教員紹介

河村 伊久雄
Kawamura Ikuo

所属・肩書

健康薬学科/環境科学研究室(教授)

最終学歴

九州大学大学院 医学系研究科 博士課程単位取得退学

取得学位

医学博士

所属学会

なし

現在の専門分野

感染免疫学・細菌学

現在の研究課題

細胞内寄生菌に対する感染防御誘導機序の解明

主要研究業績

●リステリアに対する感染防御の誘導における病原因子リステリオリシンOとAIM2の役割に関する研究
●Mycobacterium bovis BCG免疫で誘導される感染防御におけるPD-1分子の役割に関する研究
●ASCスペックを介したカスパーゼ1活性化機序に関する研究

最近の研究業績

1. Fang R. Uchiyama R. Sakai S. Hara H. Tsutsui H. Suda T. Mitsuyama M. Kawamura I. and Tsuchiya K., 2019, ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism, Mucosal Immunol., 12: 1092-1103.

2. Tanaka-Kagawa T. Saito I. Onuki A. Tahara M. Kawakami T. Sakai S. Ikarashi Y. Oizumi S. Chiba M. Uemura H. Miura N. Kawamura I. Hanioka N. and Jinno H., 2019, Method validation for the determination of phthalates in indoor air by GC-MS with solid-phase adsorption/solvent extraction using octadecyl silica filter and styrene-divinylbenzene copolymer cartridge, BPB Reports, 2:86-90.

3. Tsuchiya K. Hara H. Fang R. Hernandez-Cuellar E. Sakai S. Daim S. Chen X. Dewamitta S.R. Qu H. Mitsuyama M. and Kawamura I., 2014, The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL-18 production in an inflammasome-dependent and –independent manner, Eur. J. Immunol., 44: 3696-3707.

4. Fang R. Hara H. Sakai S. Hernandez-Cuellar E. Mitsuyama M. Kawamura I. and Tsuchiya K., 2014, Type I interferon signaling regulates activation of the absent in melanoma 2 inflammasome during Streptococcus pneumoniae infection, Infect. Immun., 82: 2310-2317.

5. Yang R. Xi C. Dewamitta R. S. Sakai, S. Tsuchiya K. Hara H. Shen Y. Qu H. Fang R. Mitsuyama M. and Kawamura I., 2014, The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation, Pathog. Dis., 70: 51-60.

6. Hara H. Tsuchiya K. Kawamura I. Fang R. Hernandez-Cuellar E. Shen Y. Mizuguchi J. Schweighoffer E. Tybulewicz V. and Mitsuyama M., 2013, Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity, Nat. Immunol., 14: 1247-1255.

7. Yokobori N. Lopez B. Geffner L. Sabio y Garcia C. Schierloh P. Barrera L. de la Barrera S. Sakai S. Kawamura I. and Mitsuyama M. Ritacco V. and del Carmen Sasiain M., 2013, Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models, Infect. Genet. Evol., 16: 151-156.

8. Hernandez-Cuellar E. Tsuchiya K. Hara H. Fang R. Sakai S. Kawamura I. Akira S. and Mitsuyama M., 2012, Nitric oxide inhibits the NLRP3 inflammasome, J. Immunol., 189: 5113-5117.

9. Yamamoto T. Hara H. Tsuchiya K. Sakai S. Fang R. Matsuura M. Nomura T, Sato F. Mitsuyama M. and Kawamura I., 2012, Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability, Infect. Immun., 80: 2323-2332.

10. Endo Y. Takahashi M. Iwaki D. Ishida Y. Nakazawa N. Kodama T. Matsuzaka T. Knno K. Liu Y. Tsuchiya K. Kawamura I. Ikawa M. Waguri S. Wada I. Matsushita M. Schwaeble W. J. and Fujita T., 2012, Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection, J. Immunol., 189: 5860-5866.

11. Fang R. Tsuchiya K. Kawamura I. Shen Y. Hara H. Sakai S. Yamamoto T. Fernandes-Alnemri T. Yang R. Hernandez-Cuellar E. Dewamitta S. R. Xu Y. Qu H. Alnemri E. S. and Mitsuyama M., 2011, Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection, J. Immunol., 187: 4890-4899.

12. Daim S. Kawamura I. Tsuchiya K. Hara H. Kurenuma T. Shen Y. Dewamitta S. R. Sakai S. Nomura T. Qu H. and Mitsuyama M., 2011, Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages, J. Med. Microbiol., 60: 582-591.

13. Sakai S. Kawamura I. Okazaki T. Tsuchiya K. Uchiyama R. and Mitsuyama M., 2010, PD-1-PD-L1 pathway impairs Th1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guerin, Int. Immunol., 22: 915-925.

14. Tsuchiya K. Hara H. Kawamura I. Nomura T. Yamamoto T. Daim S. Dewamitta S. R. Shen Y. Fang R. and Mitsuyama M., 2010, Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes, J. Immunol., 185: 1186-1195.

15. Shen Y. Kawamura I. Nomura T. Tsuchiya K. Hara H. Dewamitta S. R. Sakai S. Qu H. Daim S. Yamamoto T. and Mitsuyama M., 2010, Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages, Infect. Immun., 78: 2857-2867.

16. Emoto M. Yoshida T. Fukuda T. Kawamura I. Mitsuyama M. Kita E. Hurwits R. Kaufmann S. H. E. and Emoto Y., 2010, α-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation, Infect. Immun., 78: 2667-2676.

17. Dewamitta S. R. Nomura T. Kawamura I. Hara H. Tsuchiya K. Kurenuma T. Shen Y. Daim S. Yamamoto T. Qu H. Sakai S. and Mitsuyama M., 2010, Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes, Infect. Immun., 78: 1884-1894.

18. Kurenuma T. Kawamura I. Hara H. Uchiyama R. Daim S. Dewamitta S. R. Sakai S. Tsuchiya K. Nomura T. and Mitsuyama M., 2009, The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages, Infect. Immun., 77: 3992-4001.

19. Hara H. Tsuchiya K. Nomura T. Kawamura I. Shoma S. and Mitsuyama M., 2008, Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm, J. Immunol., 180: 7859-7868.

20. Shoma S. Tsuchiya K. Kawamura I. Nomura T. Hara H. Uchiyama R. Daim S. and Mitsuyama M., 2008, Critical involvement of pneumolysin in production of IL-1α and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation, Infect. Immun., 76: 1547-1557.

21. Tsutsui N. Gejyo F. Kawamura I. and Mitsuyama M., 2008, Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases, Acta Medica et biologica, 56: 63-71.

22. Kaku T. Kawamura I. Uchiyama R. Kurenuma T. and Mitsuyama M., 2007, RD1 region in mycobacterial genome is involved in the induction of necrosis in infected RAW264 cells via mitochondrial membrane damage and ATP depletion, FEMS Microbiol. Lett., 274: 189-195.

23. Nomura T. Kawamura I. Kohda C. Baba H. Ito Y. Kimoto T. Watanabe I. and Mitsuyama M., 2007, Irreversible loss of membrane-binding activity of Listeria-derived cytolysins in non-acidic conditions: a distinct difference from allied cytolysins produced by other Gram-positive bacteria, Microbiology, 153: 2250-2258.

24. Hara H. Kawamura I. Nomura T. Tominaga T. Tsuchiya K. and Mitsuyama M., 2007, Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 immune response against Listeria monocytogenes infection: distinct role of listeriolysin O determined by cytolysin gene replacement, Infect. Immun., 75: 3791-3801.

25. Uchiyama R. Kawamura I. Fujimura T. Kawanishi M. Tsuchiya K. Tominaga T. Kaku T. Fukasawa Y. Sakai S. Nomura T. and Mitsuyama M., 2007, Involvement of caspase-9 in the inhibition of necrosis of RAW 264 cells infected with Mycobacterium tuberculosis, Infect. Immun., 75: 2894-2902.

26. Kohwiwattanagun J. Kawamura I. Fujimura T. and Mitsuyama M., 2007, Mycobacterial mammalian cell entry protein 1A (Mce1A)-mediated adherence enhances the chemokine production by A549 alveolar epithelial cells, Microbiol. Immunol., 51: 253-261.

27. Yamamoto K. Kawamura I. Ito J. and Mitsuyama M., 2006, Modification of allergic inflammation in murine model of rhinitis by different bacterial ligands: involvement of mast cells and dendritic cells, Clin. Exp. Allergy, 36: 760-769.

28. Yamamoto K. Kawamura I. Tominaga T. Nomura T. Ito J. and Mitsuyama M., 2006, Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice, Clin. Exp. Immunol., 144, 475-484.

29. Watanabe I. Nomura T. Tominaga T. Yamamoto K. Kohda C. Kawamura I. and Mitsuyama M., 2006, Dependence of the lethal effect of pore-forming haemolysins of Gram-positive bacteria on cytolytic activity, J. Med. Microbiol., 55: 505-510.

30. Nakamura K. Miyagi K. Koguchi Y. Kinjo Y. Uezu K. Kinjo T. Akamine M. Fujita J. Kawamura I. Mitsuyama M. Adachi Y. Ohno N. Takeda K. Akira S. Miyazato A. Kaku M. and Kawakami K., 2006, Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans, FEMS Immunol. Med. Microbiol., 47: 148-154.

31. Ito Y. Kawamura I. Kohda C. Tsuchiya K. Nomura T. and Mitsuyama M., 2005, Seeligeriolysin O, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via Toll-like receptors in a profile different from that induced by other bacterial ligands, Int. Immunol., 17: 1597-1606.

32. Yamamoto K. Kawamura I. Tominaga T. Nomura T. Kohda C. Ito J. and Mitsuyama M., 2005, Listeriolysin O, a cytolysin derived from Listeria monocytogenes, inhibits generation of ovalbumin-specific Th2 immune response by skewing maturation of antigen-specific T cells into Th1 cells, Clin. Exp. Immunol. 142: 268-274.

33. Fukasawa Y. Kawamura I. Uchiyama R. Yamamoto K. Kaku T. Tominaga T. Nomura T. Ichiyama S. Ezaka T. and Mitsuyama M., 2005, Streptomycin-dependent exhibition of cytokine-inducing activity in streptomycin-dependent Mycobacterium tuberculosis 18b, Infect. Immun., 73: 7051-7055.

34. Makino M. Kawai M. Kawamura I. Fujita M. Gejo F. and Mitsuyama M., 2005, Involvement of reactive oxygen intermediate in the enhanced expression of virulence-associated genes of Listeria monocytogenes inside activated macrophages, Microbiol. Immunol., 49: 805-811.

35. Takeuchi O. Suzuki T. Kawamura I. Kobayashi N. Takizawa-Hashimoto A. and Mitsuyama M., 2005, Involvement of the virulence gene products of Yersinia enterocolitica in the immune response of infected mice, FEMS Immunol. Med. Microbiol., 45: 321-329.

36. Tsuchiya K. Kawamura I. Takahashi A. Nomura T. Kohda C. and Mitsuyama M., 2005, Listeriolysin O-induced membrane permeation mediates persistent interleukin-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro, Infect. Immun., 73: 3869-3877.

37. Mochizuki H. Nomura T. Kawamura I. and Mitsuyama M., 2005, Enhanced resistance to Gram-positive bacterium and increased susceptibility to bacterial endotoxin in mice sensitized with Propionibacterium acnes: involvement of Toll-like receptor, FEMS Immunol. Med. Microbiol., 43: 287-293.

38. Chang B. Amemura-Maekawa J. Kura F. Kawamura I. and Watanabe H., 2004, Expression of IL-6 and TNF- in human alveolar epithelial cells is induced by invading, but not by adhering, Legionella pneumophila, Microb. Pathog. 37: 295-302.

39. Kimoto T. Kawamura I. Kohda C. Nomura T. Tsuchiya K. Ito Y. Watanabe I. Kaku T. Setianingrum E. and Mitsuyama M., 2003, Differences in gamma interferon production induced by listeriolysin O and ivanolysin O result in different levels of protective immunity in mice infected with Listeria monocytogenes and Listeria ivanovii, Infect. Immun., 71: 2447-2454.

40. Ito Y. Kawamura I. Kohda C. Baba H. Nomura T. Kimoto T. Watanabe I. and Mitsuyama M., 2003, Seeligeriolysin O, a cholesterol-dependent cytolysin of Listeria seeligeri, induces gamma interferon from spleen cells of mice, Infect. Immun., 71: 234-241.

41. Kohda C. Kawamura I. Baba H. Nomura T. Ito Y. Kimoto T. Watanabe I. and Mitsuyama M., 2002, Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin O from Listeria monocytogenes, Infect. Immun., 70: 1334-1341.

42. Nomura T. Kawamura I. Tsuchiya K. Kohda C. Baba H. Ito Y. Kimoto T. Watanabe I. and Mitsuyama M., 2002, Essential role of interleukin-12 (IL-12) and IL-18 for gamma interferon production induced by listeriolysin O in mouse spleen cells, Infect. Immun., 70: 1049-1055.

43. Baba H. Kawamura I. Kohda C. Nomura T. Ito Y. Kimoto T. Watanabe I. Ichiyama I. and Mitsuyama M., 2002, Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity, Infect. Immun., 70: 107-113.

44. Ito Y. Kawamura I. Kohda C. Baba H. Kimoto T. Watanabe I. Nomura T. and Mitsuyama M., 2001, Difference in cholesterol-binding and cytolytic activities between listeriolysin O and seeligeriolysin O: a possible role of alanine residue in tryptophan-rich undecapeptide, FEMS Microbiol. Lett., 203, 185-189.

45. Chitale S. Ehrt S. Kawamura I. Fujimura T. Shimono N. Anand N. Lu S. Cohen-Gould L. and Riley L. W., 2001, Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry, Cell. Microbiol., 3: 247-254.

46. Baba H. Kawamura I. Kohda C. Nomura T. Ito Y. Kimoto T. Watanabe I. Ichiyama S. and Mitsuyama M., 2001, Essential role of domain 4 of pneumolysin from Streptococcus pneumoniae in cytolytic activity as determined by truncated proteins, Biochem. Biophy. Res. Co., 281: 37-44.

47. Yang J. Kawamura I. and Mitsuyama M., 1997, Requirement of the initial production of gamma interferon in the generation of protective immunity of mice against Listeria monocytogenes, Infect. Immun., 65: 72-77.

48. Yang J. Kawamura I. and Mitsuyama M., 1997, Involvement of inflammatory cytokines and nitric oxide in the expression of non-specific resistance to Listeria monocytogenes in mice induced by viable but not killed Mycobacterium bovis BCG, Microb. Pathog., 22: 79-88.

49. Xiong H. Kawamura I. Nishibori T. and Mitsuyama M., 1996, Suppression of IFN-γ production from Listeria monocytogenes-specific T cells by endogenously produced nitric oxide, Cell. Immunol., 172: 118-125.

50. Nishibori T. Xiong H. Kawamura I. Arakawa M. and Mitsuyama M., 1996, Induction of cytokine gene expression by listeriolysin O and roles of macrophages and NK cells, Infect. Immun., 64: 3188-3195.

51. Yang J. Kawamura I. Zhu H. and Mitsuyama M., 1995, Involvement of natural killer cells in nitric oxide production by spleen cells after stimulation with Mycobacterium bovis BCG. Study of the mechanism of the different abilities of viable and killed BCG, J. Immunol., 155: 5728-5735.

52. Fujio H. Kawamura I. Miyamoto H. Mitsuyama M. and Yoshida S., 1995, Decreased capacity of aged mice to produce interferon-gamma in Legionella pneumophila infection, Mech. Aging Dev., 81: 97-106.

53. Nishibori T. Cooray K. Xiong H. Kawamura I. Fujita M. and Mitsuyama M., 1995, Correlation between the presence of virulence-associated genes as determined by PCR and actual virulence to mice in various strains of Listeria spp, Microbiol. Immunol. 39: 343-349.

54. Kawamura I. Yang J. Takaesu Y. Fujita M. Nomoto K. and Mitsuyama M., 1994, Antigen provoking gamma interferon production in response to Mycobacterium bovis BCG and functional difference in T-cell responses to this antigen between viable and killed BCG-immunized mice, Infect. Immun., 62: 4396-4403.

55. Yasumoto S. Moroi Y. Koga Y. Kawamura I. Mitsuyama M. and Hori Y., 1994, Ultraviolet-B irradiation alters cytokine production by immune lymphocytes in herpes simplex virus-infected mice, J. Dermatol. Sci., 8: 218-223.

56. Xiong H. Kawamura I. Nishibori T. and Mitsuyama M., 1994, Cytokine gene expression in mice at an early stage of infection with various strains of Listeria spp. differing in virulence, Infect. Immun., 62: 3649-3654.

57. Oshikiri K. Kawamura I. Hara K. and Mitsuyama M., 1994, Specific immune response to the 40-kDa outer-membrane protein of Porphyromonas gingivalis in mice, Arch. Oral Biol., 39: 707-713.

58. Yoshikawa H. Kawamura I. Fujita M. Tsukada H. Arakawa M. and Mitsuyama M., 1993, Membrane damage and interleukin-1 production in murine macrophages exposed to listeriolysin O, Infect. Immun., 61: 1334-1339.

59. Kawamura I. Tsukada H. Yoshikawa H. Fujita M. Nomoto K. and Mitsuyama M., 1992, IFN-γ-producing ability as a possible marker for the protective T cells against Mycobacterium bovis BCG in mice, J. Immunol., 148: 2887-2893.

60. Tsukada H. Kawamura I. Fujimura T. Igarashi K. Arakawa M. and Mitsuyama M., 1992, Induction of macrophage interleukin-1 production by Listeria monocytogenes hemolysin, Cell. Immunol., 140: 21-30.

61. Tsukada H. Kawamura I. Arakawa M. Nomoto K. and Mitsuyama M., 1991, Dissociated development of T cells mediating delayed-type hypersensitivity and protective T cells against Listeria monocytogenes and their functional difference in lymphokine production, Infect. Immun., 59, 3589-3595.

62. Goto K. Mitsuyama M. Imaizumi S. Kawamura I. and Yano I., 1991, Mycolic acid-containing glycolipid as a possible virulence factor of Rhodococcus equi for mice, Microbiol. Immunol., 35: 175-185.

63. Mitsuyama M. Igarashi K. Kawamura I. Ohmori T. and Nomoto K., 1990, Difference in the induction of macrophage interleukin-1 production between viable and killed cells of Listeria monocytogenes, Infect. Immun., 58: 1254-1260.

64. Kawamura I. Mitsuyama M. and Nomoto K., 1990, Enhanced protection of cyclophosphamide-treated mice against infection with Psedomonas aeruginosa after treatment with Z-100, a polysaccharide-rich extract from Mycobacterium tuberculosis Aoyama B, Immunopharm. Immunot., 12: 331-343.

65. Asensi V. Himeno K. Kawamura I. Sakumoto M. and Nomoto K., 1990, In vivo treatment with anti B-220 monoclonal antibody affects T and B cell differentiation, Clin. Exp. Immunol. 80: 268-273.

66. Kawamura I. Himeno K. Sakumoto M. Eto M. and Nomoto K., 1989, Early development of two helper T cell subsets for delayed hypersensitivity after bone marrow transplantation, Biomedical Res., 10: 239-246.

67. Miura S. Kawamura I. Yamada A. Kawakita T. Kumazawa Y. Himeno K. and Nomoto K., 1989, Effect of a traditional chinese herbal medicine, REN-SHEN-YANG-RONG-TANG (Japanese name: Ninjin-youei-to) on hematopoietic stem cells in mice, Int. J. Immunopharmacol., 11: 771-780.

68. Assensi V. Himeno K. Kawamura I. Sakumoto M. and Nomoto K., 1989, In vivo influence of the anti-B220 monoclonal antibody administration of the T cell differentiation in mice, Microbiol. Immunol., 33: 329-339.

69. Asensi V. Himeno K. Kawamura I. Sakumoto M. and Nomoto K., 1989, Treatment of autoimmune MRL/lpr mice with anti-B220 monoclonal antibody reduces the level of anti-DNA antibodies and lymphadenopathies, Immunology 68: 204-208.

70. Kawamura I. Koga Y. Oh-Hori N. Onodera K. Kimura G. and Nomoto K., 1989, Depletion of the surface CD4 molecule by the envelope protein of human immunodeficiency virus expressed in a human CD4+ monocytoid cell line. J. Virol., 63: 3748-3754.

71. Hussain A. Himeno K. Mayumi H. Kawamura I. Tsuru S. and Nomoto K., 1989, Immunomodulatory effects of cholera toxin in mice, Natural Immunity and Cell Growth Regulation, 8: 231-244.

72. Nakamura S. Himeno K. Yamada A. Kawamura I. and Nomoto K., 1987, Antigen-specific augmentation factor involved in murine delayed-type footpad reaction. IV. Effect of delayed-type hypersensitivity augmentation factor on in vitro induction of DTH, Cell. Immunol., 105: 54-64.

73. Yamada A. Himeno K. Nakamura S. Kawamura I. and Nomoto K., 1987, Transfer of resistance to primary infection of Listeria monocytogenes and early induction of delayed hypersensitivity by sera from L. monocytogenes-infected mice, Infect. Immun., 55: 3078-3084.

著書及び総説

著書

1. 河村伊久雄、光山正雄.2005.細菌感染の分子応答機構.臨床免疫学 上 ー基礎研究の進歩と最新の臨床ー (分担)日本臨床増刊.日本臨床社.大阪、pp.477-482

2. 河村伊久雄、光山正雄.2003.結核の感染免疫.工藤翔二、土屋了介、金沢実、大田健編.(分担)Annual Review呼吸器.中外医学社.東京、pp.50-59 

3. 光山正雄、河村伊久雄.2002.リステリア感染におけるサイトカイン産生.今西二郎、淀井淳司、湊長博、山本一彦編.(分担)別冊医学のあゆみ 免疫疾患ver.2.医歯薬出版.東京、pp.268-272

4. 光山正雄、河村伊久雄.2002.細胞内寄生細菌感染における防御機構.今西二郎編.(分担)感染症の宿主防御機構 ー理論と実際ー.医薬ジャーナル社.大阪、pp.148-157

5. 河村伊久雄.2001.結核菌のエスケープ機構と宿主免疫応答.光山正雄編.(分担)結核.医薬ジャーナル社.大阪、pp.125-134

6. 河村伊久雄.2000.ELISPOT法によるインターロイキン産生細胞数の測定.田辺和裄、脇誠治、小島荘明、北潔編.(分担)マラリア学ラボマニュアル.菜根出版.東京、pp.151-155

7. 光山正雄、河村伊久雄.1999.感染とサイトカイン.淀井淳司編.(分担)別冊医学のあゆみ 生体応答の新展開 感染症と生体防御/ストレス応答/免疫応答/シグナル伝達とレドックス制御.医歯薬出版.東京、pp.13-18

8. 光山正雄、河村伊久雄.1997.細菌におけるNO(一酸化窒素)産生の機構と役割.日本生体防御学会編.(分担)マクロファージと生体防御 ー新しい研究の展開ー.菜根出版.東京、pp.183-202

9. 河村伊久雄.1996.結核と感染抵抗性.三瀬勝利、寺脇良郎、橋本一編.(分担)再燃する細菌感染症.菜根出版.東京、pp.159-170

10. 光山正雄、河村伊久雄.1992.マクロファージの機能測定 殺菌能.徳永徹、吉田彪、赤川清子編.(分担)マクロファージ実験マニュアル.講談社.東京、pp.158-165


総説

1. 河村伊久雄.2014.特集 呼吸器感染症研究における新しい展開 抗酸菌に対する宿主応答とサイトカインネットワーク.呼吸器内科(科学評論社、東京)26: 42−48

2. 河村伊久雄.2013.特集 結核ー古くて新しい感染症ー 結核に対する感染防御機構.最新医学(最新医学社、大阪)68: 86-91

3. 河村伊久雄、酒井俊祐.2013.結核 ー病態解明と制御の新展開 結核菌に対する免疫応答調節機構ー PD-1を中心に.医学の歩み(医歯薬出版、東京)246: 489-494

4. 河村伊久雄.2010.特集「免疫と結核」 結核に対する感染防御.Kekkaku(結核病学会、東京)85: 539-546

5. 土屋晃介、河村伊久雄、光山正雄.2009.細菌と宿主の相互作用 細胞内寄生菌のマクロファージ内生存戦略.蛋白質 核酸 酵素(共立出版、東京)54: 996-1001

6. 河村伊久雄.2008.第83回総会シンポジウム III. 臨床抗酸菌学の最前線 結核菌の病原性機序 ー細胞内寄生戦略ー.Kekkaku(結核病学会、東京)83: 681-698

7. 河村伊久雄.2008.結核菌のマクロファージ内生存機構.Jpn. J. Leprosy 77: 219-224

8. 河村伊久雄、光山正雄.2007.抗結核防御免疫と結核菌による免疫制御.実験医学(羊土社、東京)25: 105-111 

9. 河村伊久雄.2007.結核菌の病原性発現機構はどこまで判ったか.化学療法の領域(医薬ジャーナル社、大阪)23: 62-68

10. 河村伊久雄、光山正雄.2004.結核の免疫学.医薬ジャーナル(医薬ジャーナル社、大阪)40: 729-734

11. 光山正雄、河村伊久雄、幸田力.2001.リステリアの膜傷害毒素と免疫系の相互作用.蛋白質 核酸 酵素 生物間の攻撃と防御の蛋白質 毒素と生物間相互作用を見直す(内山竹彦、中島暉躬、名取俊二、正木春彦編)(共立出版社、東京)46: 556-561 

12. 河村伊久雄、光山正雄.2001.抗産菌の細胞内感染の分子機構.化学療法の領域 結核と非定型抗酸菌のすべて ー基礎から臨床までー(化学療法研究会編)(医薬ジャーナル社、大阪)17: 22-28

13. 河村伊久雄、光山正雄.2000.IL-12と細胞内寄生体感染.Biotherapy(癌と化学療法社、東京)7: 675-680

14. 河村伊久雄.2000.リステリア膜傷害毒素listeriolysin OによるTh1細胞の誘導.臨床免疫(臨床免疫編集委員会編)(科学評論社、東京)34: 153-160

15. 河村伊久雄、光山正雄.1998.特異的、非特異的感染防御因子.Infection Control(メディカ出版、大阪)7: 902-908

16. 光山正雄、河村伊久雄.1993.細菌感染とサイトカイン.細胞接着分子、Brain Medical(メディカルレビュー社、東京)5: 339-346

17. 光山正雄、河村伊久雄.1993.特異的・非特異的感染防御因子.Mebio コンプロマイズドホストと感染症(メジカルビュー社、東京)10: 10-14

18. 河村伊久雄、光山正雄.1993.抗結核免疫の発現におけるT細胞の機能と役割.最新医学(最新医学社、大阪)48: 1078-1084

19. 河村伊久雄.1992.ELISPOT法によるIFN-γ産生細胞の測定.生体防御(ライフサイエンス社、東京)9: 254-257

20. 野本亀久雄、河村伊久雄.1988.実験動物としてのジャコウネズミ.感染、炎症、免疫(医薬の門社、東京)18: 198-205

入試情報 ADMISSION