S, Ueno K, Kamakura S, Kamatani N, Komamura K, Kitakaze M, Sawada J, Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. Drug Metab Dispos. 32(9): 1048-1054, 2004.

32.Jinno H, Tanaka-Kagawa T, Hanioka N, Ishida S, Saeki M, Soyama A, Itoda M, Nishimura T, Saito Y, Ozawa S, Ando M, Sawada J, Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver. Mol Pharmacol. 65(3): 496-502, 2004.

33.Tanaka-Kagawa T, Hanioka N, Yoshida H, Jinno H, Ando M, Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes. Br J Dermatol. 149(6): 1116-1127, 2003.

34.Hanioka N, Tanaka-Kagawa T, Miyata Y, Matsushima E, Makino Y, Ohno A, Yoda R, Jinno H, Ando M, Functional characterization of three human cytochrome p450 2E1 variants with amino acid substitutions. Xenobiotica. 33(6): 575-586, 2003.

35.Jinno H, Saeki M, Saito Y, Tanaka-Kagawa T, Hanioka N, Sai K, Kaniwa N, Ando M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Ozawa S, Sawada J, Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. J Pharmacol Exp Ther. 306(2): 688-693, 2003.

36.Jinno H, Saeki M, Tanaka-Kagawa T, Hanioka N, Saito Y, Ozawa S, Ando M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Sawada J, Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10. Drug Metab Dispos. 31(5): 528-532, 2003.

37.Jinno H, Tanaka-Kagawa T, Ohno A, Makino Y, Matsushima E, Hanioka N, Ando M, Functional characterization of cytochrome P450 2B6 allelic variants. Drug Metab Dispos. 31(4): 398-403, 2003.

38.Tanaka-Kagawa T, Jinno H, Hasegawa T, Makino Y, Seko Y, Hanioka N, Ando M, Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn). Biochem Biophys Res Commun. 301(2): 516-520, 2003.

39.Jinno H, Tanaka-Kagawa T, Hanioka N, Saeki M, Ishida S, Nishimura T, Ando M, Saito Y, Ozawa S, Sawada J, Glucuronidation of 7-ethyl-10-hydroxy camptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D. Drug Metab Dispos. 31(1): 108-113, 2003.

40.Ishida S, Jinno H, Tanaka-Kagawa T, Ando M, Ohno Y, Ozawa S, Sawada J, Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone. Biochem Biophys Res Commun. 296(1): 172-177, 2002.

41.Hanioka N, Ozawa S, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M, Sawada J, Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes. Drug Metab Dispos. 30(4): 391-396, 2002.

42.Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M, Determination of UDP-glucuronosyltransferase UGT1A6 activity in human and rat liver microsomes by HPLC with UV detection. J Pharm Biomed Anal. 25(1): 65-75, 2001.

43.Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M, Interaction of bisphenol A with rat hepatic cytochrome P450 enzymes. Chemosphere. 41(7): 973-978, 2000.

44.Hanioka N, Tanaka-Kagawa T, Chung YS, Nishimura T, Jinno H, Ando M, Changes in hepatic cytochrome P450 enzymes by biodegradation products of 4-tert-octylphenol polyethoxylate in rats. Bull Environ Contam Toxicol. 64(6): 804-810, 2000.

45.Hanioka N, Jinno H, Chung YS, Nishimura T, Tanaka-Kagawa T, Ando M, Effect of 4-tert-octylphenol on cytochrome P450 enzymes in rat liver. Arch Toxicol. 73(12): 625-631, 2000.

受賞

●International Symposium on Bio-Trace Elements; BITREL2002 最優秀ポスター賞
●平成20年度 室内環境学会年会・ポスター賞
●平成21年度 室内環境学会年会・ポスター賞
●平成25年度 室内環境学会年会・ポスター賞
●日本毒性学会 平成25年度田邊賞 (年間最優秀論文賞)

著書及び総説

1.香川(田中)聡子(共同執筆):環境試験法:空気試験法,衛生試験法・注解2015(日本薬学会編),金原出版,2015年.

2.香川(田中)聡子(共同執筆):法規・基準値等の一覧,衛生試験法・注解2015(日本薬学会編),金原出版,2015年.

3.香川(田中)聡子(共同執筆):室内環境,スタンダード薬学シリーズ5 健康と環境(第2版)(日本薬学会編),東京化学同人,2012.

4.Jinno H, Hanioka N, Tanaka-Kagawa T, Saito Y, Ozawa S, Sawada J. :PART II-2, Transfection assays with allele-specific constructs: functional analysis of UDP-glucuronosyltransferase variants. Methods in Molecular Biology 311: Pharmacogenomics, Humana Press, 2005.

入試情報 ADMISSION