教員紹介

鰐渕 清史
Wanibuchi Kiyofumi

所属・肩書

薬科学科/天然物有機化学研究室、創薬研究センター(准教授)

最終学歴

静岡県立大学大学院薬学研究科 博士後期課程修了

取得学位

博士(薬学)(静岡県立大学)

所属学会

日本薬学会、日本生薬学会、日本農芸化学会

現在の専門分野

天然物化学、有機合成化学

現在の研究課題

●抗菌活性を有する化合物の研究
●ヘテロ環化合物の効率的合成法の開発

主要研究業績

植物由来ポリケタイド合成酵素の構造機能解析

最近の研究業績

1.Kiyofumi Wanibuchi, Hiroyuki Morita, Hiroshi Noguchi, Ikuro Abe, " Enzymatic Formation of An Aromatic Dodecaketide by Engineered Plant Polyketide Synthase ". Bioorg. Med. Chem. Lett, 21, 2083 - 2086 (2011).

2.Hiroyuki Morita, Takahiro Mori, Kiyofumi Wanibuchi, Ryohei Kato, Shigetoshi Sugio, Ikuro Abe, " Crystallization and preliminary X-ray analysis of 4-coumarate:CoA ligase from Arabidopsis thaliana ". Acta Crystallogr, F67, 409 -411 (2011).

3.Hiroyuki Morita, Kiyofumi Wanibuchi, Hirohiko Nii, Ryohei Kato, Shigetoshi Sugio, Ikuro Abe, " Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa ". Proc. Natl. Acad. Sci. USA, 107, 19778 -19783 (2010).

4.Hiroyuki Morita, Kiyofumi Wanibuchi, Ryohei Kato, Shigetoshi Sugio, Ikuro Abe, " Expression, purification and crystallization of a plant type III polyketide synthase that produces diarylheptanoids ". Acta Crystallogr, F66, 948 – 950 (2010).

5.Yuusuke Mizuuchi, She-Po Shi, Kiyofumi Wanibuchi, Akiko Kojima, Hiroyuki Morita, Hiroshi Noguchi, Ikuro Abe, "Novel Type III Polyketide Synthases from Aloe arborescens". FEBS J, 276, 2391 – 2401 (2009).

6.She-Po Shi, Hiroyuki Morita, Kiyofumi Wanibuchi, Hiroshi Noguchi, Ikuro Abe, "Enzymatic Formation of Unnatural Novel Polyketide Scaffolds by Plant Type III Polyketide Synthase". Tetr. Lettr. 50, 2150 – 2153 (2009)

7.She-Po Shi, Kiyofumi Wanibuchi, Hiroyuki Morita, Kohei Endo, Hiroshi Noguchi, Ikuro Abe, "Enzymatic Formation of Unnatural Novel Chalcone, Stilbene, and Benzophenone Scaffolds by Type III Polyketide Synthase". Organic Lettr, 11, 551 – 554 (2009).

8.Yuusuke Mizuuchi, Yoshihiko Shimokawa, Kiyofumi Wanibuchi, Hiroshi Noguchi, Ikuro Abe, "Structure Function Analysis of Novel Type III Polyketide Synthases from Arabidopsis thaliana". Biol. Pharm. Bull, 31, 2205- 2210 (2008).

9.Hiroyuki Morita, Michikazu Tanio, Shin Kondo, Ryohei Kato, Kiyofumi Wanibuchi, Hiroshi Noguchi, Shigetoshi Sugio, Ikuro Abe, Toshiyuki Kohno, " Crystallization and preliminary crystallographic analysis of a plant type III polyketide synthase that produces benzalacetone ". Acta Crystallogr, F64, 304 – 306 (2008).

10.Hiroyuki Morita, Shin Kondo, Ryohei Kato, Kiyofumi Wanibuchi, Hiroshi Noguchi, Shigetoshi Sugio, Ikuro Abe, " Crystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata ". Acta Crystallogr, F63, 576-578 (2007).

11.Hiroyuki Morita, Shin Kondo, Ryohei Kato, Kiyofumi Wanibuchi, Hiroshi Noguchi, Shigetoshi Sugio, Ikuro Abe, Toshiyuki Kohno, "Crystallization and preliminary crystallographic analysis of an octaketide-producing plant type III polyketide synthase ". Acta Crystallogr, F63, 947 - 949 (2007).

12.Ikuro Abe, Hiroyuki Morita, Satoshi Oguro, Hisashi Noma, Kiyofumi Wanibuchi, Nobuo Kawahara, Yukihiro Goda, Hiroshi Noguchi, Toshiyuki Kohno, "Structure-based Engineering of a Plant Type III Polyketide Synthase: Formation of an Unnatural Nonaketide Naphthopyrone".
 J. Am. Chem. Soc, 129, 5976- 5980 (2007).

13.Kiyofumi Wanibuchi, Ping Zhang, Tsuyoshi Abe, Hiroyuki Morita, Toshiyuki Kohno, Guoshin Chen, Hiroshi Noguchi, Ikuro Abe, "An Acridone-Producing Novel Type III Polyketide Synthase from Huperzia serrata". FEBS J, 274, 1073 - 1082(2007).

14.Ikuro Abe, Tsuyoshi Abe, Kiyofumi Wanibuchi, Hiroshi Noguchi, "Enzymatic Formation of Quinolone Alkaloidss by A Plant Type III Polyketide Synthase". Organic Lettr, 8, 6063-6065 (2006).

受賞

日本薬学会生薬天然物部会奨励研究賞 (2011年)

著書及び総説

鰐渕清史 , “大腸菌が生み出すクルクミン” ファルマシアートピックス 生薬・天然物化学 (2009年8月)

入試情報 ADMISSION