教員紹介

佐藤 康夫
Sato Yasuo

所属・肩書

漢方薬学科/医薬品化学研究室(教授)

最終学歴

東京大学 薬学系大学院 博士課程

取得学位

博士(薬学)

所属学会

日本薬学会、有機合成化学協会、米国化学会、情報計算化学生物学会

現在の専門分野

薬化学、ケミカルバイオロジー

現在の研究課題

●新規な複素環誘導体の合成法と物理化学的性質の調査
●生体機能を調節する化合物の設計と医薬品への適用検討

主要研究業績

●副作用の少ない下痢型IBS治療薬の探索
●経口吸収性に優れた新規ヒスタミンH3受容体アゴニストの創製と中枢作用

最近の研究業績

1.Okuno, Y.; Kitagawa, Y.; Kamiya, S.; Hasegawa, A.; Kawashima, T.; Otani, K.; Aoki, S.; Kanno, J.; Isomura, S.; Sato, Y.; Takeda, K. Triphasic Continuous-Flow Oxidation System for Alcohols Utilizing Graft-Polymer-Supported TEMPO. Asian J. Org. Chem., 2018, 7, 1071-1074.    

2.Isomura, S.; Horigome, A.; Kubo, K.; Yoshizawa, Y.; Okuno, Y.; Okayasu, M.; Azumaya I.; Sato, Y. Green Synthesis of 1,4-Dihydropyridine Derivative in Water. Chemistry Select, 2018, 3, 3003-3005.      

3.Wakiyama, Y.; Kumura, K.; Umemura, E.; Masaki, S.; Ueda, K.; Sato, Y.; Hirai, Y.; Hayashi, Y.; Ajito, K. Synthesis and SARs of novel lincomycin derivatives Part 5. Optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions. Journal of Antibiotics, 2018, 71, 298-317.    

4.Wakiyama, Y.; Kumura, K.; Umemura, E.; Masaki, S.; Ueda, K.; Sato, Y.; Watanabe, T.; Hirai, Y.; Ajito, K. Synthesis and Structure–activity Relationships of Novel Lincomycin Derivatives Part 3: Discovery of the 4-(pyrimidin-5-yl)phenyl Group in Synthesis of 7(S)-thiolincomycin Analogs. Journal of Antibiotics, 2017, 70, 52-64.       

5.Hayashi, D.; Kato, N.; Kuzuyama, T.; Sato, Y.; Ohkanda, J.; Antimicrobial N-(2-chlorobenzyl)-substituted Hydroxamate is an Inhibitor of 1-Deoxy-D-xylulose 5-Phospate Synthase. Chem. Comn. 2013, 49, 5535-5537.

6.Horita, Y.; Takii, T; Yagi, T.; Ogawa, K.; Fujiwara, N.; Inagaki, E.;  Kremer, L.; Sato, Y.; Kuroishi, R.; Lee, Y.; Makino, T.; Mizukami, H.; Hasegawa, T.; Yamamoto, R.; Onozaki, K. Antitubecular Activity of Disulfiram, an Antialcoholism Drug, against Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates. Antimicrob. Agents Chemother. 2012, 56, 4140-4145.

7.Horita, Y.; Takii, T.; Kuroishi, R.; Chiba, T.; Ogawa, K.; Kremer, L.; Sato, Y.; Lee, Y.; Hasegawa, T.; Onozaki, K. Synthesis and Evaluation of Anti-tubercular Activity of new Dithiocarbamate Sugar Derivatives. Bioorg. Med. Chem. Lett. 2011, 21, 899-903.

8.Ishikawa, M.; Watanabe, T.; Kudo, T; Yokoyama, F.; Yamauchi, M.; Kato, K; Kakui, N.; Sato, Y. Investigation of the Histamine H3 Receptor Binding Site. Design and Synthesis of Hybrid Agonists with a Lipophilic Side Chain. J. Med. Chem. 2010, 53, 6445-6456.

9.Ishikawa, M.; Furuuchi, T.; Yamauchi, M.; Yokoyama, F.; Kakui, N.; Sato, Y. Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor. Bioorg. Med. Chem. 2010, 18, 5441–5448.

10.Ishikawa, M.; Shinei, R.; Yokoyama, F.; Yamauchi, M.; Oyama, M.; Okuma, K.; Nagayama, T.; Kato, K.; Kakui, N.; Sato, Y. Role of Hydrophobic Substituents on the Terminal Nitrogen of Histamine in Receptor Binding and Agonist Activity: Development of an Orally Active Histamine Type 3 Receptor Agonist and Evaluation of Its Antistress Activity in Mice. J. Med. Chem. 2010, 53, 3840-3844.

11.Yokoyama, F.; Yamauchi, M.; Oyama, M.; Okuma, K.; Onozawa, K.; Nagayama, T.; Shinei, R.; Ishikawa M.; Sato, Y.; Kakui, N. Anxiolytic-like Profiles of Histamine H3 Receptor Agonists in Animal Models of Anxiety: a Comparative Study with Antidepressants and Benzodiazepine Anxiolytic. Psychopharmacology 2009, 205(2), 177-187.

12.Yoshida, S.; Watanabe, T.; Sato, Y. Reguratory Molecules for the 5-HT3 Receptor Ion Channel Gating System. Bioorg. Med. Chem. 2007, 15, 3515-3523.

13.Yoshida, S.; Shiokawa, S.; Kawano, K.; Ito, T.; Murakami, H.; Suzuki, H.; Sato, Y. Orally Active Benzoxazole Derivative as 5-HT3 Receptor Partial Agonist for Treatment of Diarrhea-Predominant Irritable Bowel Syndrome. J. Med. Chem. 2005, 48, 7075-7079.

14.Kawano, K.; Mori, T.; Fu, I.; Ito, T.; Niisato, T.; Yoshida, S; Shiokawa, S.; Sato, Y; Murakami, H.; Shishikura, T. Comparison between Partial Agonist (ME3412) and Antagonist (alosetron) of 5-Hydroxytryptamine 3 receptor on Gastrointestinal Function. Neurogastroenterol. & Motil. 2005, 17(2), 290-301.

15.Tsushima, M.; Iwamatsu, K.; Umemura, E.; Kudo, T.; Sato, Y.; Siokawa, S.; Takizawa, H.; Kano, Y; Kobayashi, K.; Ida, T.; Tamura, A.; Atsumi, K. CP6679, a New Injectable Cephalosporin: I. Synthesis and Structure-Activity Relationships. Bioorg. Med. Chem. 2000, 8, 2781-2789.

16.Sato, Y.; Yamada, M.; Yoshida, S.; Soneda, T.; Ishikawa, M.; Nizato, T.; Suzuki, K.; Konno, F. Benzoxazole Derivatives as Novel 5-HT3 Receptor Partial Agonists in the Gut. J. Med. Chem. 1998, 41, 3015-3021.

著書及び総説

メディシナルケミストリー用語解説260(共同執筆、日本薬学会編),じほう,2007

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