教員紹介

SDGsへの取り組み

最終学歴

北里大学大学院薬学研究科修士課程（薬学専攻）修了

取得学位

博士（薬学）（東北大学）

所属学会

日本薬学会、日本毒性学会、米国毒性学会（Society of Toxicology）

現在の専門分野

時間毒性学、環境科学

現在の研究課題

●薬毒物の感受性時刻差
●喘息発作における日内変動と生体内因子
●概日リズムを考慮した健康影響解析

主要研究業績

●カドミウムの感受性時刻差とその機構解析
●概日リズム攪乱が引き起こす精巣機能障害
●メタロチオネインの生理機能解析

最近の研究業績

1. Yoshioka, H., Tominaga, S., Nishikawa, M., Shinohara, Y., Nakao, M., Yoshikawa, M., Maeda, T., Miura, N. (2021), Different Renal Chronotoxicity of Bromobenzene and Its
Intermediate Metabolites in Mice, Biological & pharmaceutical bulletin, 44, 150-153.

2. Numata, M., Hirano, A., Yamamoto, Y., Yasuda, M., Miura, N., Sayama, K., Shibata, M.A., Asai, T., Oku, N., Miyoshi, N., Shimoi, K. (2021), Metastasis of Breast Cancer Promoted by
Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice, J Circadian Rhythms, 19, 2.

3. Yoshioka, H., Tominaga, S., Shinohara, Y., Hwang, G.W., Maeda, T., Miura, N. (2020), Chronotoxicity of Streptomycin-Induced Renal Injury in Mice, Biological & pharmaceutical
bulletin, 43, 53-58.

4. Suzuki, T., Miura, N., Hojo, R., Yanagiba, Y., Suda, M., Hasegawa, T., Miyagawa, M., Wang, R.S. (2020), Genotoxicity assessment of titanium dioxide nanoparticle accumulation of
90 days in the liver of gpt delta transgenic mice, Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 42, 7.

5. Sato, M., Toyama, T., Kim, M.S., Lee, J.Y., Hoshi, T., Miura, N., Naganuma, A., Hwang, G.W. (2020), Increased putrescine levels due to ODC1 overexpression prevents
mitochondrial dysfunction-related apoptosis induced by methylmercury, Life sciences, 256, 118031.

6. Ogushi, S., Ikemoto, S., Miura, N., Nakanishi, T., Kimura, T. (2020), Cadmium Inhibits All-Trans-Retinoic Acid-Induced Increase of Nitroblue Tetrazolium Reduction Activity and
Induces Metallothionein 1G Expression in Human Acute Myelocytic Leukemia HL-60 Cells, Biol Pharm Bull Rep, (in press).

7. Yoshioka, H., Ohishi, R., Hirose, Y., Torii-Goto, A., Park, S.J., Miura, N., Yoshikawa, M. (2019), Chronopharmacology of dapagliflozin-induced antihyperglycemic effects in
C57BL/6J mice, Obesity research & clinical practice, 13, 505-510.

8. Yoshioka, H., Hirose, Y., Ohishi, R., Tominaga, S., Torii-Goto, A., Park, S.J., Miura, N., Yoshikawa, M. (2019), Diurnal Variation of Sitagliptin-Induced Pharmacological Effects in
C57BL/6J Mice, Biological & pharmaceutical bulletin, 42, 1562-1568.

9. Miura, N., Ohtani, K., Hasegawa, T., Yoshioka, H., Hwang, G.W. (2019), Biphasic adverse effect of titanium nanoparticles on testicular function in mice, Scientific reports, 9,
14373.

10. Miura, N., Ohtani, K., Hasegawa, T., Hwang, G., Yoshioka, H. (2019), Impairment of fertilization efficiency in mice following nano-sized titanium exposure, Fund Toxicol Sci, 6,
113-116.

11. Itoh, H., Wang, R.S., Maki, S., Niu, Q., Shang, H., Su, Y., Weng, Z., Saito, H., Miura, N., Takahashi, M. (2019), Effects of work schedule and period of exposure on changes in
urinary chromium and nickel excretion among rotating shift workers in a stainless-steel plant, Chronobiology international, 36, 1439-1446.

12. Yoshioka, H., Nonogaki, T., Shinohara, Y., Suzui, M., Mori, Y., Hwang, G.W., Ohtani, K., Miura, N. (2018), Lethal chronotoxicity induced by seven metal compounds in mice, J
Toxicol Sci, 43, 129-134.

13. Yoshioka, H., Nonogaki, T., Ohnishi, H., Fukuishi, N., Yoshikawa, M., Gui, M.Y., Jin, Y.R., Li, X.W., Adachi, Y., Ohno, N., Takeya, K., Hitotsuyanagi, Y., Miura, N., Aoyagi, Y. (2018),
1O, 20O-diacetyl kamebakaurin protects against acetaminophen-induced hepatotoxicity in mice, Biomedical research (Tokyo, Japan), 39, 251-260.

14. Sato, M., Toyama, T., Lee, J.Y., Miura, N., Naganuma, A., Hwang, G.W. (2018), Activation of ornithine decarboxylase protects against methylmercury toxicity by increasing
putrescine, Toxicol Appl Pharmacol, 356, 120-126.

15. Yoshioka, H., Usuda, H., Miura, N., Fukuishi, N., Nonogaki, T., Onosaka, S. (2017), Vitamin D3-induced hypercalcemia increases carbon tetrachloride-induced hepatotoxicity
through elevated oxidative stress in mice, PLoS One, 12, e0176524.

16. Yoshioka, H., Nonogaki, T., Fukuishi, N., Shinohara, Y., Hwang, G.W., Ohtani, K., Miura, N. (2017), Chronotoxicity of bromobenzene-induced hepatic injury in mice, J Toxicol Sci,
42, 251-258.

17. Yoshioka, H., Aoyagi, Y., Fukuishi, N., Gui, M.Y., Jin, Y.R., Li, X.W., Adachi, Y., Ohno, N., Takeya, K., Hitotsuyanagi, Y., Miura, N., Nonogaki, T. (2017), Suppressive effect of
kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice, Pharmacol Rep, 69, 903-907.

18. Miura, N., Yoshioka, H., Ashimori, A., Ohtani, K., Hasegawa, T., Hwang, G.W., Ikeda, M., Nonogaki, T. (2017), Multidirectional analyses of hepatic chronotoxicity induced by
cadmium in mice, J Toxicol Sci, 42, 597-604.

19. Miura, N., Ohtani, K., Hasegawa, T., Yoshioka, H., Hwang, G. (2017), High sensitivity of testicular function to titanium nanoparticles, J Toxicol Sci, 42, 359-366.

20. Kim, M., Takahashi, T., Lee, J., Miura, N., Asanuma, M., Hwang, G., Naganuma, A. (2017), Identification of transcription factors activated by methylmercury in mouse brain, Fund
Toxicol Sci, 4, 37-39.

21. Fukaya, S., Yoshioka, H., Okano, T., Nagatsu, A., Miura, N., Nonogaki, T., Onosaka, S. (2017), Non-toxic Level of Acetaminophen Potentiates Carbon Tetrachloride-Induced
Hepatotoxicity in Mice, Biological & pharmaceutical bulletin, 40, 1590-1594.

受賞

●日本生化学会　JB論文賞(1997)
●日本薬学会東北支部会奨励賞(2001)
●メタルバイオサイエンス研究会奨励賞(2005)
●日本毒性学会田邊賞(2014)
●日本毒性学会ファイザー賞(2020)