教員プロフィール

岡 美佳子

岡 美佳子

Oka Mikako

薬科学科/臨床解析学研究室、臨床薬学科/臨床薬理学研究室(教授)

最終学歴

東京工業大学大学院総合理工学研究科博士後期課程 修了

取得学位

理学博士

所属学会

日本白内障学会、日本眼科学会、日本眼薬理学会、日本薬学会日本細胞生物学会、
日本発生生物学会、日本生化学会、日本動物学会、日本バイオイメージング学会

現在の専門分野

細胞生物学、生化学、分子生物学

現在の研究課題
  • 抗白内障薬の検索
  • 水晶体透明性維持機構の解明
  • 幹細胞を用いた水晶体再生の試み
主要研究業績
  • 鞭毛軸糸の運動制御機構の研究
  • 分裂装置内の微小管の異種混交性の研究
  • 水晶体内の細胞骨格の研究
  • 水晶体上皮細胞に存在する幹細胞の研究
受賞
  • 日本白内障学会第22回学術賞 受賞
最近の研究業績
  1. Oka M, Takehana M, Nakazawa Y, Ushikubo H, Satoh K. (2019) Stability of 2-amino-3-hydroxyacetophenone-O-β-D-glucoside against near-UV irradiation. J Japan Soc Cat Res 31:58-62.
  2. Nakazawa Y, Oka M, Tamura H, Takehana M. (2017) Model for Studying Anti-allergic Drugs for Allergic Conjunctivitis animals. Open Medicine 12;231-238.
  3. Nagai N, Ueno A, Tanino T, Oka M, Ito Y. (2017) Co-administration of magnesium ion Prevents indomethacin-induced intestinal ulcerogenic lesions in adjuvant-induced arthritis rats. Biol Pharm Bull.40(6):910-915.
  4. 岡美佳子、長井紀章. (2017) 白内障への薬学的アプローチ 日本白内障学会誌29 48-49.
  5. Oka M, Nakazawa Y, Hada N, Kiuchi F, Matsushima Y, Chiba K, Takehana, M. (2016)Evaluation of the inhibitory effects of Rokumigan and Hachimijiogan on cataract formation in a rat model of streptozotocin-induced type-1 diabetes. J Jpn Soc Cat Res 28:97-105 (2016).
  6. Nakazawa Y, Oka M, Tamura H, Takehana M.(2016) Effect of hesperetin of chaperone activity in selenite-induced cataract. Open Med 11: 183-189 (2016).
  7. Nakazawa Y, Oka M, Bando M, Inoue T, Takehana M.(2015) Hesperetin prevents selenite-induced cataract in rats. Mol Vis, 21: 804–810 (2015).
  8. Oka M, Umezawa K, Nakajima Y, Nakazawa Y, Takehana M. Life span of mRNA in lens. (2015) J Jpn Soc Cat Res 27:50-62.
  9. Nakazawa Y, Oka M, Furuki K, Mitsuishi A, Nakashim E, Takehana M. (2011) The effect of the interaction between aquaporin 0 (AQP0) and the filensin tail region on AQP0 water permeability. Mol Vis 17:3191-3199.
  10. Nakazawa Y, Oka M, Mitsuishi A, Bando M, Takehana M. (2011)Quantitative analysis of ascorbic acid permeability of aquaporin 0 in the lens. Biochemical and Biophysical Research Communications 415:125-130.
  11. The role of ascorbic acid transporter in the lens of streptozotocin-induced diabetic rat. Biomedicine & Preventive Nutrition 1:43-48.
  12. 井上順、岡美佳子、井上恵理、徳田直人、竹鼻眞、上野聰樹. (2011) プロスタグラン人関連薬のウサギ角膜上皮細胞に対する影響. 新しい眼科28: 886-890.
  13. 岡美佳子. (2011) 水晶体中の細胞骨格. 日本白内障学会誌 23: 19-24.
  14. Bando M, Oka M, Nakazawa Y, Kawai K, Obazawa H, Takehana M (2010) Suppression of Redox Activities of Rabbit Lens Lambda-Crystallin by Glutathionylation. J Jpn Soc Cat Res 22:43-49.
  15. Oka M, Toyoda C, Kaneko Y, Nakazawa Y, Aizu-Yokota E, Takehana M. (2010) Characterization and localization of side population cells in the lens. Mol Vis 16:945-953.
  16. Nakazawa Y, Takehana M, Oka M, FShibuya F, Katakawa J, Sano Y. (2009) UV-B irradiation-induced electron transfer between 3-hydroxykynurenine and tryptophan.Journal of Biological Macromolecules 9:13-22.
  17. Bando M, Inoue T, Oka M, Kawai K, Obazawa H, Takehana M. (2008) Amino Acid Sequence and Western Blot Analyses of Ascorbate Free Radical Reductase Purified from Rabbit Lens Soluble Fraction. J Jpn Soc Cat Res 21:50-55.
  18. Sawano M, Imai T, Oka M, Yamamoto N, Nakajima Y, Hisanaga S, Matsushima H, Senoo T, Takehana M. (2008) Function and Localization of Microtubules in the Lens. J Jpn Soc Cat Res 20:52-57.
  19. Oka M, Kudo H, Sugama N, Asami Y, Takehana M. (2008) The function of filensin and phakinin in lens transparency. Mol Vis 14: 815-822.
  20. Inoue T, Oka M, Bando M, Obazawa H Takehana M. (2007) Characterization of Ascorbate Free Radical Reductase in Rabbit Lens. J Jpn Soc Cat Res 19: 35-40.
  21. Bando M, Oka M, Kawai K, Obazawa H, Takehana M. (2007) NADH photo-oxidation is enhanced by a partially purified lambda-crystallin fraction from rabbit lens. Mol Vis 13:1722-1729.
  22. Bando M, Oka M, Kawai K, Obazawa H, Kobayashi S, Takehana M. (2006) NADH binding properties of rabbit lens λ-crystallin. Mol Vis 12: 692-697.
  23. Oka M, Sugama N, Shoji E, Kobayashi S, Takehana M. (2006) Ability of the free radical scavenger MCI-186 to protect the lens from ultraviolet radiation-induced damage. The Journal of Kyoritu University of Pharmacy 1: 85-90.
  24. Nakamura K, Oka M, Takehana M, Kobayashi S, Tamura H. (2005) Changes in the gene expression of drug metabolizing enzymes during cataractogenesis in Shumiya cataract rats. J Health Sci 51: 734-737.
  25. Bando M, Inoue T, Oka M, Nakamura K, Kawai K, Obazawa H, Kobayashi S, Takehana M. (2004) Isolation of ascorbate free radical reductase from rabbit lens soluble fraction. Experimental Eye Research 79: 869-873.
  26. Oka M, Shimizu K, Nakamura K, Kobayashi S, Takehana M. (2004) Lentoid Body Formation and Expression of Major Intrinsic Polypeptide (MIP) 26 on a PTFE Membrane. J Jpn Soc Cat Res 16: 63-68.
  27. Inoue J, Oka M, Aoyama Y, Kobayashi S, Ueno S, Hada N, Takeda T, Takehana M. (2004) Effects of Dorzolamide Hydrochloride on Ocular Tissues. J Ocul Pharmacol Ther 20: 1-13.
  28. Suzuki T, Bando M, Oka M, Tsukamoto H, Akatsuka I, Kawai K, Obazawa H, Kobayashi S, Takehana M. (2003) Lambda-Crystallin related to dehydroascorbate reductase in the rabbit lens. Jpn J Ophthalmol 47: 437-443.
  29. Matsubara Y, Oka M, Shumiya S, Nakamura K, Kobayashi S, Takehana M. (2003) Changes of MIP26K linked with cataract formation and maturation in the lenses of the Shumiya Cataract Rat. J Jpn Soc Cat Res 15: 47-49.
  30. Akatsuka I, Bando M, Obazawa H, Oka M, Takehana M, Kobayashi S. (2001) NADH-dependent Dehydroascorbate Reductase in the Rabbit Lens. Tokai J Exp Clin Med 26: 25-32.
  31. Kiriyama MT, Oka M, Takehana M, Kobayashi S (2001) Expression of a small heat shock protein 27 (HSP27) in mouse skin tumors induced by UVB-irradiation. Biol Pharm Bull 24: 197-200.
  32. 井上順、岡美佳子、青山裕美子、徳田直人、小林静子、上野聰樹、竹鼻眞.  (2000) 抗緑内障点眼薬のウサギ角膜上皮細胞に対する影響. 聖マリアンナ医科大学雑誌 31:195-206.
  33. 松倉修司、板東正康、尾羽澤大、岡美佳子、竹鼻眞. (2000) 各種動物水晶体のアスコルビン酸フリーラジカル還元酵素活性. 日本眼科学会雑誌104:384-389.
著書
  1. 岡美佳子. (2013)
    「新細胞生物学」(竹鼻 眞, 高橋 悟, 野尻 久雄 編)
    執筆担当部分:8章 個体の発生・細胞の分化・老化・死とは、9章 遺伝.
    廣川書店 (東京) 215-250.
  2. Oka MT, Hamaguchi Y. (1991)
    “Biology of Echinodermata” Yasumasu Y,eds, et al
    執筆担当部分:Heterogeneity of microtubules in dividing sea urchin eggs.
    CRC Press (Rotterdam) 385-389.
  3. 岡美佳子、浜口幸久.(1997)
    「バイオマニュアルUPシリーズ 細胞骨格・細胞運動へのアプローチ」(馬淵一誠編)
    執筆担当部分:抗体のマイクロインジェクション.
    羊土社(東京) 197-200.